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Page 1
Dietary supplements for dysmenorrhoea.
Pattanittum P, Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, Marjoribanks J. Pattanittum P, et al. Cochrane Database Syst Rev. 2016 Mar 22;3(3):CD002124. doi: 10.1002/14651858.CD002124.pub2. Cochrane Database Syst Rev. 2016. PMID: 27000311 Free PMC article.
Interventions included 12 different herbal medicines (German chamomile (Matricaria chamomilla, M recutita, Chamomilla recutita), cinnamon (Cinnamomum zeylanicum, C. verum), Damask rose (Rosa damascena), dill (Anethum graveolens), fennel (Foeniculum vulgare), …
Interventions included 12 different herbal medicines (German chamomile (Matricaria chamomilla, M recutita, Chamomilla recutita), cinnamon ( …
Efficacy of cinnamon in patients with type II diabetes mellitus: A randomized controlled clinical trial.
Zare R, Nadjarzadeh A, Zarshenas MM, Shams M, Heydari M. Zare R, et al. Clin Nutr. 2019 Apr;38(2):549-556. doi: 10.1016/j.clnu.2018.03.003. Epub 2018 Mar 11. Clin Nutr. 2019. PMID: 29605574 Clinical Trial.
METHODS: The study was designed as a triple-blind placebo-controlled randomized clinical trial, using a parallel design. One hundred and forty patients referred to Diabetes Clinic of Yazd University of Medical Sciences with diagnosis of DM type II were randomly assi …
METHODS: The study was designed as a triple-blind placebo-controlled randomized clinical trial, using a parallel design. One h …
A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS).
Moini Jazani A, Nasimi Doost Azgomi H, Nasimi Doost Azgomi A, Nasimi Doost Azgomi R. Moini Jazani A, et al. Daru. 2019 Dec;27(2):863-877. doi: 10.1007/s40199-019-00312-0. Epub 2019 Nov 18. Daru. 2019. PMID: 31741280 Free PMC article. Review.
RESULTS: According to a multitude of studies, a wide spectrum of herbs can be used to improve various aspects of PCOS. Herbs such as Cinnamomum verum, Trigonella foenum-graecum L., and Vitex agnus-castus can impact on menstrual and ovulatory dysfunctions, obesity, i …
RESULTS: According to a multitude of studies, a wide spectrum of herbs can be used to improve various aspects of PCOS. Herbs such as Cinn …
Effects of Cinnamomum zeylanicum (Ceylon cinnamon) extract on lipid profile, glucose levels and its safety in adults: A randomized, double-blind, controlled trial.
Muthukuda D, de Silva CK, Ajanthan S, Wijesinghe N, Dahanayaka A, Pathmeswaran A. Muthukuda D, et al. PLoS One. 2025 Jan 24;20(1):e0317904. doi: 10.1371/journal.pone.0317904. eCollection 2025. PLoS One. 2025. PMID: 39854533 Free PMC article. Clinical Trial.
However, there are no well-conducted randomized controlled trials that can accurately measure the lipid and glucose-lowering effects of Cinnamomum zeylanicum (C. zeylanicum) extract. This study primarily aimed to evaluate the effect of a standardized C. ze …
However, there are no well-conducted randomized controlled trials that can accurately measure the lipid and glucose-lowering effects of C …
Efficacy and Safety of Cinnamomum zeylanicum (Ceylon cinnamon) for diabetes mellitus: a randomized, double blind, placebo-controlled clinical trial.
Ranasinghe P, Galappatthy P, Constantine GR, Jayawardena R, Weeratunga HD, Premakumara S, Katulanda P. Ranasinghe P, et al. Diabetes Metab Syndr. 2025 Dec;19(12):103357. doi: 10.1016/j.dsx.2025.103357. Epub 2025 Dec 12. Diabetes Metab Syndr. 2025. PMID: 41412108 Clinical Trial.
We assessed the efficacy and safety of Cinnamomum zeylanicum (CZ) extract in individuals with Type 2 Diabetes. METHODS: A total of 210 individuals with Type 2 Diabetes were randomly assigned in equal numbers to two CZ extract groups (250 mg or 500 mg) and one placeb …
We assessed the efficacy and safety of Cinnamomum zeylanicum (CZ) extract in individuals with Type 2 Diabetes. METHODS: A tota …
Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A. Arentz S, et al. Phytother Res. 2017 Sep;31(9):1330-1340. doi: 10.1002/ptr.5858. Epub 2017 Jul 7. Phytother Res. 2017. PMID: 28685911 Free PMC article. Clinical Trial.
The herbal intervention consisted of two tablets. Tablet 1 contained Cinnamomum verum, Glycyrrhiza glabra, Hypericum perforatum and Paeonia lactiflora. Tablet 2 contained Tribulus terrestris. ...
The herbal intervention consisted of two tablets. Tablet 1 contained Cinnamomum verum, Glycyrrhiza glabra, Hypericum perforatu …
Effect of Aqueous Cinnamon Extract on the Postprandial Glycemia Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial.
