Chuprun JK - Search Results

1

Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.

Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ. Thal DM, et al. Among authors: chuprun jk. ACS Chem Biol. 2012 Nov 16;7(11):1830-9. doi: 10.1021/cb3003013. Epub 2012 Aug 21. ACS Chem Biol. 2012. PMID: 22882301 Free PMC article.

2

Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction.

Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, Tesmer JJ, Koch WJ. Schumacher SM, et al. Among authors: chuprun jk. Sci Transl Med. 2015 Mar 4;7(277):277ra31. doi: 10.1126/scitranslmed.aaa0154. Sci Transl Med. 2015. PMID: 25739765 Free PMC article.

3

Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms.

Brinks H, Boucher M, Gao E, Chuprun JK, Pesant S, Raake PW, Huang ZM, Wang X, Qiu G, Gumpert A, Harris DM, Eckhart AD, Most P, Koch WJ. Brinks H, et al. Among authors: chuprun jk. Circ Res. 2010 Oct 29;107(9):1140-9. doi: 10.1161/CIRCRESAHA.110.221010. Epub 2010 Sep 2. Circ Res. 2010. PMID: 20814022 Free PMC article.

4

GRK2 in the heart: a GPCR kinase and beyond.

Huang ZM, Gao E, Chuprun JK, Koch WJ. Huang ZM, et al. Among authors: chuprun jk. Antioxid Redox Signal. 2014 Nov 10;21(14):2032-43. doi: 10.1089/ars.2014.5876. Epub 2014 May 13. Antioxid Redox Signal. 2014. PMID: 24702056 Free PMC article. Review.

5

The evolving impact of g protein-coupled receptor kinases in cardiac health and disease.

Sato PY, Chuprun JK, Schwartz M, Koch WJ. Sato PY, et al. Among authors: chuprun jk. Physiol Rev. 2015 Apr;95(2):377-404. doi: 10.1152/physrev.00015.2014. Physiol Rev. 2015. PMID: 25834229 Free PMC article. Review.

6

Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy.

Traynham CJ, Cannavo A, Zhou Y, Vouga AG, Woodall BP, Hullmann J, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ. Traynham CJ, et al. Among authors: chuprun jk. Circ Res. 2015 Dec 4;117(12):1001-12. doi: 10.1161/CIRCRESAHA.115.306961. Epub 2015 Oct 29. Circ Res. 2015. PMID: 26515328 Free PMC article.

7

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

Martini JS, Raake P, Vinge LE, DeGeorge BR Jr, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Martini JS, et al. Among authors: chuprun jk. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12457-62. doi: 10.1073/pnas.0803153105. Epub 2008 Aug 18. Proc Natl Acad Sci U S A. 2008. PMID: 18711143 Free PMC article.

8

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ. Ciccarelli M, et al. Among authors: chuprun jk. Circulation. 2011 May 10;123(18):1953-62. doi: 10.1161/CIRCULATIONAHA.110.988642. Epub 2011 Apr 25. Circulation. 2011. PMID: 21518983 Free PMC article.

9

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.

Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ. Chen M, et al. Among authors: chuprun jk. Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6. Circ Res. 2013. PMID: 23467820 Free PMC article.

10

Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury.

Huang ZM, Gao E, Fonseca FV, Hayashi H, Shang X, Hoffman NE, Chuprun JK, Tian X, Tilley DG, Madesh M, Lefer DJ, Stamler JS, Koch WJ. Huang ZM, et al. Among authors: chuprun jk. Sci Signal. 2013 Oct 29;6(299):ra95. doi: 10.1126/scisignal.2004225. Sci Signal. 2013. PMID: 24170934 Free PMC article.

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