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Discovery of a new series of 5-HT1A receptor agonists.
Franchini S, Prandi A, Sorbi C, Tait A, Baraldi A, Angeli P, Buccioni M, Cilia A, Poggesi E, Fossa P, Brasili L. Franchini S, et al. Among authors: cilia a. Bioorg Med Chem Lett. 2010 Mar 15;20(6):2017-20. doi: 10.1016/j.bmcl.2010.01.030. Epub 2010 Feb 4. Bioorg Med Chem Lett. 2010. PMID: 20185311
1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.
Franchini S, Prandi A, Baraldi A, Sorbi C, Tait A, Buccioni M, Marucci G, Cilia A, Pirona L, Fossa P, Cichero E, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2010 Sep;45(9):3740-51. doi: 10.1016/j.ejmech.2010.05.023. Epub 2010 May 15. Eur J Med Chem. 2010. PMID: 20605276
Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.
Franchini S, Battisti UM, Prandi A, Tait A, Borsari C, Cichero E, Fossa P, Cilia A, Prezzavento O, Ronsisvalle S, Aricò G, Parenti C, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2016 Apr 13;112:1-19. doi: 10.1016/j.ejmech.2016.01.059. Epub 2016 Feb 1. Eur J Med Chem. 2016. PMID: 26874044 Free article.
Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.
Franchini S, Manasieva LI, Sorbi C, Battisti UM, Fossa P, Cichero E, Denora N, Iacobazzi RM, Cilia A, Pirona L, Ronsisvalle S, Aricò G, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2017 Jan 5;125:435-452. doi: 10.1016/j.ejmech.2016.09.050. Epub 2016 Sep 17. Eur J Med Chem. 2017. PMID: 27689727 Free article.
1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.
Franchini S, Sorbi C, Linciano P, Carnevale G, Tait A, Ronsisvalle S, Buccioni M, Del Bello F, Cilia A, Pirona L, Denora N, Iacobazzi RM, Brasili L. Franchini S, et al. Among authors: cilia a. Eur J Med Chem. 2019 Aug 15;176:310-325. doi: 10.1016/j.ejmech.2019.05.024. Epub 2019 May 11. Eur J Med Chem. 2019. PMID: 31112892
Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.
Anighoro A, Graziani D, Bettinelli I, Cilia A, De Toma C, Longhi M, Mangiarotti F, Menegon S, Pirona L, Poggesi E, Riva C, Rastelli G. Anighoro A, et al. Among authors: cilia a. Bioorg Med Chem. 2015 Jul 1;23(13):3040-58. doi: 10.1016/j.bmc.2015.05.008. Epub 2015 May 12. Bioorg Med Chem. 2015. PMID: 26014480
48 results