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Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms.
de Bie P, Ciechanover A. de Bie P, et al. Among authors: ciechanover a. Cell Death Differ. 2011 Sep;18(9):1393-402. doi: 10.1038/cdd.2011.16. Epub 2011 Mar 4. Cell Death Differ. 2011. PMID: 21372847 Free PMC article. Review.
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G. Galluzzi L, et al. Among authors: ciechanover a. Cell Death Differ. 2015 Jan;22(1):58-73. doi: 10.1038/cdd.2014.137. Epub 2014 Sep 19. Cell Death Differ. 2015. PMID: 25236395 Free PMC article. Review.
The ubiquitin proteasome system and its involvement in cell death pathways.
Bernassola F, Ciechanover A, Melino G. Bernassola F, et al. Among authors: ciechanover a. Cell Death Differ. 2010 Jan;17(1):1-3. doi: 10.1038/cdd.2009.189. Cell Death Differ. 2010. PMID: 20010850 No abstract available.
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer.
Melino G, Gallagher E, Aqeilan RI, Knight R, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A, Bernassola F. Melino G, et al. Among authors: ciechanover a. Cell Death Differ. 2008 Jul;15(7):1103-12. doi: 10.1038/cdd.2008.60. Cell Death Differ. 2008. PMID: 18552861 Review.
Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD.
Ciechanover A. Ciechanover A. Cell Death Differ. 2005 Sep;12(9):1167-77. doi: 10.1038/sj.cdd.4401691. Cell Death Differ. 2005. PMID: 16094393 No abstract available.
Degradation of nuclear oncoproteins by the ubiquitin system in vitro.
Ciechanover A, DiGiuseppe JA, Bercovich B, Orian A, Richter JD, Schwartz AL, Brodeur GM. Ciechanover A, et al. Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):139-43. doi: 10.1073/pnas.88.1.139. Proc Natl Acad Sci U S A. 1991. PMID: 1846034 Free PMC article.
Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70.
Bercovich B, Stancovski I, Mayer A, Blumenfeld N, Laszlo A, Schwartz AL, Ciechanover A. Bercovich B, et al. Among authors: ciechanover a. J Biol Chem. 1997 Apr 4;272(14):9002-10. doi: 10.1074/jbc.272.14.9002. J Biol Chem. 1997. PMID: 9083024
Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates.
Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL, Ciechanover A. Blumenfeld N, et al. Among authors: ciechanover a. J Biol Chem. 1994 Apr 1;269(13):9574-81. J Biol Chem. 1994. PMID: 8144544
Ubiquitin-mediated processing of NF-kappa B transcriptional activator precursor p105. Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation.
Orian A, Whiteside S, Israël A, Stancovski I, Schwartz AL, Ciechanover A. Orian A, et al. Among authors: ciechanover a. J Biol Chem. 1995 Sep 15;270(37):21707-14. doi: 10.1074/jbc.270.37.21707. J Biol Chem. 1995. PMID: 7665588
Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Mayer A, Gropper R, Schwartz AL, Ciechanover A. Mayer A, et al. Among authors: ciechanover a. J Biol Chem. 1989 Feb 5;264(4):2060-8. J Biol Chem. 1989. PMID: 2914892
Therefore, mutant cell lines with conditionally altered function(s) of the ubiquitin system can serve as powerful tools in studying the degradation of stable cellular proteins. We have characterized a temperature sensitive cell cycle arrest mutant cell (ts85) with a
Therefore, mutant cell lines with conditionally altered function(s) of the ubiquitin system can serve as powerful tools in studying the degr …
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