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A novel class of endotoxin receptor agonists with simplified structure, toll-like receptor 4-dependent immunostimulatory action, and adjuvant activity.
Hawkins LD, Ishizaka ST, McGuinness P, Zhang H, Gavin W, DeCosta B, Meng Z, Yang H, Mullarkey M, Young DW, Yang H, Rossignol DP, Nault A, Rose J, Przetak M, Chow JC, Gusovsky F. Hawkins LD, et al. Among authors: chow jc. J Pharmacol Exp Ther. 2002 Feb;300(2):655-61. doi: 10.1124/jpet.300.2.655. J Pharmacol Exp Ther. 2002. PMID: 11805229 Clinical Trial.
Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo.
Lamphier M, Zheng W, Latz E, Spyvee M, Hansen H, Rose J, Genest M, Yang H, Shaffer C, Zhao Y, Shen Y, Liu C, Liu D, Mempel TR, Rowbottom C, Chow J, Twine NC, Yu M, Gusovsky F, Ishizaka ST. Lamphier M, et al. Among authors: chow j. Mol Pharmacol. 2014 Mar;85(3):429-40. doi: 10.1124/mol.113.089821. Epub 2013 Dec 16. Mol Pharmacol. 2014. PMID: 24342772
The extra domain A of fibronectin activates Toll-like receptor 4.
Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, Rose J, Chow JC, Strauss JF 3rd. Okamura Y, et al. Among authors: chow jc. J Biol Chem. 2001 Mar 30;276(13):10229-33. doi: 10.1074/jbc.M100099200. Epub 2001 Jan 9. J Biol Chem. 2001. PMID: 11150311 Free article.
Respiratory syncytial virus fusion protein-induced toll-like receptor 4 (TLR4) signaling is inhibited by the TLR4 antagonists Rhodobacter sphaeroides lipopolysaccharide and eritoran (E5564) and requires direct interaction with MD-2.
Rallabhandi P, Phillips RL, Boukhvalova MS, Pletneva LM, Shirey KA, Gioannini TL, Weiss JP, Chow JC, Hawkins LD, Vogel SN, Blanco JC. Rallabhandi P, et al. mBio. 2012 Aug 7;3(4):e00218-12. doi: 10.1128/mBio.00218-12. Print 2012. mBio. 2012. PMID: 22872782 Free PMC article.
2,096 results