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34 results

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Page 1
Glucose-sensitive insulin with attenuation of hypoglycaemia.
Hoeg-Jensen T, Kruse T, Brand CL, Sturis J, Fledelius C, Nielsen PK, Nishimura E, Madsen AR, Lykke L, Halskov KS, Koščová S, Kotek V, Davis AP, Tromans RA, Tomsett M, Peñuelas-Haro G, Leonard DJ, Orchard MG, Chapman A, Invernizzi G, Johansson E, Granata D, Hansen BF, Pedersen TA, Kildegaard J, Pedersen KM, Refsgaard HHF, Alifrangis L, Fels JJ, Neutzsky-Wulff AV, Sauerberg P, Slaaby R. Hoeg-Jensen T, et al. Among authors: fledelius c. Nature. 2024 Oct;634(8035):944-951. doi: 10.1038/s41586-024-08042-3. Epub 2024 Oct 16. Nature. 2024. PMID: 39415004 Free PMC article.
Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans.
Kjeldsen TB, Hubálek F, Hjørringgaard CU, Tagmose TM, Nishimura E, Stidsen CE, Porsgaard T, Fledelius C, Refsgaard HHF, Gram-Nielsen S, Naver H, Pridal L, Hoeg-Jensen T, Jeppesen CB, Manfè V, Ludvigsen S, Lautrup-Larsen I, Madsen P. Kjeldsen TB, et al. Among authors: fledelius c. J Med Chem. 2021 Jul 8;64(13):8942-8950. doi: 10.1021/acs.jmedchem.1c00257. Epub 2021 May 4. J Med Chem. 2021. PMID: 33944562 Free article.
Disrupted hypothalamic transcriptomics and proteomics in a mouse model of type 2 diabetes exposed to recurrent hypoglycaemia.
Castillo-Armengol J, Marzetta F, Rodriguez Sanchez-Archidona A, Fledelius C, Evans M, McNeilly A, McCrimmon RJ, Ibberson M, Thorens B. Castillo-Armengol J, et al. Among authors: fledelius c. Diabetologia. 2024 Feb;67(2):371-391. doi: 10.1007/s00125-023-06043-x. Epub 2023 Nov 28. Diabetologia. 2024. PMID: 38017352 Free PMC article.
Development of small-molecule inhibitors targeting adipose triglyceride lipase.
Mayer N, Schweiger M, Romauch M, Grabner GF, Eichmann TO, Fuchs E, Ivkovic J, Heier C, Mrak I, Lass A, Höfler G, Fledelius C, Zechner R, Zimmermann R, Breinbauer R. Mayer N, et al. Among authors: fledelius c. Nat Chem Biol. 2013 Dec;9(12):785-7. doi: 10.1038/nchembio.1359. Epub 2013 Oct 6. Nat Chem Biol. 2013. PMID: 24096302 Free PMC article.
An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor.
Bhushan B, Granata D, Kaas CS, Kasimova MA, Ren Q, Cramer CN, White MD, Hansen AMK, Fledelius C, Invernizzi G, Deibler K, Coleman OD, Zhao X, Qu X, Liu H, Zurmühl SS, Kodra JT, Kawamura A, Münzel M. Bhushan B, et al. Among authors: fledelius c. Chem Sci. 2022 Feb 24;13(11):3256-3262. doi: 10.1039/d1sc06844j. eCollection 2022 Mar 16. Chem Sci. 2022. PMID: 35414877 Free PMC article.
Insulin treatment improves liver histopathology and decreases expression of inflammatory and fibrogenic genes in a hyperglycemic, dyslipidemic hamster model of NAFLD.
Jensen VS, Fledelius C, Zachodnik C, Damgaard J, Nygaard H, Tornqvist KS, Kirk RK, Viuff BM, Wulff EM, Lykkesfeldt J, Hvid H. Jensen VS, et al. Among authors: fledelius c. J Transl Med. 2021 Feb 17;19(1):80. doi: 10.1186/s12967-021-02729-1. J Transl Med. 2021. PMID: 33596938 Free PMC article.
Variation in diagnostic NAFLD/NASH read-outs in paired liver samples from rodent models.
Jensen VS, Tveden-Nyborg P, Zacho-Rasmussen C, Quaade ML, Ipsen DH, Hvid H, Fledelius C, Wulff EM, Lykkesfeldt J. Jensen VS, et al. Among authors: fledelius c. J Pharmacol Toxicol Methods. 2020 Jan-Feb;101:106651. doi: 10.1016/j.vascn.2019.106651. Epub 2019 Nov 13. J Pharmacol Toxicol Methods. 2020. PMID: 31733366 Free article.
34 results