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Inhibition of MDR1 activity in vitro by a novel class of diltiazem analogues: toward new candidates.
Viale M, Cordazzo C, Cosimelli B, de Totero D, Castagnola P, Aiello C, Severi E, Petrillo G, Cianfriglia M, Spinelli D. Viale M, et al. J Med Chem. 2009 Jan 22;52(2):259-66. doi: 10.1021/jm801195k. J Med Chem. 2009. PMID: 19093883
The reversal of multidrug resistance by 22 molecules [8-aryl-8-hydroxy-5-R'-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (1a-i) and 8-aryl-8-alkoxy-5-methyl-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (2a-m)] related to myocardial-calcium-channel-modulator diltiazem w …
The reversal of multidrug resistance by 22 molecules [8-aryl-8-hydroxy-5-R'-8H-[1,4]thiazino[3,4-c][1,2,4]oxadiazol-3-ones (1a-i) and 8-aryl …
A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells.
Turella P, Filomeni G, Dupuis ML, Ciriolo MR, Molinari A, De Maria F, Tombesi M, Cianfriglia M, Federici G, Ricci G, Caccuri AM. Turella P, et al. J Biol Chem. 2006 Aug 18;281(33):23725-32. doi: 10.1074/jbc.M604372200. Epub 2006 Jun 12. J Biol Chem. 2006. PMID: 16769721
HIV-1 integrase inhibitors are substrates for the multidrug transporter MDR1-P-glycoprotein.
Cianfriglia M, Dupuis ML, Molinari A, Verdoliva A, Costi R, Galluzzo CM, Andreotti M, Cara A, Di Santo R, Palmisano L. Cianfriglia M, et al. Retrovirology. 2007 Mar 7;4:17. doi: 10.1186/1742-4690-4-17. Retrovirology. 2007. PMID: 17343726 Free PMC article.
Raltegravir does not revert efflux activity of MDR1-P-glycoprotein in human MDR cells.
Dupuis ML, Ascione A, Palmisano L, Vella S, Cianfriglia M. Dupuis ML, et al. Among authors: cianfriglia m. BMC Pharmacol Toxicol. 2013 Sep 20;14:47. doi: 10.1186/2050-6511-14-47. BMC Pharmacol Toxicol. 2013. PMID: 24053678 Free PMC article.
P-glycoprotein binds to ezrin at amino acid residues 149-242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma.
Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, Cecchetti S, Cianfriglia M, Fais S. Brambilla D, et al. Int J Cancer. 2012 Jun 15;130(12):2824-34. doi: 10.1002/ijc.26285. Epub 2011 Oct 20. Int J Cancer. 2012. PMID: 21780101
The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor.
Riccioni R, Dupuis ML, Bernabei M, Petrucci E, Pasquini L, Mariani G, Cianfriglia M, Testa U. Riccioni R, et al. Blood Cells Mol Dis. 2010 Jun 15;45(1):86-92. doi: 10.1016/j.bcmd.2010.03.008. Epub 2010 May 4. Blood Cells Mol Dis. 2010. PMID: 20444629
Multidrug transporter proteins and cellular factors involved in free and mAb linked calicheamicin-gamma1 (gentuzumab ozogamicin, GO) resistance and in the selection of GO resistant variants of the HL60 AML cell line.
Cianfriglia M, Mallano A, Ascione A, Dupuis ML. Cianfriglia M, et al. Int J Oncol. 2010 Jun;36(6):1513-20. doi: 10.3892/ijo_00000638. Int J Oncol. 2010. PMID: 20428776
The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells.
Ascione A, Cianfriglia M, Dupuis ML, Mallano A, Sau A, Pellizzari Tregno F, Pezzola S, Caccuri AM. Ascione A, et al. Cancer Chemother Pharmacol. 2009 Jul;64(2):419-24. doi: 10.1007/s00280-009-0960-6. Epub 2009 Mar 15. Cancer Chemother Pharmacol. 2009. PMID: 19288261
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