Rachid AP, Moncada M, Mesquita MF, Brito J, Bernardo MA, Silva ML. Rachid AP, et al. Nutrients. 2022 Apr 10;14(8):1576. doi: 10.3390/nu14081576. Nutrients. 2022. PMID: 35458138 Free PMC article. Clinical Trial.
The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mellitus (DM2) adults. This clinical trial enrolled 36 adults with DM2, randomly allocated in two groups: the control group (n = …
The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mel …
Cinnamon and health.
Gruenwald J, Freder J, Armbruester N. Gruenwald J, et al. Crit Rev Food Sci Nutr. 2010 Oct;50(9):822-34. doi: 10.1080/10408390902773052. Crit Rev Food Sci Nutr. 2010. PMID: 20924865 Review.
Efficacy of cinnamon in reducing anthropometric measurements in individuals with type 2 diabetes: a clinical trial.
Lira Neto JCG, Araújo MFM, Penha JCD, Bezerra MAR, Fernandes BKC, Maranhão TA, Borges JWP, Damasceno MMC. Lira Neto JCG, et al. Rev Bras Enferm. 2025 Jul 11;78(3):e20240380. doi: 10.1590/0034-7167-2024-0380. eCollection 2025. Rev Bras Enferm. 2025. PMID: 40667904 Free PMC article. Clinical Trial.
OBJECTIVES: to evaluate the effectiveness of cinnamon (Cinnamomum verum) in reducing anthropometric measurements in individuals with type 2 diabetes. METHODS: a randomized, triple-blind, placebo-controlled clinical trial was conducted with 140 particip …
OBJECTIVES: to evaluate the effectiveness of cinnamon (Cinnamomum verum) in reducing anthropometric measurements in individual …
Cinnamon for diabetes mellitus.
Leach MJ, Kumar S. Leach MJ, et al. Cochrane Database Syst Rev. 2012 Sep 12;2012(9):CD007170. doi: 10.1002/14651858.CD007170.pub2. Cochrane Database Syst Rev. 2012. PMID: 22972104 Free PMC article.
SEARCH METHODS: Pertinent randomised controlled trials were identified through AARP Ageline, AMED, AMI, BioMed Central gateway, CAM on PubMed, CINAHL, Dissertations Abstracts International, EMBASE, Health Source Nursing/Academic edition, International Pharmaceutical Abstracts, ME …
SEARCH METHODS: Pertinent randomised controlled trials were identified through AARP Ageline, AMED, AMI, BioMed Central gateway, CAM on PubMe …
Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial.
Ranasinghe P, Jayawardena R, Pigera S, Wathurapatha WS, Weeratunga HD, Premakumara GAS, Katulanda P, Constantine GR, Galappaththy P. Ranasinghe P, et al. BMC Complement Altern Med. 2017 Dec 28;17(1):550. doi: 10.1186/s12906-017-2067-7. BMC Complement Altern Med. 2017. PMID: 29282046 Free PMC article. Clinical Trial.
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The p …
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanic …
Effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms: a randomised, placebo-controlled clinical trial.
Taavoni S, Ekbatani NN, Haghani H. Taavoni S, et al. Prz Menopauzalny. 2017 Mar;16(1):19-22. doi: 10.5114/pm.2017.67366. Epub 2017 Apr 26. Prz Menopauzalny. 2017. PMID: 28546803 Free PMC article.
The purpose of this study was to determine the effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms. A randomised, triple-blind, controlled trial design was used for this study. ...Each Aphrodit capsule contained 40 mg of Tribulus terrestri …
The purpose of this study was to determine the effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms. …
To what extent does cinnamon administration improve the glycemic and lipid profiles?
Santos HO, da Silva GAR. Santos HO, et al. Clin Nutr ESPEN. 2018 Oct;27:1-9. doi: 10.1016/j.clnesp.2018.07.011. Epub 2018 Aug 13. Clin Nutr ESPEN. 2018. PMID: 30144878 Review.
The search for articles was based on following keywords: "cinnamon diabetes", "cinnamon diabetes type 2", "cinnamon and diabetes type 2", "Cinnamomum aromaticum", "Cinnamomum cassia", "Cinnamomum verum", "Cinnamomum zeylanicum". ...Two sp …
The search for articles was based on following keywords: "cinnamon diabetes", "cinnamon diabetes type 2", "cinnamon and diabetes type 2", " …
The Effect of Therapeutic Doses of Culinary Spices in Metabolic Syndrome: A Randomized Controlled Trial.
Al Dhaheri AS, Alkhatib DH, Feehan J, Cheikh Ismail L, Apostolopoulos V, Stojanovska L. Al Dhaheri AS, et al. Nutrients. 2024 May 29;16(11):1685. doi: 10.3390/nu16111685. Nutrients. 2024. PMID: 38892617 Free PMC article. Clinical Trial.
Therefore we performed a 12-week double-blind, placebo-controlled, randomized, clinical trial to evaluate the effect of ginger (Zingiber officinale), cinnamon (Cinnamomum), and black seed (Nigella sativa) consumption on blood glucose, lipid profiles, and body …
Therefore we performed a 12-week double-blind, placebo-controlled, randomized, clinical trial to evaluate the effect of ginger …
From type 2 diabetes to antioxidant activity: a systematic review of the safety and efficacy of common and cassia cinnamon bark.
