Christopoulos A - Search Results

1

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells.

Avlani VA, Ma W, Mun HC, Leach K, Delbridge L, Christopoulos A, Conigrave AD. Avlani VA, et al. Among authors: christopoulos a. Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1097-104. doi: 10.1152/ajpendo.00054.2013. Epub 2013 Mar 26. Am J Physiol Endocrinol Metab. 2013. PMID: 23531616 Free article.

2

Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors.

Avlani V, May LT, Sexton PM, Christopoulos A. Avlani V, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2004 Mar;308(3):1062-72. doi: 10.1124/jpet.103.059840. Epub 2004 Jan 7. J Pharmacol Exp Ther. 2004. PMID: 14711931

3

Allosteric modulation of G protein-coupled receptors.

May LT, Avlani VA, Sexton PM, Christopoulos A. May LT, et al. Among authors: christopoulos a. Curr Pharm Des. 2004;10(17):2003-13. doi: 10.2174/1381612043384303. Curr Pharm Des. 2004. PMID: 15279541 Review.

4

G-protein-coupled receptor allosterism: the promise and the problem(s).

Christopoulos A, May LT, Avlani VA, Sexton PM. Christopoulos A, et al. Biochem Soc Trans. 2004 Nov;32(Pt 5):873-7. doi: 10.1042/BST0320873. Biochem Soc Trans. 2004. PMID: 15494038 Review.

5

Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors.

May LT, Avlani VA, Langmead CJ, Herdon HJ, Wood MD, Sexton PM, Christopoulos A. May LT, et al. Among authors: christopoulos a. Mol Pharmacol. 2007 Aug;72(2):463-76. doi: 10.1124/mol.107.037630. Epub 2007 May 24. Mol Pharmacol. 2007. PMID: 17525129

6

Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands.

Avlani VA, Gregory KJ, Morton CJ, Parker MW, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: christopoulos a. J Biol Chem. 2007 Aug 31;282(35):25677-86. doi: 10.1074/jbc.M702311200. Epub 2007 Jun 25. J Biol Chem. 2007. PMID: 17591774 Free article.

7

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology.

Leach K, Sexton PM, Christopoulos A. Leach K, et al. Among authors: christopoulos a. Trends Pharmacol Sci. 2007 Aug;28(8):382-9. doi: 10.1016/j.tips.2007.06.004. Epub 2007 Jul 13. Trends Pharmacol Sci. 2007. PMID: 17629965 Review.

8

The impact of orthosteric radioligand depletion on the quantification of allosteric modulator interactions.

Avlani VA, McLoughlin DJ, Sexton PM, Christopoulos A. Avlani VA, et al. Among authors: christopoulos a. J Pharmacol Exp Ther. 2008 Jun;325(3):927-34. doi: 10.1124/jpet.108.136978. Epub 2008 Mar 5. J Pharmacol Exp Ther. 2008. PMID: 18322151

9

New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug).

Nawaratne V, Leach K, Suratman N, Loiacono RE, Felder CC, Armbruster BN, Roth BL, Sexton PM, Christopoulos A. Nawaratne V, et al. Among authors: christopoulos a. Mol Pharmacol. 2008 Oct;74(4):1119-31. doi: 10.1124/mol.108.049353. Epub 2008 Jul 15. Mol Pharmacol. 2008. PMID: 18628403

10

Molecular mechanisms of action and in vivo validation of an M4 muscarinic acetylcholine receptor allosteric modulator with potential antipsychotic properties.

Leach K, Loiacono RE, Felder CC, McKinzie DL, Mogg A, Shaw DB, Sexton PM, Christopoulos A. Leach K, et al. Among authors: christopoulos a. Neuropsychopharmacology. 2010 Mar;35(4):855-69. doi: 10.1038/npp.2009.194. Epub 2009 Nov 25. Neuropsychopharmacology. 2010. PMID: 19940843 Free PMC article.

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