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RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA.
Christensen SK, Gerdes K. Christensen SK, et al. Mol Microbiol. 2003 Jun;48(5):1389-400. doi: 10.1046/j.1365-2958.2003.03512.x. Mol Microbiol. 2003. PMID: 12787364
Prokaryotic toxin-antitoxin stress response loci.
Gerdes K, Christensen SK, Løbner-Olesen A. Gerdes K, et al. Among authors: christensen sk. Nat Rev Microbiol. 2005 May;3(5):371-82. doi: 10.1038/nrmicro1147. Nat Rev Microbiol. 2005. PMID: 15864262 Review.
Delayed-relaxed response explained by hyperactivation of RelE.
Christensen SK, Gerdes K. Christensen SK, et al. Mol Microbiol. 2004 Jul;53(2):587-97. doi: 10.1111/j.1365-2958.2004.04127.x. Mol Microbiol. 2004. PMID: 15228536
Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system.
Christensen SK, Maenhaut-Michel G, Mine N, Gottesman S, Gerdes K, Van Melderen L. Christensen SK, et al. Mol Microbiol. 2004 Mar;51(6):1705-17. doi: 10.1046/j.1365-2958.2003.03941.x. Mol Microbiol. 2004. PMID: 15009896
Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA.
Christensen SK, Pedersen K, Hansen FG, Gerdes K. Christensen SK, et al. J Mol Biol. 2003 Sep 26;332(4):809-19. doi: 10.1016/s0022-2836(03)00922-7. J Mol Biol. 2003. PMID: 12972253
Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins.
Pedersen K, Christensen SK, Gerdes K. Pedersen K, et al. Among authors: christensen sk. Mol Microbiol. 2002 Jul;45(2):501-10. doi: 10.1046/j.1365-2958.2002.03027.x. Mol Microbiol. 2002. PMID: 12123459
RelE, a global inhibitor of translation, is activated during nutritional stress.
Christensen SK, Mikkelsen M, Pedersen K, Gerdes K. Christensen SK, et al. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14328-33. doi: 10.1073/pnas.251327898. Epub 2001 Nov 20. Proc Natl Acad Sci U S A. 2001. PMID: 11717402 Free PMC article.
A unilateral foveal vitelliform lesion in a choroideremia carrier.
Torm MEW, Eckmann-Hansen C, Christensen SK, Larsen M. Torm MEW, et al. Among authors: christensen sk. Retin Cases Brief Rep. 2020 Sep 23. doi: 10.1097/ICB.0000000000001062. Online ahead of print. Retin Cases Brief Rep. 2020. PMID: 33003127
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia.
Aldana BI, Zhang Y, Jensen P, Chandrasekaran A, Christensen SK, Nielsen TT, Nielsen JE, Hyttel P, Larsen MR, Waagepetersen HS, Freude KK. Aldana BI, et al. Among authors: christensen sk. Mol Brain. 2020 Sep 14;13(1):125. doi: 10.1186/s13041-020-00658-6. Mol Brain. 2020. PMID: 32928252 Free PMC article.
Clearance of activity-evoked K+ transients and associated glia cell swelling occur independently of AQP4: A study with an isoform-selective AQP4 inhibitor.
Toft-Bertelsen TL, Larsen BR, Christensen SK, Khandelia H, Waagepetersen HS, MacAulay N. Toft-Bertelsen TL, et al. Among authors: christensen sk. Glia. 2020 Jun 7. doi: 10.1002/glia.23851. Online ahead of print. Glia. 2020. PMID: 32506554
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