Dugoua JJ, Seely D, Perri D, Cooley K, Forelli T, Mills E, Koren G. Dugoua JJ, et al. Can J Physiol Pharmacol. 2007 Sep;85(9):837-47. doi: 10.1139/Y07-080. Can J Physiol Pharmacol. 2007. PMID: 18066129
Common (Cinnamomum verum, C. zeylanicum) and cassia (C. aromaticum) cinnamon have a long history of use as spices and flavouring agents. ...One randomized clinical trial reported that cassia cinnamon lowered total cholesterol, low-density lipopr …
Common (Cinnamomum verum, C. zeylanicum) and cassia (C. aromaticum) cinnamon have a long history of use as spices and f …
Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.
Ranasinghe P, Galappaththy P, Constantine GR, Jayawardena R, Weeratunga HD, Premakumara S, Katulanda P. Ranasinghe P, et al. Trials. 2017 Sep 29;18(1):446. doi: 10.1186/s13063-017-2192-0. Trials. 2017. PMID: 28962661 Free PMC article. Clinical Trial.
Two doses of Cinnamomum zeylanicum extracts (250 mg and 500 mg of the cinnamon extract) will be used. ...DISCUSSION: We describe the protocol for a clinical trial design evaluating the effects of Cinnamomum zeylanicum (Ceylon cinnamon) in …
Two doses of Cinnamomum zeylanicum extracts (250 mg and 500 mg of the cinnamon extract) will be used. ...DISCUSSION: We descri …
Cinnamon and Cassia Nomenclature Confusion: A Challenge to the Applicability of Clinical Data.
Oketch-Rabah HA, Marles RJ, Brinckmann JA. Oketch-Rabah HA, et al. Clin Pharmacol Ther. 2018 Sep;104(3):435-445. doi: 10.1002/cpt.1162. Epub 2018 Aug 6. Clin Pharmacol Ther. 2018. PMID: 29947417 Review.
Several Cinnamomum species' barks are generally labeled as cinnamon, although only Cinnamomum verum carries the common name of true cinnamon. ...Due to differences in the quality and composition of various Cinnamomum species, safety and efficacy data a …
Several Cinnamomum species' barks are generally labeled as cinnamon, although only Cinnamomum verum carries the common …
Efficacy of Cinnamon as an Adjuvant in Reducing the Glycemic Biomarkers of Type 2 Diabetes Mellitus: A Three-Month, Randomized, Triple-Blind, Placebo-Controlled Clinical Trial.
Lira Neto JCG, Damasceno MMC, Ciol MA, de Freitas RWJF, de Araújo MFM, Teixeira CRS, Carvalho GCN, Lisboa KWSC, Marques RLL, Alencar AMPG, Zanetti ML. Lira Neto JCG, et al. J Am Nutr Assoc. 2022 Mar-Apr;41(3):266-274. doi: 10.1080/07315724.2021.1878967. Epub 2021 Feb 19. J Am Nutr Assoc. 2022. PMID: 33605836 Clinical Trial.
The major aim of this randomized, placebo-controlled, triple-blind clinical trial was to evaluate the efficacy of cinnamon as an adjuvant treatment in reducing glycemic levels in people with type 2 diabetes, compared to a placebo. ...
The major aim of this randomized, placebo-controlled, triple-blind clinical trial was to evaluate the efficacy of cinnamon as …
Cinnamon potential in alleviating early postmenopause symptoms: a randomized clinical trial.
Refaei M, Karami Z, Kazemi F, Moradkhani S, Masoumi SZ, Jenabi E, Jafari M. Refaei M, et al. Menopause. 2024 Dec 1;31(12):1078-1084. doi: 10.1097/GME.0000000000002444. Menopause. 2024. PMID: 39579099 Clinical Trial.
METHODS: A randomized, triple-blind, parallel clinical trial was conducted on 60 postmenopausal women in the health centers of Hamadan, Iran. ...
METHODS: A randomized, triple-blind, parallel clinical trial was conducted on 60 postmenopausal women in the health centers of …
Effectiveness of cinnamon in the reduction of lipid levels in people with diabetes: a randomized clinical trial.
Lira Neto JCG, Araújo MFM, Araújo AVEC, Figueira JNR, Maranhão TA, Damasceno MMC. Lira Neto JCG, et al. Rev Gaucha Enferm. 2023 Oct 27;44:e20230051. doi: 10.1590/1983-1447.2023.20230051.en. eCollection 2023. Rev Gaucha Enferm. 2023. PMID: 37909519 Free article. Clinical Trial. English, Portuguese.
OBJECTIVE: To evaluate the effectiveness of cinnamon in reducing lipid levels in people with diabetes. METHOD: Randomized clinical trial of parallel groups, triple-blind, conducted in Basic Health Units in the state of Piaui in 2019. ...
OBJECTIVE: To evaluate the effectiveness of cinnamon in reducing lipid levels in people with diabetes. METHOD: Randomized clinical …
Analysis of the effectiveness of cinnamon (Cinnamomum verum) in the reduction of glycemic and lipidic levels of adults with type 2 diabetes: A study protocol.
