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Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD.
Carnevale-Schianca F, Cignetti A, Capaldi A, Vitaggio K, Vallario A, Ricchiardi A, Sperti E, Ferraris R, Gatti M, Grignani G, Rota-Scalabrini D, Geuna M, Fizzotti M, Sangiolo D, Sottile A, De Rosa G, Bucci AR, Lambertenghi-Deliliers G, Benedetti E, Nash R, Aglietta M. Carnevale-Schianca F, et al. Among authors: cignetti a. Blood. 2006 May 1;107(9):3795-803. doi: 10.1182/blood-2005-10-3945. Epub 2006 Jan 10. Blood. 2006. PMID: 16403911 Free article.
Ex vivo allogeneic stimulation significantly improves expansion of cytokine-induced killer cells without increasing their alloreactivity across HLA barriers.
Todorovic M, Mesiano G, Gammaitoni L, Leuci V, Giraudo Diego L, Cammarata C, Jordaney N, Carnevale-Schianca F, Gallo S, Fagioli F, Piacibello W, Elia AR, Pignochino Y, Dell'aglio C, Grignani G, Cignetti A, Aglietta M, Sangiolo D. Todorovic M, et al. Among authors: cignetti a. J Immunother. 2012 Sep;35(7):579-86. doi: 10.1097/CJI.0b013e31826b1fd9. J Immunother. 2012. PMID: 22892454
Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers.
Sangiolo D, Martinuzzi E, Todorovic M, Vitaggio K, Vallario A, Jordaney N, Carnevale-Schianca F, Capaldi A, Geuna M, Casorzo L, Nash RA, Aglietta M, Cignetti A. Sangiolo D, et al. Among authors: cignetti a. Int Immunol. 2008 Jul;20(7):841-8. doi: 10.1093/intimm/dxn042. Epub 2008 May 9. Int Immunol. 2008. PMID: 18469328
Transient proteasome inhibition as a strategy to enhance lentiviral transduction of hematopoietic CD34(+) cells and T lymphocytes: implications for the use of low viral doses and large-size vectors.
Leuci V, Mesiano G, Gammaitoni L, Cammarata C, Capellero S, Todorovic M, Jordaney N, Circosta P, Elia A, Lesnikova M, Georges GE, Piacibello W, Fagioli F, Cignetti A, Aglietta M, Sangiolo D. Leuci V, et al. Among authors: cignetti a. J Biotechnol. 2011 Dec 10;156(3):218-26. doi: 10.1016/j.jbiotec.2011.09.001. Epub 2011 Sep 10. J Biotechnol. 2011. PMID: 21933686
Cytokine-induced killer cells engineered with exogenous T-cell receptors directed against melanoma antigens: enhanced efficacy of effector cells endowed with a double mechanism of tumor recognition.
Elia AR, Circosta P, Sangiolo D, Bonini C, Gammaitoni L, Mastaglio S, Genovese P, Geuna M, Avolio F, Inghirami G, Tarella C, Cignetti A. Elia AR, et al. Among authors: cignetti a. Hum Gene Ther. 2015 Apr;26(4):220-31. doi: 10.1089/hum.2014.112. Epub 2015 Apr 13. Hum Gene Ther. 2015. PMID: 25758764
Post-Transplant Cyclophosphamide and Tacrolimus-Mycophenolate Mofetil Combination Governs GVHD and Immunosuppression Need, Reducing Late Toxicities in Allogeneic Peripheral Blood Hematopoietic Cell Transplantation from HLA-Matched Donors.
Carnevale-Schianca F, Caravelli D, Gallo S, Becco P, Paruzzo L, Poletto S, Polo A, Mangioni M, Salierno M, Berger M, Pessolano R, Saglio F, Gottardi D, Rota-Scalabrini D, Grignani G, Fizzotti M, Ferrero I, Frascione PMM, D'Ambrosio L, Gaidano V, Gammaitoni L, Sangiolo D, Saglietto A, Vassallo E, Cignetti A, Aglietta M, Fagioli F. Carnevale-Schianca F, et al. Among authors: cignetti a. J Clin Med. 2021 Mar 11;10(6):1173. doi: 10.3390/jcm10061173. J Clin Med. 2021. PMID: 33799685 Free PMC article.
T cell receptor (TCR) gene transfer with lentiviral vectors allows efficient redirection of tumor specificity in naive and memory T cells without prior stimulation of endogenous TCR.
Circosta P, Granziero L, Follenzi A, Vigna E, Stella S, Vallario A, Elia AR, Gammaitoni L, Vitaggio K, Orso F, Geuna M, Sangiolo D, Todorovic M, Giachino C, Cignetti A. Circosta P, et al. Among authors: cignetti a. Hum Gene Ther. 2009 Dec;20(12):1576-88. doi: 10.1089/hum.2009.117. Hum Gene Ther. 2009. PMID: 19678763
Full chimaeric CAR.CIK from patients engrafted after allogeneic haematopoietic cell transplant: Feasibility, anti-leukaemic potential and alloreactivity across major human leukocyte antigen barriers.
Circosta P, Donini C, Gallo S, Giraudo L, Gammaitoni L, Rotolo R, Galvagno F, Capellero S, Basiricò M, Casucci M, Aglietta M, Ferrero I, Fagioli F, Cignetti A, Carnevale-Schianca F, Leuci V, Sangiolo D. Circosta P, et al. Among authors: cignetti a. Br J Haematol. 2023 Jan;200(1):64-69. doi: 10.1111/bjh.18469. Epub 2022 Sep 26. Br J Haematol. 2023. PMID: 36155897 Free PMC article.
74 results