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A simple method for quantifying functional selectivity and agonist bias.
Kenakin T, Watson C, Muniz-Medina V, Christopoulos A, Novick S. Kenakin T, et al. Among authors: christopoulos a. ACS Chem Neurosci. 2012 Mar 21;3(3):193-203. doi: 10.1021/cn200111m. Epub 2011 Dec 20. ACS Chem Neurosci. 2012. PMID: 22860188 Free PMC article.
Functional selectivity and classical concepts of quantitative pharmacology.
Urban JD, Clarke WP, von Zastrow M, Nichols DE, Kobilka B, Weinstein H, Javitch JA, Roth BL, Christopoulos A, Sexton PM, Miller KJ, Spedding M, Mailman RB. Urban JD, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2007 Jan;320(1):1-13. doi: 10.1124/jpet.106.104463. Epub 2006 Jun 27. J Pharmacol Exp Ther. 2007. PMID: 16803859 Review.
Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: implications for ligand screening and functional selectivity.
Stewart GD, Valant C, Dowell SJ, Mijaljica D, Devenish RJ, Scammells PJ, Sexton PM, Christopoulos A. Stewart GD, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2009 Oct;331(1):277-86. doi: 10.1124/jpet.109.158667. Epub 2009 Jul 29. J Pharmacol Exp Ther. 2009. PMID: 19641164 Free PMC article.
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