Neto JCGL, Damasceno MMC, Ciol MA, de Freitas RWJF, de Araújo MFM, de Souza Teixeira CR, Carvalho GCN, de Siqueira Coelho Lisboa KW, de Souza DF, de Menezes Nogueira J, Marques RLL, Alencar AMPG. Neto JCGL, et al. Medicine (Baltimore). 2020 Jan;99(1):e18553. doi: 10.1097/MD.0000000000018553. Medicine (Baltimore). 2020. PMID: 31895796 Free PMC article.
OBJECTIVE: To analyze the effectiveness of 3 grams of cinnamon (Cinnamomum verum) per day for 90 days in reducing glycemic and lipid levels in adults with T2DM compared with placebo METHODS:: A randomized, double-blind, placebo-controlled, phase II trial, which will …
OBJECTIVE: To analyze the effectiveness of 3 grams of cinnamon (Cinnamomum verum) per day for 90 days in reducing glycemic and …
The effect of clomiphene citrate, herbal mixture, and herbal mixture along with clomiphene citrate on clinical and para-clinical parameters in infertile women with polycystic ovary syndrome: a randomized controlled clinical trial.
Ainehchi N, Khaki A, Ouladsahebmadarek E, Hammadeh M, Farzadi L, Farshbaf-Khalili A, Asnaashari S, Khamnei HJ, Khaki AA, Shokoohi M. Ainehchi N, et al. Arch Med Sci. 2020 Feb 25;16(6):1304-1318. doi: 10.5114/aoms.2020.93271. eCollection 2020. Arch Med Sci. 2020. PMID: 33224329 Free PMC article.
INTRODUCTION: To evaluate the effect of a herbal mixture (i.e., Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, and Citrus sinensis) alone and in combination with clomiphene citrate (CC) compared to CC on the treatment of polycystic ovary syndrome (PCOS) …
INTRODUCTION: To evaluate the effect of a herbal mixture (i.e., Mentha spicata, Zingiber officinale, Cinnamomum zeylanicum, an …
Cinnamon supplementation in patients with type 2 diabetes mellitus.
Pham AQ, Kourlas H, Pham DQ. Pham AQ, et al. Pharmacotherapy. 2007 Apr;27(4):595-9. doi: 10.1592/phco.27.4.595. Pharmacotherapy. 2007. PMID: 17381386 Review.
We found two prospective, randomized, double-blind, placebo-controlled, peer-reviewed clinical trials and one prospective, placebo-controlled, peer-reviewed clinical trial that evaluated the efficacy of cinnamon supplementation in patients with type 2 diabetes; a to …
We found two prospective, randomized, double-blind, placebo-controlled, peer-reviewed clinical trials and one prospective, placebo-controlle …
Cinnamon intake lowers fasting blood glucose: meta-analysis.
Davis PA, Yokoyama W. Davis PA, et al. J Med Food. 2011 Sep;14(9):884-9. doi: 10.1089/jmf.2010.0180. Epub 2011 Apr 11. J Med Food. 2011. PMID: 21480806 Review.
Cinnamon, the dry bark and twig of Cinnamomum spp., is a rich botanical source of polyphenolics that has been used for centuries in Chinese medicine and has been shown to affect blood glucose and insulin signaling. ...
Cinnamon, the dry bark and twig of Cinnamomum spp., is a rich botanical source of polyphenolics that has been used for centuries in C …
The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance.
Kirkham S, Akilen R, Sharma S, Tsiami A. Kirkham S, et al. Diabetes Obes Metab. 2009 Dec;11(12):1100-13. doi: 10.1111/j.1463-1326.2009.01094.x. Diabetes Obes Metab. 2009. PMID: 19930003 Review.
METHODS: A systematic electronic literature search using the medical subject headings 'cinnamon' and 'blood glucose' was carried out to include randomized, placebo-controlled in vivo clinical trials using Cinnamomum verum or Cinnamomum cassia conducted betwee …
METHODS: A systematic electronic literature search using the medical subject headings 'cinnamon' and 'blood glucose' was carried out to incl …
Cinnamon (Cinnamomum cassia) water extract improves diarrhea symptoms by changing the gut environment: a randomized controlled trial.
Park SY, Kim YD, Kim MS, Kim KT, Kim JY. Park SY, et al. Food Funct. 2023 Feb 6;14(3):1520-1529. doi: 10.1039/d2fo01835g. Food Funct. 2023. PMID: 36655542 Clinical Trial.
Cinnamon is a spice obtained from the bark of Cinnamomum and contains anti-inflammatory ingredients such as coumarin, cinnamaldehyde, and cinnamic acid. ...
Cinnamon is a spice obtained from the bark of Cinnamomum and contains anti-inflammatory ingredients such as coumarin, cinnamaldehyde, …
A Single Site, Open Label Clinical Trial, Evaluating the Duration, Efficacy, and Safety of a Novel Lip Plumper.
Boen M, Alhaddad M, Guiha I, Wu DP, Goldman MP. Boen M, et al. J Drugs Dermatol. 2018 Sep 1;17(9):999-1004. J Drugs Dermatol. 2018. PMID: 30235388 Clinical Trial.
