Christopoulos A - Search Results

1

A simple method for quantifying functional selectivity and agonist bias.

Kenakin T, Watson C, Muniz-Medina V, Christopoulos A, Novick S. Kenakin T, et al. Among authors: christopoulos a. ACS Chem Neurosci. 2012 Mar 21;3(3):193-203. doi: 10.1021/cn200111m. Epub 2011 Dec 20. ACS Chem Neurosci. 2012. PMID: 22860188 Free PMC article.

2

Qualitative and quantitative assessment of relative agonist efficacy.

Christopoulos A, El-Fakahany EE. Christopoulos A, et al. Biochem Pharmacol. 1999 Sep 1;58(5):735-48. doi: 10.1016/s0006-2952(99)00087-8. Biochem Pharmacol. 1999. PMID: 10449182 Review.

3

Functional selectivity and classical concepts of quantitative pharmacology.

Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Urban JD, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. doi: 10.1124/jpet.106.104463. Epub 2006 Jun 27. J Pharmacol Exp Ther. 2007. PMID: 16803859 Review.

4

Pharmacology of 5HT(2C) receptor-mediated ERK1/2 phosphorylation: agonist-specific activation pathways and the impact of RNA editing.

Werry TD, Stewart GD, Crouch MF, Watts A, Sexton PM, Christopoulos A. Werry TD, et al. Among authors: christopoulos a. Biochem Pharmacol. 2008 Nov 15;76(10):1276-87. doi: 10.1016/j.bcp.2008.08.024. Epub 2008 Aug 31. Biochem Pharmacol. 2008. PMID: 18812172

5

Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity.

Stewart GD, Valant C, Dowell SJ, Mijaljica D, Devenish RJ, Scammells PJ, Sexton PM, Christopoulos A. Stewart GD, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2009 Oct;331(1):277-86. doi: 10.1124/jpet.109.158667. Epub 2009 Jul 29. J Pharmacol Exp Ther. 2009. PMID: 19641164 Free PMC article.

6

Detection of novel functional selectivity at M3 muscarinic acetylcholine receptors using a Saccharomyces cerevisiae platform.

Stewart GD, Sexton PM, Christopoulos A. Stewart GD, et al. Among authors: christopoulos a. ACS Chem Biol. 2010 Apr 16;5(4):365-75. doi: 10.1021/cb900276p. ACS Chem Biol. 2010. PMID: 20155933

7

Prediction of functionally selective allosteric interactions at an M3 muscarinic acetylcholine receptor mutant using Saccharomyces cerevisiae.

Stewart GD, Sexton PM, Christopoulos A. Stewart GD, et al. Among authors: christopoulos a. Mol Pharmacol. 2010 Aug;78(2):205-14. doi: 10.1124/mol.110.064253. Epub 2010 May 13. Mol Pharmacol. 2010. PMID: 20466821

8

Quantification of functional selectivity at the human α(1A)-adrenoceptor.

Evans BA, Broxton N, Merlin J, Sato M, Hutchinson DS, Christopoulos A, Summers RJ. Evans BA, et al. Among authors: christopoulos a. Mol Pharmacol. 2011 Feb;79(2):298-307. doi: 10.1124/mol.110.067454. Epub 2010 Oct 26. Mol Pharmacol. 2011. PMID: 20978120

9

Analytical pharmacology: the impact of numbers on pharmacology.

Kenakin T, Christopoulos A. Kenakin T, et al. Among authors: christopoulos a. Trends Pharmacol Sci. 2011 Apr;32(4):189-96. doi: 10.1016/j.tips.2011.01.002. Epub 2011 Mar 10. Trends Pharmacol Sci. 2011. PMID: 21397341

10

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation.

Canals M, Lane JR, Wen A, Scammells PJ, Sexton PM, Christopoulos A. Canals M, et al. Among authors: christopoulos a. J Biol Chem. 2012 Jan 2;287(1):650-9. doi: 10.1074/jbc.M111.314278. Epub 2011 Nov 15. J Biol Chem. 2012. PMID: 22086918 Free PMC article.

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