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A non-immunogenic adenoviral vector, coexpressing CTLA4Ig and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome.
Thummala NR, Ghosh SS, Lee SW, Reddy B, Davidson A, Horwitz MS, Chowdhury JR, Chowdhury NR. Thummala NR, et al. Among authors: chowdhury jr, chowdhury nr. Gene Ther. 2002 Aug;9(15):981-90. doi: 10.1038/sj.gt.3301729. Gene Ther. 2002. PMID: 12101428
Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression.
Ilan Y, Droguett G, Chowdhury NR, Li Y, Sengupta K, Thummala NR, Davidson A, Chowdhury JR, Horwitz MS. Ilan Y, et al. Among authors: chowdhury jr, chowdhury nr. Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2587-92. doi: 10.1073/pnas.94.6.2587. Proc Natl Acad Sci U S A. 1997. PMID: 9122239 Free PMC article.
204 results