Chow EC - Search Results

1

Why we need proper PBPK models to examine intestine and liver oral drug absorption.

Chow EC, Pang KS. Chow EC, et al. Curr Drug Metab. 2013 Jan;14(1):57-79. Curr Drug Metab. 2013. PMID: 22935069 Review.

2

Commentary: theoretical predictions of flow effects on intestinal and systemic availability in physiologically based pharmacokinetic intestine models: the traditional model, segregated flow model, and QGut model.

Pang KS, Chow EC. Pang KS, et al. Among authors: chow ec. Drug Metab Dispos. 2012 Oct;40(10):1869-77. doi: 10.1124/dmd.112.045872. Epub 2012 Jun 27. Drug Metab Dispos. 2012. PMID: 22745334

3

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS. Quach HP, et al. Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30. Biopharm Drug Dispos. 2018. PMID: 29243851

4

1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.

Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS. Chow EC, et al. Biopharm Drug Dispos. 2009 Nov;30(8):457-75. doi: 10.1002/bdd.682. Biopharm Drug Dispos. 2009. PMID: 19753549

5

Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers.

Chow EC, Liu L, Ship N, Kluger RH, Pang KS. Chow EC, et al. Drug Metab Dispos. 2008 May;36(5):937-45. doi: 10.1124/dmd.107.019174. Epub 2008 Feb 14. Drug Metab Dispos. 2008. PMID: 18276837

6

Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ. Kim YC, et al. J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29. J Pharm Sci. 2014. PMID: 25266751

7

Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D₃ in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling.

Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS. Yang QJ, et al. Drug Metab Dispos. 2018 Jan;46(1):75-87. doi: 10.1124/dmd.117.077271. Epub 2017 Oct 30. Drug Metab Dispos. 2018. PMID: 29084783

8

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS. Chow EC, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):174-191. doi: 10.1124/jpet.116.236935. Epub 2016 Oct 27. J Pharmacol Exp Ther. 2017. PMID: 27789682

9

Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS. Chow EC, et al. Drug Metab Dispos. 2016 Sep;44(9):1524-35. doi: 10.1124/dmd.116.070060. Epub 2016 Jun 24. Drug Metab Dispos. 2016. PMID: 27342868

10

Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.

Ramakrishnan V, Yang QJ, Quach HP, Cao Y, Chow EC, Mager DE, Pang KS. Ramakrishnan V, et al. Among authors: chow ec. Drug Metab Dispos. 2016 Feb;44(2):189-208. doi: 10.1124/dmd.115.067033. Epub 2015 Nov 19. Drug Metab Dispos. 2016. PMID: 26586377

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