Christopoulos A - Search Results

1

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery.

Christopoulos A. Christopoulos A. Nat Rev Drug Discov. 2002 Mar;1(3):198-210. doi: 10.1038/nrd746. Nat Rev Drug Discov. 2002. PMID: 12120504 Review.

2

[3H]N-methylscopolamine dissociation from muscarine receptors affected by low concentrations of allosteric modulators.

Christopoulos A, Mitchelson F. Christopoulos A, et al. Eur J Pharmacol. 1995 Aug 15;290(3):259-62. doi: 10.1016/0922-4106(95)90002-0. Eur J Pharmacol. 1995. PMID: 7589221

3

Assessment of the allosteric interactions of the bisquaternary heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at M1 and M2 muscarine receptors.

Christopoulos A, Mitchelson F. Christopoulos A, et al. Mol Pharmacol. 1994 Jul;46(1):105-14. Mol Pharmacol. 1994. PMID: 8058045

4

Binding of the muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at cholinoceptor sites.

Christopoulos A, Loiacono R, Mitchelson F. Christopoulos A, et al. Eur J Pharmacol. 1993 Jun 15;246(1):1-8. doi: 10.1016/0922-4106(93)90002-q. Eur J Pharmacol. 1993. PMID: 8354340

5

Interactions of agonists with an allosteric antagonist at muscarinic acetylcholine M2 receptors.

Lanzafame A, Christopoulos A, Mitchelson F. Lanzafame A, et al. Among authors: christopoulos a. Eur J Pharmacol. 1996 Nov 28;316(1):27-32. doi: 10.1016/s0014-2999(96)00639-5. Eur J Pharmacol. 1996. PMID: 8982646

6

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an "infinite dilution" procedure.

Christopoulos A, Lanzafame A, Ziegler A, Mitchelson F. Christopoulos A, et al. Biochem Pharmacol. 1997 Mar 21;53(6):795-800. doi: 10.1016/s0006-2952(96)00814-3. Biochem Pharmacol. 1997. PMID: 9113100

7

Three allosteric modulators act at a common site, distinct from that of competitive antagonists, at muscarinic acetylcholine M2 receptors.

Lanzafame A, Christopoulos A, Mitchelson F. Lanzafame A, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 1997 Jul;282(1):278-85. J Pharmacol Exp Ther. 1997. PMID: 9223565

8

Application of an allosteric ternary complex model to the technique of pharmacological resultant analysis.

Christopoulos A, Mitchelson F. Christopoulos A, et al. J Pharm Pharmacol. 1997 Aug;49(8):781-6. doi: 10.1111/j.2042-7158.1997.tb06112.x. J Pharm Pharmacol. 1997. PMID: 9379356

9

Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors.

Christopoulos A, Mitchelson F. Christopoulos A, et al. Eur J Pharmacol. 1997 Nov 27;339(2-3):153-6. doi: 10.1016/s0014-2999(97)01379-4. Eur J Pharmacol. 1997. PMID: 9473129

10

Allosteric interactions at muscarinic cholinoceptors.

Christopoulos A, Lanzafame A, Mitchelson F. Christopoulos A, et al. Clin Exp Pharmacol Physiol. 1998 Mar-Apr;25(3-4):185-94. doi: 10.1111/j.1440-1681.1998.t01-4-.x. Clin Exp Pharmacol Physiol. 1998. PMID: 9590567 Review.

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