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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance.
Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H. Xu H, et al. Among authors: chou cj. J Clin Invest. 2003 Dec;112(12):1821-30. doi: 10.1172/JCI19451. J Clin Invest. 2003. PMID: 14679177 Free PMC article.
Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity.
Hubbard B, Doege H, Punreddy S, Wu H, Huang X, Kaushik VK, Mozell RL, Byrnes JJ, Stricker-Krongrad A, Chou CJ, Tartaglia LA, Lodish HF, Stahl A, Gimeno RE. Hubbard B, et al. Among authors: chou cj. Gastroenterology. 2006 Apr;130(4):1259-69. doi: 10.1053/j.gastro.2006.02.012. Gastroenterology. 2006. PMID: 16618417
Germ-free C57BL/6J mice are resistant to high-fat-diet-induced insulin resistance and have altered cholesterol metabolism.
Rabot S, Membrez M, Bruneau A, GĂ©rard P, Harach T, Moser M, Raymond F, Mansourian R, Chou CJ. Rabot S, et al. Among authors: chou cj. FASEB J. 2010 Dec;24(12):4948-59. doi: 10.1096/fj.10-164921. Epub 2010 Aug 19. FASEB J. 2010. PMID: 20724524
Development of a Bestatin-SAHA Hybrid with Dual Inhibitory Activity against APN and HDAC.
Cao J, Zhao W, Zhao C, Liu Q, Li S, Zhang G, Chou CJ, Zhang Y. Cao J, et al. Among authors: chou cj. Molecules. 2020 Oct 28;25(21):4991. doi: 10.3390/molecules25214991. Molecules. 2020. PMID: 33126591 Free PMC article.
Design, synthesis and biological evaluation of dual-function inhibitors targeting NMDAR and HDAC for Alzheimer's disease.
He F, Ran Y, Li X, Wang D, Zhang Q, Lv J, Yu C, Qu Y, Zhang X, Xu A, Wei C, Chou CJ, Wu J. He F, et al. Among authors: chou cj. Bioorg Chem. 2020 Oct;103:104109. doi: 10.1016/j.bioorg.2020.104109. Epub 2020 Jul 21. Bioorg Chem. 2020. PMID: 32768741
Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent.
Xu Q, Liu C, Zang J, Gao S, Chou CJ, Zhang Y. Xu Q, et al. Among authors: chou cj. Front Cell Dev Biol. 2020 Jul 14;8:454. doi: 10.3389/fcell.2020.00454. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32760715 Free PMC article.
Discovery of the First Vitamin K Analogue as a Potential Treatment of Pharmacoresistant Seizures.
Li X, Himes RA, Prosser LC, Christie CF, Watt E, Edwards SF, Metcalf CS, West PJ, Wilcox KS, Chan SSL, Chou CJ. Li X, et al. Among authors: chou cj. J Med Chem. 2020 Jun 11;63(11):5865-5878. doi: 10.1021/acs.jmedchem.0c00168. Epub 2020 May 22. J Med Chem. 2020. PMID: 32390424
Design of Hydrazide-Bearing HDACIs Based on Panobinostat and Their p53 and FLT3-ITD Dependency in Antileukemia Activity.
Li X, Jiang Y, Peterson YK, Xu T, Himes RA, Luo X, Yin G, Inks ES, Dolloff N, Halene S, Chan SSL, Chou CJ. Li X, et al. Among authors: chou cj. J Med Chem. 2020 May 28;63(10):5501-5525. doi: 10.1021/acs.jmedchem.0c00442. Epub 2020 May 6. J Med Chem. 2020. PMID: 32321249
Gel-like ionic complexes for antimicrobial, hemostatic and adhesive properties.
Jhiang JS, Wu TH, Chou CJ, Chang Y, Huang CJ. Jhiang JS, et al. Among authors: chou cj. J Mater Chem B. 2019 May 7;7(17):2878-2887. doi: 10.1039/c8tb03367f. Epub 2019 Apr 5. J Mater Chem B. 2019. PMID: 32255090
The update of chimeric antigen receptor-T cells therapy in glioblastoma.
Chou CJ, Lin CF, Chen YW, Huang PI, Yang YP, Wang ML, Hung KF, Lee YY. Chou CJ, et al. J Chin Med Assoc. 2020 May;83(5):442-445. doi: 10.1097/JCMA.0000000000000302. J Chin Med Assoc. 2020. PMID: 32217989
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