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1Alpha,25-dihydroxyvitamin D3 up-regulates P-glycoprotein via the vitamin D receptor and not farnesoid X receptor in both fxr(-/-) and fxr(+/+) mice and increased renal and brain efflux of digoxin in mice in vivo.
Chow EC, Durk MR, Cummins CL, Pang KS. Chow EC, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):846-59. doi: 10.1124/jpet.111.179101. Epub 2011 Mar 18. J Pharmacol Exp Ther. 2011. PMID: 21421739
Why we need proper PBPK models to examine intestine and liver oral drug absorption.
Chow EC, Pang KS. Chow EC, et al. Curr Drug Metab. 2013 Jan;14(1):57-79. Curr Drug Metab. 2013. PMID: 22935069 Review.
Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.
Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS. Quach HP, et al. Among authors: chow ecy. Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30. Biopharm Drug Dispos. 2018. PMID: 29243851
Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.
Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS. Chow EC, et al. J Pharm Sci. 2011 Apr;100(4):1594-604. doi: 10.1002/jps.22366. Epub 2010 Oct 21. J Pharm Sci. 2011. PMID: 20967888
The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.
Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM. Khan AA, et al. Among authors: chow ec. Toxicol In Vitro. 2011 Feb;25(1):80-90. doi: 10.1016/j.tiv.2010.09.011. Epub 2010 Oct 1. Toxicol In Vitro. 2011. PMID: 20888898
1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.
Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. Chow EC, et al. Biopharm Drug Dispos. 2009 Nov;30(8):457-75. doi: 10.1002/bdd.682. Biopharm Drug Dispos. 2009. PMID: 19753549
Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers.
Chow EC, Liu L, Ship N, Kluger RH, Pang KS. Chow EC, et al. Drug Metab Dispos. 2008 May;36(5):937-45. doi: 10.1124/dmd.107.019174. Epub 2008 Feb 14. Drug Metab Dispos. 2008. PMID: 18276837
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.
Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS. Durk MR, et al. Among authors: chow ec. J Neurosci. 2014 May 21;34(21):7091-101. doi: 10.1523/JNEUROSCI.2711-13.2014. J Neurosci. 2014. PMID: 24849345 Free PMC article.
Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.
Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ. Kim YC, et al. Among authors: chow ecy. J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29. J Pharm Sci. 2014. PMID: 25266751
Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling.
Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS. Yang QJ, et al. Among authors: chow ecy. Drug Metab Dispos. 2018 Jan;46(1):75-87. doi: 10.1124/dmd.117.077271. Epub 2017 Oct 30. Drug Metab Dispos. 2018. PMID: 29084783
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