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Melanoma genetics and the development of rational therapeutics.
Chudnovsky Y, Khavari PA, Adams AE. Chudnovsky Y, et al. J Clin Invest. 2005 Apr;115(4):813-24. doi: 10.1172/JCI24808. J Clin Invest. 2005. PMID: 15841168 Free PMC article. Review.
Use of human tissue to assess the oncogenic activity of melanoma-associated mutations.
Chudnovsky Y, Adams AE, Robbins PB, Lin Q, Khavari PA. Chudnovsky Y, et al. Nat Genet. 2005 Jul;37(7):745-9. doi: 10.1038/ng1586. Epub 2005 Jun 12. Nat Genet. 2005. PMID: 15951821 Free PMC article.
Oxygen deprivation provokes melanoma.
Adams AE, Chudnovsky Y, Khavari PA. Adams AE, et al. Among authors: chudnovsky y. Nat Med. 2006 Feb;12(2):168-9. doi: 10.1038/nm0206-168. Nat Med. 2006. PMID: 16462795 No abstract available.
SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.
Kim D, Fiske BP, Birsoy K, Freinkman E, Kami K, Possemato RL, Chudnovsky Y, Pacold ME, Chen WW, Cantor JR, Shelton LM, Gui DY, Kwon M, Ramkissoon SH, Ligon KL, Kang SW, Snuderl M, Vander Heiden MG, Sabatini DM. Kim D, et al. Among authors: chudnovsky y. Nature. 2015 Apr 16;520(7547):363-7. doi: 10.1038/nature14363. Epub 2015 Apr 8. Nature. 2015. PMID: 25855294 Free PMC article.
ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.
Chudnovsky Y, Kim D, Zheng S, Whyte WA, Bansal M, Bray MA, Gopal S, Theisen MA, Bilodeau S, Thiru P, Muffat J, Yilmaz OH, Mitalipova M, Woolard K, Lee J, Nishimura R, Sakata N, Fine HA, Carpenter AE, Silver SJ, Verhaak RG, Califano A, Young RA, Ligon KL, Mellinghoff IK, Root DE, Sabatini DM, Hahn WC, Chheda MG. Chudnovsky Y, et al. Cell Rep. 2014 Jan 30;6(2):313-24. doi: 10.1016/j.celrep.2013.12.032. Epub 2014 Jan 16. Cell Rep. 2014. PMID: 24440720 Free PMC article.
Comprehensive genomic profiling reveals inactivating SMARCA4 mutations and low tumor mutational burden in small cell carcinoma of the ovary, hypercalcemic-type.
Lin DI, Chudnovsky Y, Duggan B, Zajchowski D, Greenbowe J, Ross JS, Gay LM, Ali SM, Elvin JA. Lin DI, et al. Among authors: chudnovsky y. Gynecol Oncol. 2017 Dec;147(3):626-633. doi: 10.1016/j.ygyno.2017.09.031. Epub 2017 Nov 6. Gynecol Oncol. 2017. PMID: 29102090
Detection of Crizotinib-Sensitive Lung Adenocarcinomas With MET, ALK, and ROS1 Genomic Alterations via Comprehensive Genomic Profiling.
Le X, Freed JA, VanderLaan PA, Huberman MS, Rangachari D, Jorge SE, Lucena-Araujo AR, Kobayashi SS, Balasubramanian S, He J, Chudnovsky Y, Miller VA, Ali SM, Costa DB. Le X, et al. Among authors: chudnovsky y. Clin Lung Cancer. 2015 Sep;16(5):e105-9. doi: 10.1016/j.cllc.2015.03.002. Epub 2015 Mar 25. Clin Lung Cancer. 2015. PMID: 25922291 Free PMC article.
Comprehensive Genomic Profiling of 282 Pediatric Low- and High-Grade Gliomas Reveals Genomic Drivers, Tumor Mutational Burden, and Hypermutation Signatures.
Johnson A, Severson E, Gay L, Vergilio JA, Elvin J, Suh J, Daniel S, Covert M, Frampton GM, Hsu S, Lesser GJ, Stogner-Underwood K, Mott RT, Rush SZ, Stanke JJ, Dahiya S, Sun J, Reddy P, Chalmers ZR, Erlich R, Chudnovsky Y, Fabrizio D, Schrock AB, Ali S, Miller V, Stephens PJ, Ross J, Crawford JR, Ramkissoon SH. Johnson A, et al. Among authors: chudnovsky y. Oncologist. 2017 Dec;22(12):1478-1490. doi: 10.1634/theoncologist.2017-0242. Epub 2017 Sep 14. Oncologist. 2017. PMID: 28912153 Free PMC article.
Effect of a Collaboration Between a Health Plan, Oncology Practice, and Comprehensive Genomic Profiling Company from the Payer Perspective.
Reitsma M, Fox J, Borre PV, Cavanaugh M, Chudnovsky Y, Erlich RL, Gribbin TE, Anhorn R. Reitsma M, et al. Among authors: chudnovsky y. J Manag Care Spec Pharm. 2019 May;25(5):601-611. doi: 10.18553/jmcp.2019.18309. Epub 2019 Jan 11. J Manag Care Spec Pharm. 2019. PMID: 30632889 Free article. Clinical Trial.
A case of advanced infantile myofibromatosis harboring a novel MYH10-RET fusion.
Rosenzweig M, Ali SM, Wong V, Schrock AB, Laetsch TW, Ahrens W, Heilmann A, Morley S, Chudnovsky Y, Erlich RL, Wang K, Stephens PJ, Ross JS, Miller VA, Oesterheld J. Rosenzweig M, et al. Among authors: chudnovsky y. Pediatr Blood Cancer. 2017 Jul;64(7). doi: 10.1002/pbc.26377. Epub 2016 Dec 28. Pediatr Blood Cancer. 2017. PMID: 28028925 No abstract available.
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