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A specific microbial consortium enhances Th1 immunity, improves LCMV viral clearance but aggravates LCMV disease pathology in mice.
Kolland D, Kuhlmann M, de Almeida GP, Köhler A, Arifovic A, von Strempel A, Pourjam M, Bolsega S, Wurmser C, Steiger K, Basic M, Neuhaus K, Schmidt-Weber CB, Stecher B, Zehn D, Ohnmacht C. Kolland D, et al. Among authors: wurmser c. Nat Commun. 2025 Apr 25;16(1):3902. doi: 10.1038/s41467-025-59073-x. Nat Commun. 2025. PMID: 40274773 Free PMC article.
Precursors of exhausted T cells are pre-emptively formed in acute infection.
Chu T, Wu M, Hoellbacher B, de Almeida GP, Wurmser C, Berner J, Donhauser LV, Gerullis AK, Lin S, Cepeda-Mayorga JD, Kilb II, Bongers L, Toppeta F, Strobl P, Youngblood B, Schulz AM, Zippelius A, Knolle PA, Heinig M, Hackstein CP, Zehn D. Chu T, et al. Among authors: wurmser c. Nature. 2025 Apr;640(8059):782-792. doi: 10.1038/s41586-024-08451-4. Epub 2025 Jan 8. Nature. 2025. PMID: 39778709 Free PMC article.
Pyrimidine de novo synthesis inhibition selectively blocks effector but not memory T cell development.
Scherer S, Oberle SG, Kanev K, Gerullis AK, Wu M, de Almeida GP, Puleston DJ, Baixauli F, Aly L, Greco A, Nizharadze T, Becker NB, Hoesslin MV, Donhauser LV, Berner J, Chu T, McNamara HA, Esencan Z, Roelli P, Wurmser C, Kleiter I, Vehreschild MJGT, Mayer CA, Knolle P, Klingenspor M, Fumagalli V, Iannacone M, Prlic M, Korn T, Pearce EL, Höfer T, Schulz AM, Zehn D. Scherer S, et al. Among authors: wurmser c. Nat Immunol. 2023 Mar;24(3):501-515. doi: 10.1038/s41590-023-01436-x. Epub 2023 Feb 16. Nat Immunol. 2023. PMID: 36797499
35 results