METHODS: This is a prospective, single center, clinical trial to evaluate the duration, efficacy, and safety of a lip plumping agent in two clinical visits. ...
METHODS: This is a prospective, single center, clinical trial to evaluate the duration, efficacy, and safety of a lip plumping …
The effect of Cinnamon on primary dysmenorrhea: A randomized, double-blind clinical trial.
Jahangirifar M, Taebi M, Dolatian M. Jahangirifar M, et al. Complement Ther Clin Pract. 2018 Nov;33:56-60. doi: 10.1016/j.ctcp.2018.08.001. Epub 2018 Aug 15. Complement Ther Clin Pract. 2018. PMID: 30396627 Clinical Trial.
METHODS: This is a randomized, double-blind clinical trial. The intervention group received Cinnamon (capsules contained 1000 mg cinnamon) and the control group received placebo (capsules contained 1000 mg starch) during the first 72 h of menstruation for two cycles …
METHODS: This is a randomized, double-blind clinical trial. The intervention group received Cinnamon (capsules contained 1000 …
Do Cinnamon Supplements Have a Role in Glycemic Control in Type 2 Diabetes? A Narrative Review.
Costello RB, Dwyer JT, Saldanha L, Bailey RL, Merkel J, Wambogo E. Costello RB, et al. J Acad Nutr Diet. 2016 Nov;116(11):1794-1802. doi: 10.1016/j.jand.2016.07.015. Epub 2016 Sep 8. J Acad Nutr Diet. 2016. PMID: 27618575 Free PMC article. Review.
Cinnamon (Cinnamomum sp) has been suggested to help patients with type 2 diabetes mellitus (T2DM) achieve better glycemic control, although conclusions from meta-analyses are mixed. ...The species of cinnamon used varied: seven used Cinnamomum cassia or Cinnamomu …
Cinnamon (Cinnamomum sp) has been suggested to help patients with type 2 diabetes mellitus (T2DM) achieve better glycemic control, al …
Cinnamon Infusion Reduces Satiety and Increases Energy Intake: A Randomized Crossover Trial.
Soares APDC, de Faria NC, Graciano GF, Dos Santos ALS, Valenzuela VDC, Toulson Davisson Correia MI, Cosenza GP, Anastácio LR. Soares APDC, et al. Ann Nutr Metab. 2022;78(5):265-272. doi: 10.1159/000525949. Epub 2022 Jul 13. Ann Nutr Metab. 2022. PMID: 35830848 Clinical Trial.
METHODS: This was an open randomized crossover clinical trial, with a minimum washout of 7 days, in which two standardized breakfasts were served randomly: one with cinnamon infusion (2 g, Cinnamomum sp.) and one with water (control). ...
METHODS: This was an open randomized crossover clinical trial, with a minimum washout of 7 days, in which two standardized bre …
A comparison of the effects of cinnamon, ginger, and metformin consumption on metabolic health, anthropometric indices, and sexual hormone levels in women with poly cystic ovary syndrome: A randomized double-blinded placebo-controlled clinical trial.
Dastgheib M, Barati-Boldaji R, Bahrampour N, Taheri R, Borghei M, Amooee S, Mohammadi-Sartang M, Wong A, Babajafari S, Mazloomi SM. Dastgheib M, et al. Front Nutr. 2022 Nov 29;9:1071515. doi: 10.3389/fnut.2022.1071515. eCollection 2022. Front Nutr. 2022. PMID: 36523331 Free PMC article.
Overall, cinnamon and ginger supplementations may potentially be used as alternative treatment in women with PCOS. CLINICAL TRIAL REGISTRATION: [https://www.irct.ir/trial/28548], identifier [IRCT20171227038105N1]....
Overall, cinnamon and ginger supplementations may potentially be used as alternative treatment in women with PCOS. CLINICAL TRIAL …
Potential of Cinnamomum zeylanicum for metabolic syndrome management: insights from in vivo and human studies.
Adarthaiya S, Arivarasan VK. Adarthaiya S, et al. J Integr Med. 2025 May;23(3):218-229. doi: 10.1016/j.joim.2025.04.005. Epub 2025 Apr 22. J Integr Med. 2025. PMID: 40319007 Review.
One such alternative relies on the potential of spices and condiments, which have a long history of use in traditional medicine. Among them, Cinnamomum zeylanicum Blume stands out as a popular spice worldwide for its unique taste, aroma, and delicate sweetness compa …
One such alternative relies on the potential of spices and condiments, which have a long history of use in traditional medicine. Among them, …
Cinnamon in glycaemic control: Systematic review and meta analysis.
Akilen R, Tsiami A, Devendra D, Robinson N. Akilen R, et al. Clin Nutr. 2012 Oct;31(5):609-15. doi: 10.1016/j.clnu.2012.04.003. Epub 2012 May 12. Clin Nutr. 2012. PMID: 22579946
Search terms included free text terms, MeSH and Medline medical index terms such as: "cinnamon", "cinnamomum", "cinnamomum cassia", "cinnamomum zeylanicum", "type 2 diabetes mellitus". Each was crossed with the term "diabetes mellitus". ...
