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Reporter mice and drug discovery and development.
Maggi A, Ciana P. Maggi A, et al. Nat Rev Drug Discov. 2005 Mar;4(3):249-55. doi: 10.1038/nrd1661. Nat Rev Drug Discov. 2005. PMID: 15738979 Review.
Engineering of a mouse for the in vivo profiling of estrogen receptor activity.
Ciana P, Di Luccio G, Belcredito S, Pollio G, Vegeto E, Tatangelo L, Tiveron C, Maggi A. Ciana P, et al. Mol Endocrinol. 2001 Jul;15(7):1104-13. doi: 10.1210/mend.15.7.0658. Mol Endocrinol. 2001. PMID: 11435611
Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2.
Belcredito S, Vegeto E, Brusadelli A, Ghisletti S, Mussi P, Ciana P, Maggi A. Belcredito S, et al. Brain Res Brain Res Rev. 2001 Nov;37(1-3):335-42. doi: 10.1016/s0165-0173(01)00138-2. Brain Res Brain Res Rev. 2001. PMID: 11744098 Review.
Isomer-specific activity of dichlorodyphenyltrichloroethane with estrogen receptor in adult and suckling estrogen reporter mice.
Di Lorenzo D, Villa R, Biasiotto G, Belloli S, Ruggeri G, Albertini A, Apostoli P, Raviscioni M, Ciana P, Maggi A. Di Lorenzo D, et al. Endocrinology. 2002 Dec;143(12):4544-51. doi: 10.1210/en.2002-220448. Endocrinology. 2002. PMID: 12446581
The DDT isomers p,p'-DDT [1,1,1-trichloro2,2-bis(p-chlorophenyl) ethane] and o,p'-DDT [1,1,1-trichloro-2(p-chlorophenyl)-2-(o-chlorophenyl) ethane] were specifically selected as a weak and a strong estrogen, respectively. ...In all the organs an …
The DDT isomers p,p'-DDT [1,1,1-trichloro2,2-bis(p-chlorophenyl) ethane] and o,p'-DDT [1,1,1-trichloro-2(p
In vivo imaging of transcriptionally active estrogen receptors.
Ciana P, Raviscioni M, Mussi P, Vegeto E, Que I, Parker MG, Lowik C, Maggi A. Ciana P, et al. Nat Med. 2003 Jan;9(1):82-6. doi: 10.1038/nm809. Epub 2002 Dec 16. Nat Med. 2003. PMID: 12483206
Techniques: reporter mice - a new way to look at drug action.
Maggi A, Ottobrini L, Biserni A, Lucignani G, Ciana P. Maggi A, et al. Trends Pharmacol Sci. 2004 Jun;25(6):337-42. doi: 10.1016/j.tips.2004.04.007. Trends Pharmacol Sci. 2004. PMID: 15165750 Review.
The ERE-luc reporter mouse.
Ciana P, Mussi P, Raviscioni M, Biserni A, Ottobrini L, Vegeto E, Maggi A. Ciana P, et al. Ernst Schering Res Found Workshop. 2004;(46):151-68. doi: 10.1007/978-3-662-05386-7_10. Ernst Schering Res Found Workshop. 2004. PMID: 15248510 Review. No abstract available.
Target-specific action of organochlorine compounds in reproductive and nonreproductive tissues of estrogen-reporter male mice.
Villa R, Bonetti E, Penza ML, Iacobello C, Bugari G, Bailo M, Parolini O, Apostoli P, Caimi L, Ciana P, Maggi A, Di Lorenzo D. Villa R, et al. Toxicol Appl Pharmacol. 2004 Dec 1;201(2):137-48. doi: 10.1016/j.taap.2004.05.007. Toxicol Appl Pharmacol. 2004. PMID: 15541753
Three weak estrogens were studied: p,p'DDT [1,1,1-trichloro2,2-bis(p-chlorophenyl) ethane], p,p'DDE [1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene], and betaBHC [beta-benzene-hexachloride]. ...During fasting, betaBHC, p,p'DDT …
Three weak estrogens were studied: p,p'DDT [1,1,1-trichloro2,2-bis(p-chlorophenyl) ethane], p,p'DDE [1,1- …
Activation of brain estrogen receptors in mice lactating from mothers exposed to DDT.
Mussi P, Ciana P, Raviscioni M, Villa R, Regondi S, Agradi E, Maggi A, Di Lorenzo D. Mussi P, et al. Brain Res Bull. 2005 Apr 15;65(3):241-7. doi: 10.1016/j.brainresbull.2004.11.016. Epub 2004 Dec 18. Brain Res Bull. 2005. PMID: 15811587
Estrogenic activities in rodent estrogen-free diets.
Ciana P, Brena A, Sparaciari P, Bonetti E, Di Lorenzo D, Maggi A. Ciana P, et al. Endocrinology. 2005 Dec;146(12):5144-50. doi: 10.1210/en.2005-0660. Epub 2005 Sep 8. Endocrinology. 2005. PMID: 16150910
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