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Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85.
Ciechanover A, Finley D, Varshavsky A. Ciechanover A, et al. Cell. 1984 May;37(1):57-66. doi: 10.1016/0092-8674(84)90300-3. Cell. 1984. PMID: 6327060
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors.
Ciechanover A, Schwartz AL, Lodish HF. Ciechanover A, et al. Cell. 1983 Jan;32(1):267-75. doi: 10.1016/0092-8674(83)90517-2. Cell. 1983. PMID: 6297785
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.
Hershko A, Heller H, Elias S, Ciechanover A. Hershko A, et al. Among authors: ciechanover a. J Biol Chem. 1983 Jul 10;258(13):8206-14. J Biol Chem. 1983. PMID: 6305978
One is the ubiquitin-activating enzyme (E1), which is covalently linked to the affinity column in the presence of ATP and can be specifically eluted with AMP and pyrophosphate (Ciechanover, A., Elias, S., Heller, H., and Hershko, A. (1982) J. Biol. Chem. 257, …
One is the ubiquitin-activating enzyme (E1), which is covalently linked to the affinity column in the presence of ATP and can be specificall …
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins.
Hershko A, Eytan E, Ciechanover A, Haas AL. Hershko A, et al. Among authors: ciechanover a. J Biol Chem. 1982 Dec 10;257(23):13964-70. J Biol Chem. 1982. PMID: 6292216
Purification, characterization, and rapid inactivation of thermolabile ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85.
Mayer A, Gropper R, Schwartz AL, Ciechanover A. Mayer A, et al. Among authors: ciechanover a. J Biol Chem. 1989 Feb 5;264(4):2060-8. J Biol Chem. 1989. PMID: 2914892
Therefore, mutant cell lines with conditionally altered function(s) of the ubiquitin system can serve as powerful tools in studying the degradation of stable cellular proteins. We have characterized a temperature sensitive cell cycle arrest mutant cell (ts85) with a
Therefore, mutant cell lines with conditionally altered function(s) of the ubiquitin system can serve as powerful tools in studying the degr …
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent.
Rosenberg-Hasson Y, Bercovich Z, Ciechanover A, Kahana C. Rosenberg-Hasson Y, et al. Among authors: ciechanover a. Eur J Biochem. 1989 Nov 6;185(2):469-74. doi: 10.1111/j.1432-1033.1989.tb15138.x. Eur J Biochem. 1989. PMID: 2555193
Non-canonical ubiquitin-based signals for proteasomal degradation.
Kravtsova-Ivantsiv Y, Ciechanover A. Kravtsova-Ivantsiv Y, et al. Among authors: ciechanover a. J Cell Sci. 2012 Feb 1;125(Pt 3):539-48. doi: 10.1242/jcs.093567. J Cell Sci. 2012. PMID: 22389393 Review.
FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination.
Buchsbaum S, Bercovich B, Ciechanover A. Buchsbaum S, et al. Among authors: ciechanover a. Mol Biol Cell. 2012 Jan;23(1):225-32. doi: 10.1091/mbc.E11-07-0609. Epub 2011 Nov 9. Mol Biol Cell. 2012. PMID: 22072791 Free PMC article.
Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting.
Ciechanover A. Ciechanover A. Cell Death Differ. 2005 Sep;12(9):1178-90. doi: 10.1038/sj.cdd.4401692. Cell Death Differ. 2005. PMID: 16094394 Review.
The ubiquitin-proteasome proteolytic pathway.
Ciechanover A. Ciechanover A. Cell. 1994 Oct 7;79(1):13-21. doi: 10.1016/0092-8674(94)90396-4. Cell. 1994. PMID: 7923371 Review. No abstract available.
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