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Relationship of the 37,000- and 40,000-M(r) tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512).
Payton MA, Hawkes CJ, Christie MR. Payton MA, et al. Among authors: christie mr. J Clin Invest. 1995 Sep;96(3):1506-11. doi: 10.1172/JCI118188. J Clin Invest. 1995. PMID: 7657822 Free PMC article.
The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion.
Harashima S, Clark A, Christie MR, Notkins AL. Harashima S, et al. Among authors: christie mr. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8704-9. doi: 10.1073/pnas.0408887102. Epub 2005 Jun 6. Proc Natl Acad Sci U S A. 2005. PMID: 15939893 Free PMC article.
Failure to detect anti-idiotypic antibodies in the autoimmune response to IA-2 in Type 1 diabetes.
Richardson CC, McLaughlin KA, Brown TJ, Morgan D, Feltbower R, Powell M, Furmaniak J, Rees Smith B, Christie MR. Richardson CC, et al. Among authors: christie mr. Autoimmunity. 2013 Sep;46(6):375-81. doi: 10.3109/08916934.2013.773978. Autoimmunity. 2013. PMID: 24001205
Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes.
Richardson CC, McLaughlin KA, Morgan D, Feltbower RG, Christie MR. Richardson CC, et al. Among authors: christie mr. Diabetologia. 2016 Feb;59(2):334-40. doi: 10.1007/s00125-015-3803-5. Epub 2015 Nov 13. Diabetologia. 2016. PMID: 26564179 Free PMC article.
Relationships between major epitopes of the IA-2 autoantigen in Type 1 diabetes: Implications for determinant spreading.
McLaughlin KA, Richardson CC, Williams S, Bonifacio E, Morgan D, Feltbower RG, Powell M, Rees Smith B, Furmaniak J, Christie MR. McLaughlin KA, et al. Among authors: christie mr. Clin Immunol. 2015 Oct;160(2):226-36. doi: 10.1016/j.clim.2015.06.002. Epub 2015 Jun 9. Clin Immunol. 2015. PMID: 26071317
Two distinctly HLA-associated contiguous linear epitopes uniquely expressed within the islet antigen 2 molecule are major autoantibody epitopes of the diabetes-specific tyrosine phosphatase-like protein autoantigens.
Bearzatto M, Naserke H, Piquer S, Koczwara K, Lampasona V, Williams A, Christie MR, Bingley PJ, Ziegler AG, Bonifacio E. Bearzatto M, et al. Among authors: christie mr. J Immunol. 2002 Apr 15;168(8):4202-8. doi: 10.4049/jimmunol.168.8.4202. J Immunol. 2002. PMID: 11937581
Mapping of epitopes for autoantibodies to the type 1 diabetes autoantigen IA-2 by peptide phage display and molecular modeling: overlap of antibody and T cell determinants.
Dromey JA, Weenink SM, Peters GH, Endl J, Tighe PJ, Todd I, Christie MR. Dromey JA, et al. Among authors: christie mr. J Immunol. 2004 Apr 1;172(7):4084-90. doi: 10.4049/jimmunol.172.7.4084. J Immunol. 2004. PMID: 15034020
Antibodies to a Mr-64,000 islet cell protein in Swedish children with newly diagnosed type 1 (insulin-dependent) diabetes.
Christie M, Landin-Olsson M, Sundkvist G, Dahlquist G, Lernmark A, Baekkeskov S. Christie M, et al. Diabetologia. 1988 Aug;31(8):597-602. doi: 10.1007/BF00264766. Diabetologia. 1988. PMID: 3065114
Human monoclonal antibodies isolated from type I diabetes patients define multiple epitopes in the protein tyrosine phosphatase-like IA-2 antigen.
Kolm-Litty V, Berlo S, Bonifacio E, Bearzatto M, Engel AM, Christie M, Ziegler AG, Wild T, Endl J. Kolm-Litty V, et al. J Immunol. 2000 Oct 15;165(8):4676-84. doi: 10.4049/jimmunol.165.8.4676. J Immunol. 2000. PMID: 11035111
Identification of Tetraspanin-7 as a Target of Autoantibodies in Type 1 Diabetes.
McLaughlin KA, Richardson CC, Ravishankar A, Brigatti C, Liberati D, Lampasona V, Piemonti L, Morgan D, Feltbower RG, Christie MR. McLaughlin KA, et al. Among authors: christie mr. Diabetes. 2016 Jun;65(6):1690-8. doi: 10.2337/db15-1058. Epub 2016 Mar 7. Diabetes. 2016. PMID: 26953162
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