Search terms included free text terms, MeSH and Medline medical index terms such as: "cinnamon", "cinnamomum", "cinnamomum cas …
Effect of milled flaxseed and storage conditions on sensory properties and selected bioactive compounds in banana and cinnamon muffins used in a clinical trial.
Santiago A, Ryland D, Cui S, Blewett H, Aliani M. Santiago A, et al. J Sci Food Agric. 2019 Jan 30;99(2):831-843. doi: 10.1002/jsfa.9253. Epub 2018 Aug 29. J Sci Food Agric. 2019. PMID: 29999194 Clinical Trial.
The effect of milled flaxseed and storage (-20 C for 1 and 6 months) of banana and cinnamon muffins on sensory attribute intensities, selected physical properties, bioactive concentrations, and acceptability by two groups - clinical trial participants and consumers …
The effect of milled flaxseed and storage (-20 C for 1 and 6 months) of banana and cinnamon muffins on sensory attribute intensities, selec …
Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial.
de Araújo MRC, Maciel PP, Castellano LRC, Bonan PRF, Alves DDN, de Medeiros ACD, de Castro RD. de Araújo MRC, et al. Spec Care Dentist. 2021 May;41(3):349-357. doi: 10.1111/scd.12570. Epub 2021 Jan 21. Spec Care Dentist. 2021. PMID: 33475184 Clinical Trial.
AIM: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis. METHODS AND RESULTS: A randomized, controlled, and blinded clinical trial was conducted with 36 …
AIM: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the …
Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial.
Davari M, Hashemi R, Mirmiran P, Hedayati M, Sahranavard S, Bahreini S, Tavakoly R, Talaei B. Davari M, et al. Nutr J. 2020 Jan 4;19(1):1. doi: 10.1186/s12937-019-0518-3. Nutr J. 2020. PMID: 31901246 Free PMC article. Clinical Trial.
SUBJECTS AND METHODS: A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were 25 to 70 years old with type 2 diabetes, randomized to two intervention (n = 22) and control (n = 22) groups differing by daily three grams …
SUBJECTS AND METHODS: A randomized, double blind, and controlled clinical trial was performed with 44 adult patients who were …
Cassia cinnamon for the attenuation of glucose intolerance and insulin resistance resulting from sleep loss.
Jitomir J, Willoughby DS. Jitomir J, et al. J Med Food. 2009 Jun;12(3):467-72. doi: 10.1089/jmf.2008.0128. J Med Food. 2009. PMID: 19627193 Review.
An increasing body of scientific evidence indicates that acute sleep loss induces insulin resistance and glucose intolerance profiles similar to those of type 2 diabetes mellitus patients. Experimentally, cassia cinnamon (Cinnamomum cassia) supplementation facilitates gluc …
An increasing body of scientific evidence indicates that acute sleep loss induces insulin resistance and glucose intolerance profiles simila …
Evaluation of the Effectiveness of Cinnamon Oil Soft Capsule in Patients with Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Clinical Trial.
Zobeiri M, Parvizi F, Shahpiri Z, Heydarpour F, Pourfarzam M, Memarzadeh MR, Rahimi R, Farzaei MH. Zobeiri M, et al. Evid Based Complement Alternat Med. 2021 May 13;2021:6634115. doi: 10.1155/2021/6634115. eCollection 2021. Evid Based Complement Alternat Med. 2021. PMID: 34093719 Free PMC article.
The aim of this study is to evaluate the efficacy and safety of cinnamon oil (Cinnamomum zeylanicum) in patients with functional dyspepsia in a double-blind, randomized placebo-controlled trial. ...
The aim of this study is to evaluate the efficacy and safety of cinnamon oil (Cinnamomum zeylanicum) in patients with function …
Effect of cinnamon (Cinnamomum Zeylanicum) supplementation on serum C-reactive protein concentrations: A meta-analysis and systematic review.
Vallianou N, Tsang C, Taghizadeh M, Davoodvandi A, Jafarnejad S. Vallianou N, et al. Complement Ther Med. 2019 Feb;42:271-278. doi: 10.1016/j.ctim.2018.12.005. Epub 2018 Dec 7. Complement Ther Med. 2019. PMID: 30670254 Free article.
OBJECTIVE: The effect of cinnamon (Cinnamomum Zeylanicum) on serum C-reactive protein (CRP), an acute phase protein commonly used as a marker of inflammation, is uncertain. ...
OBJECTIVE: The effect of cinnamon (Cinnamomum Zeylanicum) on serum C-reactive protein (CRP), an acute phase protein commonly u …
Safety and Tolerability of Essential Oil from Cinnamomum zeylanicum Blume Leaves with Action on Oral Candidosis and Its Effect on the Physical Properties of the Acrylic Resin.
Oliveira Jde A, da Silva IC, Trindade LA, Lima EO, Carlo HL, Cavalcanti AL, de Castro RD. Oliveira Jde A, et al. Evid Based Complement Alternat Med. 2014;2014:325670. doi: 10.1155/2014/325670. Epub 2014 Dec 9. Evid Based Complement Alternat Med. 2014. PMID: 25574178 Free PMC article.
