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The ubiquitin system for protein degradation.
Hershko A, Ciechanover A. Hershko A, et al. Among authors: ciechanover a. Annu Rev Biochem. 1992;61:761-807. doi: 10.1146/annurev.bi.61.070192.003553. Annu Rev Biochem. 1992. PMID: 1323239 Review. No abstract available.
Purification and characterization of a novel protein that is required for degradation of N-alpha-acetylated proteins by the ubiquitin system.
Gonen H, Schwartz AL, Ciechanover A. Gonen H, et al. Among authors: ciechanover a. J Biol Chem. 1991 Oct 15;266(29):19221-31. J Biol Chem. 1991. PMID: 1655778
These proteins are degraded in whole lysates in a ubiquitin-dependent manner (Mayer, A. Siegel, N. R., Schwartz, A. L., and Ciechanover, A. (1989) Science 244, 1480-1483). It appears that a protein factor which is specifically required fo …
These proteins are degraded in whole lysates in a ubiquitin-dependent manner (Mayer, A. Siegel, N. R., Schwartz, A. L., …
The ubiquitin-activating enzyme is required for lysosomal degradation of cellular proteins under stress.
Ciechanover A, Gropper R, Schwartz AL. Ciechanover A, et al. Biomed Biochim Acta. 1991;50(4-6):321-32. Biomed Biochim Acta. 1991. PMID: 1801698
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at the restrictive temperature (Ciechanover, A., Finley, D., and Varshavsky, A. (1984) Cell 37, 57-66). ...Analogous resu …
ts85, a cell-line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short-lived proteins at …
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, Brodeur GM. Ciechanover A, et al. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):139-43. doi: 10.1073/pnas.88.1.139. Proc Natl Acad Sci U S A. 1991. PMID: 1846034 Free PMC article.
The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins.
Gropper R, Brandt RA, Elias S, Bearer CF, Mayer A, Schwartz AL, Ciechanover A. Gropper R, et al. Among authors: ciechanover a. J Biol Chem. 1991 Feb 25;266(6):3602-10. J Biol Chem. 1991. PMID: 1847380
ts85, a cell line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short lived proteins at the restrictive temperature (Ciechanover, A., Finley, D., and Varshavsky, A. (1984) Cell 37, 57-66). ...G., Raboy, B., …
ts85, a cell line that harbors a mutant thermolabile ubiquitin-activating enzyme, E1, fails to degrade short lived proteins at …
Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase.
Elias S, Ciechanover A. Elias S, et al. Among authors: ciechanover a. J Biol Chem. 1990 Sep 15;265(26):15511-7. J Biol Chem. 1990. PMID: 2168415
K., Bachmair, A., Wunning, I., Tobias, J. W., Lane, W. S., and Varshavsky, A. (1989) J. ...Proteins with acidic NH2-terminal residues are degraded by the ubiquitin system only following conversion of the acidic residue to a basic residue by the addition of an …
K., Bachmair, A., Wunning, I., Tobias, J. W., Lane, W. S., and Varshavsky, A. (1989) J. ...Proteins with acidic NH2-terminal r …
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