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Fragile sites: breaking up over a slowdown.
Cimprich KA. Cimprich KA. Curr Biol. 2003 Mar 18;13(6):R231-3. doi: 10.1016/s0960-9822(03)00158-1. Curr Biol. 2003. PMID: 12646149
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints.
Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL, Friend SH. Cliby WA, et al. EMBO J. 1998 Jan 2;17(1):159-69. doi: 10.1093/emboj/17.1.159. EMBO J. 1998. PMID: 9427750 Free PMC article.
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G(1)/S checkpoint activation in response to DNA damage.
Post S, Weng YC, Cimprich K, Chen LB, Xu Y, Lee EY. Post S, et al. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13102-7. doi: 10.1073/pnas.231364598. Epub 2001 Oct 30. Proc Natl Acad Sci U S A. 2001. PMID: 11687627 Free PMC article.
A requirement for replication in activation of the ATR-dependent DNA damage checkpoint.
Lupardus PJ, Byun T, Yee MC, Hekmat-Nejad M, Cimprich KA. Lupardus PJ, et al. Genes Dev. 2002 Sep 15;16(18):2327-32. doi: 10.1101/gad.1013502. Genes Dev. 2002. PMID: 12231621 Free PMC article.
A novel protein activity mediates DNA binding of an ATR-ATRIP complex.
Bomgarden RD, Yean D, Yee MC, Cimprich KA. Bomgarden RD, et al. J Biol Chem. 2004 Apr 2;279(14):13346-53. doi: 10.1074/jbc.M311098200. Epub 2004 Jan 14. J Biol Chem. 2004. PMID: 14724280
Checkpoint adaptation; molecular mechanisms uncovered.
Lupardus PJ, Cimprich KA. Lupardus PJ, et al. Cell. 2004 May 28;117(5):555-6. doi: 10.1016/j.cell.2004.05.005. Cell. 2004. PMID: 15163402
G2 damage checkpoints: what is the turn-on?
O'Connell MJ, Cimprich KA. O'Connell MJ, et al. J Cell Sci. 2005 Jan 1;118(Pt 1):1-6. doi: 10.1242/jcs.01626. J Cell Sci. 2005. PMID: 15615778
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