The anti-Candida activity of essential oil from Cinnamomum zeylanicum Blume, as well as its effect on the roughness and hardness of the acrylic resin used in dental prostheses, was assessed. ...For the phase I clinical trial, 15 healthy patients used s …
The anti-Candida activity of essential oil from Cinnamomum zeylanicum Blume, as well as its effect on the roughness and hardne …
Insulin resistance improvement by cinnamon powder in polycystic ovary syndrome: A randomized double-blind placebo controlled clinical trial.
Hajimonfarednejad M, Nimrouzi M, Heydari M, Zarshenas MM, Raee MJ, Jahromi BN. Hajimonfarednejad M, et al. Phytother Res. 2018 Feb;32(2):276-283. doi: 10.1002/ptr.5970. Epub 2017 Dec 18. Phytother Res. 2018. PMID: 29250843 Clinical Trial.
Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double-blind placebo-controlled clinical trial. All of the PCOS women were taking medroxy progesterone acetate 10 mg/day for the last 10 days of their menstrual cy …
Out of 80 women that were diagnosed as PCOS by Rotterdam Criteria, 66 were enrolled in this randomized double-blind placebo-controlled cl …
Analysis of Unani coded formulation on the hormonal parameters of patients with polycystic ovarian syndrome.
Hameed L, Farooq AD, Qureshi T. Hameed L, et al. Pak J Pharm Sci. 2021 May;34(3):899-907. Pak J Pharm Sci. 2021. PMID: 34602412 Clinical Trial.
The effect of Unani coded polyherbal formulations (Picolin) containing: 1) Cinnamomum verum (Bark), 2) Glycyrrhiza glabra (Root), 3) Linum usitatissimum (Seed) and 4) Vitex agnus castus (Seed) on the hormonal levels of polycystic ovarian syndrome (PCOS) patients (n= …
The effect of Unani coded polyherbal formulations (Picolin) containing: 1) Cinnamomum verum (Bark), 2) Glycyrrhiza glabra (Roo …
Acute effect of Ceylon cinnamon extract on postprandial glycemia: alpha-amylase inhibition, starch tolerance test in rats, and randomized crossover clinical trial in healthy volunteers.
Beejmohun V, Peytavy-Izard M, Mignon C, Muscente-Paque D, Deplanque X, Ripoll C, Chapal N. Beejmohun V, et al. BMC Complement Altern Med. 2014 Sep 23;14:351. doi: 10.1186/1472-6882-14-351. BMC Complement Altern Med. 2014. PMID: 25249234 Free PMC article. Clinical Trial.
Then, a randomized, double-blind, placebo-controlled, cross-over clinical trial was conducted in 18 healthy female and male volunteers. Following the intake of 1 g of CCE, the subjects ate a standardized meal. ...In both, the in vitro and in vivo studies, the hydro- …
Then, a randomized, double-blind, placebo-controlled, cross-over clinical trial was conducted in 18 healthy female and male vo …
Controlling type 2 diabetes mellitus with herbal medicines: A triple-blind randomized clinical trial of efficacy and safety.
Mirfeizi M, Mehdizadeh Tourzani Z, Mirfeizi SZ, Asghari Jafarabadi M, Rezvani HR, Afzali M. Mirfeizi M, et al. J Diabetes. 2016 Sep;8(5):647-56. doi: 10.1111/1753-0407.12342. Epub 2015 Dec 1. J Diabetes. 2016. PMID: 26362826 Clinical Trial.
METHODS: In all, 105 T2DM patients were recruited to the present randomized triple-blinded clinical trial. Patients were randomly divided into three groups and administered either placebo, cinnamon or whortleberry supplements (1 g/day) for 90 days. ...
METHODS: In all, 105 T2DM patients were recruited to the present randomized triple-blinded clinical trial. Patients were rando …
Effect of cinnamon, cardamom, saffron and ginger consumption on blood pressure and a marker of endothelial function in patients with type 2 diabetes mellitus: A randomized controlled clinical trial.
Azimi P, Ghiasvand R, Feizi A, Hosseinzadeh J, Bahreynian M, Hariri M, Khosravi-Boroujeni H. Azimi P, et al. Blood Press. 2016 Jun;25(3):133-40. doi: 10.3109/08037051.2015.1111020. Epub 2016 Jan 12. Blood Press. 2016. PMID: 26758574 Free article. Clinical Trial.
This study aimed to determine the effect of herbal treatment on BP, endothelial function and anthropometric measures in patients with type 2 diabetes mellitus (T2DM). This clinical trial included 204 T2DM patients randomly assigned to four intervention groups receiv …
This study aimed to determine the effect of herbal treatment on BP, endothelial function and anthropometric measures in patients with type 2 …
Cinnamon improves metabolic factors without detectable effects on adiponectin in women with polycystic ovary syndrome.
Borzoei A, Rafraf M, Asghari-Jafarabadi M. Borzoei A, et al. Asia Pac J Clin Nutr. 2018;27(3):556-563. doi: 10.6133/apjcn.062017.13. Asia Pac J Clin Nutr. 2018. PMID: 29737802 Free article. Clinical Trial.
