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DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells.
He YJ, Meghani K, Caron MC, Yang C, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drané P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D. He YJ, et al. Among authors: chowdhury d, d andrea ad. Nature. 2018 Nov;563(7732):522-526. doi: 10.1038/s41586-018-0670-5. Epub 2018 Oct 31. Nature. 2018. PMID: 30464262 Free PMC article.
A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. Keogh MC, et al. Among authors: chowdhury d. Nature. 2006 Jan 26;439(7075):497-501. doi: 10.1038/nature04384. Epub 2005 Nov 20. Nature. 2006. PMID: 16299494
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
Moskwa P, Buffa FM, Pan Y, Panchakshari R, Gottipati P, Muschel RJ, Beech J, Kulshrestha R, Abdelmohsen K, Weinstock DM, Gorospe M, Harris AL, Helleday T, Chowdhury D. Moskwa P, et al. Among authors: chowdhury d. Mol Cell. 2011 Jan 21;41(2):210-20. doi: 10.1016/j.molcel.2010.12.005. Epub 2010 Dec 30. Mol Cell. 2011. PMID: 21195000 Free PMC article.
DNA breaks and chromosome pulverization from errors in mitosis.
Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, Pellman D. Crasta K, et al. Among authors: chowdhury d. Nature. 2012 Jan 18;482(7383):53-8. doi: 10.1038/nature10802. Nature. 2012. PMID: 22258507 Free PMC article.
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
Johnson N, Johnson SF, Yao W, Li YC, Choi YE, Bernhardy AJ, Wang Y, Capelletti M, Sarosiek KA, Moreau LA, Chowdhury D, Wickramanayake A, Harrell MI, Liu JF, D'Andrea AD, Miron A, Swisher EM, Shapiro GI. Johnson N, et al. Among authors: chowdhury d, d andrea ad. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17041-6. doi: 10.1073/pnas.1305170110. Epub 2013 Oct 1. Proc Natl Acad Sci U S A. 2013. PMID: 24085845 Free PMC article.
Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks.
Lee DH, Acharya SS, Kwon M, Drane P, Guan Y, Adelmant G, Kalev P, Shah J, Pellman D, Marto JA, Chowdhury D. Lee DH, et al. Among authors: chowdhury d. Mol Cell. 2014 May 8;54(3):512-25. doi: 10.1016/j.molcel.2014.03.020. Epub 2014 Apr 3. Mol Cell. 2014. PMID: 24703952 Free PMC article.
Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian Cancer.
Choi YE, Meghani K, Brault ME, Leclerc L, He YJ, Day TA, Elias KM, Drapkin R, Weinstock DM, Dao F, Shih KK, Matulonis U, Levine DA, Konstantinopoulos PA, Chowdhury D. Choi YE, et al. Among authors: chowdhury d. Cell Rep. 2016 Jan 26;14(3):429-439. doi: 10.1016/j.celrep.2015.12.046. Epub 2016 Jan 7. Cell Rep. 2016. PMID: 26774475 Free PMC article.
653 results