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A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.
Christensen NR, De Luca M, Lever MB, Richner M, Hansen AB, Noes-Holt G, Jensen KL, Rathje M, Jensen DB, Erlendsson S, Bartling CR, Ammendrup-Johnsen I, Pedersen SE, Schönauer M, Nissen KB, Midtgaard SR, Teilum K, Arleth L, Sørensen AT, Bach A, Strømgaard K, Meehan CF, Vaegter CB, Gether U, Madsen KL. Christensen NR, et al. EMBO Mol Med. 2020 Jun 8;12(6):e11248. doi: 10.15252/emmm.201911248. Epub 2020 Apr 30. EMBO Mol Med. 2020. PMID: 32352640 Free PMC article.
An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1.
Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, Weinstein H, Kjærulff O, Stamou D, Gether U, Madsen KL. Herlo R, et al. Among authors: christensen nr. Cell Rep. 2018 May 15;23(7):2056-2069. doi: 10.1016/j.celrep.2018.04.074. Cell Rep. 2018. PMID: 29768204 Free article.
Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis.
Andersen RC, Schmidt JH, Rombach J, Lycas MD, Christensen NR, Lund VK, Stapleton DS, Pedersen SS, Olsen MA, Stoklund M, Noes-Holt G, Nielsen TT, Keller MP, Jansen AM, Herlo R, Pietropaolo M, Simonsen JB, Kjærulff O, Holst B, Attie AD, Gether U, Madsen KL. Andersen RC, et al. Among authors: christensen nr. J Clin Invest. 2022 Mar 1;132(5):e144904. doi: 10.1172/JCI144904. J Clin Invest. 2022. PMID: 35077398 Free PMC article.
PDZ Domains as Drug Targets.
Christensen NR, Čalyševa J, Fernandes EFA, Lüchow S, Clemmensen LS, Haugaard-Kedström LM, Strømgaard K. Christensen NR, et al. Adv Ther (Weinh). 2019 Jul;2(7):1800143. doi: 10.1002/adtp.201800143. Epub 2019 Apr 24. Adv Ther (Weinh). 2019. PMID: 32313833 Free PMC article. Review.
15 results