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CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.
Cummins CL, Jacobsen W, Christians U, Benet LZ. Cummins CL, et al. Among authors: christians u. J Pharmacol Exp Ther. 2004 Jan;308(1):143-55. doi: 10.1124/jpet.103.058065. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569063
Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.
Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Frassetto L, et al. Among authors: christians u. Transplantation. 2005 Jul 15;80(1):13-7. doi: 10.1097/01.tp.0000165111.09687.4e. Transplantation. 2005. PMID: 16003227
Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.
Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Frassetto L, et al. Among authors: christians u. Biopharm Drug Dispos. 2013 Nov;34(8):442-51. doi: 10.1002/bdd.1860. Epub 2013 Sep 12. Biopharm Drug Dispos. 2013. PMID: 24030928 Free PMC article. Clinical Trial.
This article is a U.S. Government work and is in the public domain in the USA....
This article is a U.S. Government work and is in the public domain in the USA....
The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.
Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. Mancinelli LM, et al. Among authors: christians u. Clin Pharmacol Ther. 2001 Jan;69(1):24-31. doi: 10.1067/mcp.2001.113183. Clin Pharmacol Ther. 2001. PMID: 11180035 Clinical Trial.
Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.
Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Jacobsen W, et al. Among authors: christians u. Drug Metab Dispos. 2000 Nov;28(11):1369-78. Drug Metab Dispos. 2000. PMID: 11038166
In vitro evaluation of the disposition of A novel cysteine protease inhibitor.
Jacobsen W, Christians U, Benet LZ. Jacobsen W, et al. Among authors: christians u. Drug Metab Dispos. 2000 Nov;28(11):1343-51. Drug Metab Dispos. 2000. PMID: 11038163
Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.
Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Serkova N, et al. Among authors: christians u. J Pharmacol Exp Ther. 2000 Jul;294(1):323-32. J Pharmacol Exp Ther. 2000. PMID: 10871329
Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.
Soldner A, Benet LZ, Mutschler E, Christians U. Soldner A, et al. Among authors: christians u. Br J Pharmacol. 2000 Mar;129(6):1235-43. doi: 10.1038/sj.bjp.0703150. Br J Pharmacol. 2000. PMID: 10725273 Free PMC article.
The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. Serkova N, et al. Among authors: christians u. Br J Pharmacol. 2000 Feb;129(3):485-92. doi: 10.1038/sj.bjp.0703079. Br J Pharmacol. 2000. PMID: 10711346 Free PMC article.
Grapefruit juice activates P-glycoprotein-mediated drug transport.
Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Soldner A, et al. Among authors: christians u. Pharm Res. 1999 Apr;16(4):478-85. doi: 10.1023/a:1011902625609. Pharm Res. 1999. PMID: 10227700
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