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Chromatin Domains Go on Repeat in Disease.
Bruneau BG, Nora EP. Bruneau BG, et al. Cell. 2018 Sep 20;175(1):38-40. doi: 10.1016/j.cell.2018.08.068. Cell. 2018. PMID: 30241613 Free article.
In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulation. The findings have important implications for TAD function and mechanisms underlying diseases such as fragile X syndrome and Huntin …
In this issue, Sun et al. show that disease-associated tandem repeats are located to TAD boundaries and affect their insulatio …
A focal domain of extreme demethylation within D4Z4 in FSHD2.
Hartweck LM, Anderson LJ, Lemmers RJ, Dandapat A, Toso EA, Dalton JC, Tawil R, Day JW, van der Maarel SM, Kyba M. Hartweck LM, et al. Neurology. 2013 Jan 22;80(4):392-9. doi: 10.1212/WNL.0b013e31827f075c. Epub 2013 Jan 2. Neurology. 2013. PMID: 23284062 Free PMC article.
Demethylation has been surveyed at 3 restriction enzyme sites in the first repeat and only a single site across the entire array, and current models postulate that a generalized D4Z4 chromatin alteration causes FSHD. ...CONCLUSIONS: These data challenge the simple v …
Demethylation has been surveyed at 3 restriction enzyme sites in the first repeat and only a single site across the entire array, and …
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