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Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells.
Zhong Z, Ilieva H, Hallagan L, Bell R, Singh I, Paquette N, Thiyagarajan M, Deane R, Fernandez JA, Lane S, Zlokovic AB, Liu T, Griffin JH, Chow N, Castellino FJ, Stojanovic K, Cleveland DW, Zlokovic BV. Zhong Z, et al. Among authors: chow n. J Clin Invest. 2009 Nov;119(11):3437-49. doi: 10.1172/JCI38476. Epub 2009 Oct 19. J Clin Invest. 2009. PMID: 19841542 Free PMC article.
355 results