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Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.
Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Gottschalk S, et al. Among authors: christians u. Neurotoxicology. 2011 Jan;32(1):50-7. doi: 10.1016/j.neuro.2010.10.006. Epub 2010 Nov 12. Neurotoxicology. 2011. PMID: 21075140
Metabolic profiles in urine reflect nephrotoxicity of sirolimus and cyclosporine following rat kidney transplantation.
Schmitz V, Klawitter J, Bendrick-Peart J, Schoening W, Puhl G, Haschke M, Klawitter J, Consoer J, Rivard CJ, Chan L, Tran ZV, Leibfritz D, Christians U. Schmitz V, et al. Among authors: christians u. Nephron Exp Nephrol. 2009;111(4):e80-91. doi: 10.1159/000209208. Epub 2009 Mar 17. Nephron Exp Nephrol. 2009. PMID: 19293597
Urine metabolites reflect time-dependent effects of cyclosporine and sirolimus on rat kidney function.
Klawitter J, Bendrick-Peart J, Rudolph B, Beckey V, Klawitter J, Haschke M, Rivard C, Chan L, Leibfritz D, Christians U, Schmitz V. Klawitter J, et al. Among authors: christians u. Chem Res Toxicol. 2009 Jan;22(1):118-28. doi: 10.1021/tx800253x. Chem Res Toxicol. 2009. PMID: 19099400 Free PMC article.
The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.
Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. Serkova N, et al. Among authors: christians u. Br J Pharmacol. 2000 Feb;129(3):485-92. doi: 10.1038/sj.bjp.0703079. Br J Pharmacol. 2000. PMID: 10711346 Free PMC article.
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Serkova N, et al. Among authors: christians u. Br J Pharmacol. 2001 Jul;133(6):875-85. doi: 10.1038/sj.bjp.0704142. Br J Pharmacol. 2001. PMID: 11454661 Free PMC article.
Everolimus and sirolimus in transplantation-related but different.
Klawitter J, Nashan B, Christians U. Klawitter J, et al. Among authors: christians u. Expert Opin Drug Saf. 2015 Jul;14(7):1055-70. doi: 10.1517/14740338.2015.1040388. Epub 2015 Apr 26. Expert Opin Drug Saf. 2015. PMID: 25912929 Free PMC article. Review.
Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.
Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA. Emoto C, et al. Among authors: christians u. Ther Drug Monit. 2015 Jun;37(3):395-9. doi: 10.1097/FTD.0000000000000130. Ther Drug Monit. 2015. PMID: 25162215 Clinical Trial.
Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.
Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Boernsen KO, et al. Among authors: christians u. J Mass Spectrom. 2007 Jun;42(6):793-802. doi: 10.1002/jms.1215. J Mass Spectrom. 2007. PMID: 17511017
Everolimus and sirolimus in combination with cyclosporine have different effects on renal metabolism in the rat.
Bohra R, Schöning W, Klawitter J, Brunner N, Schmitz V, Shokati T, Lawrence R, Arbelaez MF, Schniedewind B, Christians U, Klawitter J. Bohra R, et al. Among authors: christians u. PLoS One. 2012;7(10):e48063. doi: 10.1371/journal.pone.0048063. Epub 2012 Oct 31. PLoS One. 2012. PMID: 23118926 Free PMC article.
Mycophenolate mofetil enhances the negative effects of sirolimus and tacrolimus on rat kidney cell metabolism.
Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Klawitter J, et al. Among authors: christians u. PLoS One. 2014 Jan 30;9(1):e86202. doi: 10.1371/journal.pone.0086202. eCollection 2014. PLoS One. 2014. PMID: 24497939 Free PMC article.
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