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The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.
Ciechanover A, Brundin P. Ciechanover A, et al. Neuron. 2003 Oct 9;40(2):427-46. doi: 10.1016/s0896-6273(03)00606-8. Neuron. 2003. PMID: 14556719 Review.
Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular processes. ...This raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the developm …
Thus, it is not surprising that ubiquitin-mediated degradation/processing/modification regulates a broad array of basic cellular proc …
The ubiquitin proteasome system and its involvement in cell death pathways.
Bernassola F, Ciechanover A, Melino G. Bernassola F, et al. Cell Death Differ. 2010 Jan;17(1):1-3. doi: 10.1038/cdd.2009.189. Cell Death Differ. 2010. PMID: 20010850 No abstract available.
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.
Levitskaya J, Sharipo A, Leonchiks A, Ciechanover A, Masucci MG. Levitskaya J, et al. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12616-21. doi: 10.1073/pnas.94.23.12616. Proc Natl Acad Sci U S A. 1997. PMID: 9356498 Free PMC article.
We have investigated the influence of the repeat on this process by comparing the degradation of EBNA1, EBNA4, and Gly-Ala containing EBNA4 chimeras in a cell-free system. ...Inhibition was also achieved by insertion of a Pro-Ala coding sequence. The results suggest …
We have investigated the influence of the repeat on this process by comparing the degradation of EBNA1, EBNA4, and Gly-Ala containing EBNA4 …
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, Brodeur GM. Ciechanover A, et al. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):139-43. doi: 10.1073/pnas.88.1.139. Proc Natl Acad Sci U S A. 1991. PMID: 1846034 Free PMC article.
Degradation of other proteins, such as superoxide dismutase, cytochrome c, enolase, RNase A, and ornithine decarboxylase, is not mediated by the ubiquitin cell-free system. ...Furthermore, the relative sensitivity to degradation of various E1A mutants in vivo is also maint …
Degradation of other proteins, such as superoxide dismutase, cytochrome c, enolase, RNase A, and ornithine decarboxylase, is not medi …
Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70.
Bercovich B, Stancovski I, Mayer A, Blumenfeld N, Laszlo A, Schwartz AL, Ciechanover A. Bercovich B, et al. J Biol Chem. 1997 Apr 4;272(14):9002-10. doi: 10.1074/jbc.272.14.9002. J Biol Chem. 1997. PMID: 9083024
Conjugation is catalyzed via a three-step mechanism that involves three distinct enzymes that act successively: E1, E2, and E3. ...E3, to which the substrate is specifically bound, catalyzes formation of a polyubiquitin chain that is anchored to the targeted protein …
Conjugation is catalyzed via a three-step mechanism that involves three distinct enzymes that act successively: E1, E2, and E3. ...E3 …
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates.
Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL, Ciechanover A. Blumenfeld N, et al. J Biol Chem. 1994 Apr 1;269(13):9574-81. J Biol Chem. 1994. PMID: 8144544
Like all members of the E2 family, it generates a thiol ester with ubiquitin that serves as an intermediate in the conjugation reaction. Sequence analysis revealed a significant homology to many known species of E2s. The enzyme generates multiply ubiquitinated prote …
Like all members of the E2 family, it generates a thiol ester with ubiquitin that serves as an intermediate in the conjugation reacti …
Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
Orian A, Whiteside S, Israël A, Stancovski I, Schwartz AL, Ciechanover A. Orian A, et al. J Biol Chem. 1995 Sep 15;270(37):21707-14. doi: 10.1074/jbc.270.37.21707. J Biol Chem. 1995. PMID: 7665588
In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by two distinct genes of the Rel family. p50 is translated as a precursor of 105 kDa. ...J., Goldberg, A. L., and Maniatis, T. (19 …
In most cases, the transcriptional factor NF-kappa B is a heterodimer consisting of two subunits, p50 and p65, which are encoded by t …
Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Mayer A, Gropper R, Schwartz AL, Ciechanover A. Mayer A, et al. J Biol Chem. 1989 Feb 5;264(4):2060-8. J Biol Chem. 1989. PMID: 2914892
We have characterized a temperature sensitive cell cycle arrest mutant cell (ts85) with a thermolabile ubiquitin-activating enzyme (E1; Finley, D., Ciechanover, A., and Varshavsky, A. (1984) Cell 37, 43-55). Following incubation at the restricti …
We have characterized a temperature sensitive cell cycle arrest mutant cell (ts85) with a thermolabile ubiquitin-activating en …
Degradation of proteins with acetylated amino termini by the ubiquitin system.
Mayer A, Siegel NR, Schwartz AL, Ciechanover A. Mayer A, et al. Science. 1989 Jun 23;244(4911):1480-3. doi: 10.1126/science.2544030. Science. 1989. PMID: 2544030
A free NH2-terminal group has been previously shown to be an obligatory signal for recognition and subsequent degradation of proteins in a partially fractionated and reconstituted ubiquitin proteolytic system. ...These results suggest that a novel conjugating
A free NH2-terminal group has been previously shown to be an obligatory signal for recognition and subsequent degradation of proteins
Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-κB Pathway in Melanoma.
Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu S, Nelson N, Kravtsova-Ivantsiv Y, Mills GB, Davies MA, Hoon DSB. Iida Y, et al. Clin Cancer Res. 2017 Aug 15;23(16):4831-4842. doi: 10.1158/1078-0432.CCR-17-0146. Epub 2017 Apr 7. Clin Cancer Res. 2017. PMID: 28389511 Free PMC article.
Purpose: Abnormal activation of the NF-κB pathway induces a more aggressive phenotype of cutaneous melanoma. Understanding the mechanisms involved in melanoma NF-κB activation may identify novel targets for this pathway. KPC1, an E3 ubiquitin ligase, is a regulator …
Purpose: Abnormal activation of the NF-κB pathway induces a more aggressive phenotype of cutaneous melanoma. Understanding the mechan …
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