METHODS AND STUDY DESIGN: This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS patients. Subjects in cinnamon (n=42) and placebo (n=42) groups were given 3 cinnamon capsules (each one contained 500 mg cinnamon) or place …
METHODS AND STUDY DESIGN: This double-blind randomized controlled clinical trial was conducted on 84 overweight or obese PCOS …
Efficacy of cinnamon patch treatment for alleviating symptoms of overactive bladder: A double-blind, randomized, placebo-controlled trial.
Chen LL, Shen YC, Ke CC, Imtiyaz Z, Chen HI, Chang CH, Lee MH. Chen LL, et al. Phytomedicine. 2021 Jan;80:153380. doi: 10.1016/j.phymed.2020.153380. Epub 2020 Oct 12. Phytomedicine. 2021. PMID: 33091856 Clinical Trial.
MATERIALS AND METHODS: In this 6-week randomized clinical trial conducted in an outpatient setting, 66 subjects diagnosed as having OAB were enrolled and treated with a placebo (n=33) or CP (n=33). ...
MATERIALS AND METHODS: In this 6-week randomized clinical trial conducted in an outpatient setting, 66 subjects diagnosed as h …
Effects of Cinnamon Consumption on Glycemic Indicators, Advanced Glycation End Products, and Antioxidant Status in Type 2 Diabetic Patients.
Talaei B, Amouzegar A, Sahranavard S, Hedayati M, Mirmiran P, Azizi F. Talaei B, et al. Nutrients. 2017 Sep 8;9(9):991. doi: 10.3390/nu9090991. Nutrients. 2017. PMID: 28885566 Free PMC article. Clinical Trial.
In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 8 years, were randomly assigned to take either a three g/day cinnamon supplement (n = 22) or a placebo (n = 22) for eight weeks. ...
In a double-blind, randomized, placebo controlled clinical trial study, 44 patients with type 2 diabetes, aged 57 8 years, w …
Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes Patients.
Azimi P, Ghiasvand R, Feizi A, Hariri M, Abbasi B. Azimi P, et al. Rev Diabet Stud. 2014 Fall-Winter;11(3-4):258-66. doi: 10.1900/RDS.2014.11.258. Epub 2015 Feb 10. Rev Diabet Stud. 2014. PMID: 26177486 Free PMC article.
The aim of the present study was to determine the effects of cinnamon, cardamom, saffron, and ginger as supplementary remedies in T2D. METHODS: This randomized controlled, clinical trial included 204 T2D patients. The participants were randomly assigned to four inte …
The aim of the present study was to determine the effects of cinnamon, cardamom, saffron, and ginger as supplementary remedies in T2D. METHO …
Effectiveness of a Food Supplement Based on Glucomannan, D-Chiro-Inositol, Cinnamomum zeylanicum Blume and Inulin in Patients with Metabolic Syndrome.
Citarrella R, Chianetta R, Amodeo S, Mirarchi L, Licata A, Soresi M, Veronese N, Barbagallo M, Giannitrapani L. Citarrella R, et al. Nutrients. 2024 Jan 12;16(2):249. doi: 10.3390/nu16020249. Nutrients. 2024. PMID: 38257142 Free PMC article. Clinical Trial.
Fifty-eight subjects with MetS and T2DM or impaired glucose tolerance assuming metformin, were randomly assigned to take a food supplement of glucomannan, D-chiro-inositol, Cinnamomum zeylanicum blume and inulin at a daily fixed dose of 4 g orally for four months. . …
Fifty-eight subjects with MetS and T2DM or impaired glucose tolerance assuming metformin, were randomly assigned to take a food supplement o …
A randomized, double-blind placebo-controlled study of intranasal standardized cinnamon bark extract for seasonal allergic rhinitis.
Steels E, Steels E, Deshpande P, Thakurdesai P, Dighe S, Collet T. Steels E, et al. Complement Ther Med. 2019 Dec;47:102198. doi: 10.1016/j.ctim.2019.102198. Epub 2019 Sep 24. Complement Ther Med. 2019. PMID: 31780001 Clinical Trial.
OBJECTIVES: The aim of the study was to assess the safety and efficacy of a nasal spray containing a polyphenol-rich standardized extract of cinnamon bark (Cinnamomum zeylanicum) (IND02) for the treatment of seasonal allergic rhinitis (SAR). METHODS: This study was …
OBJECTIVES: The aim of the study was to assess the safety and efficacy of a nasal spray containing a polyphenol-rich standardized extract of …
Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial.
Corren J, Lemay M, Lin Y, Rozga L, Randolph RK. Corren J, et al. Nutr J. 2008 Jul 14;7:20. doi: 10.1186/1475-2891-7-20. Nutr J. 2008. PMID: 18625073 Free PMC article. Clinical Trial.
BACKGROUND: Botanical products are frequently used for treatment of nasal allergy. Three of these substances, Cinnamomum zeylanicum, Malpighia glabra, and Bidens pilosa, have been shown to have a number of anti-allergic properties in-vitro. ...
BACKGROUND: Botanical products are frequently used for treatment of nasal allergy. Three of these substances, Cinnamomum zeylanicu …
Enhanced antibiofilm and gene-suppressive effects of cinnamon nanoemulsion against multidrug-resistant Enterococcus faecalis.
Gholizadeh P, Rahimzadeh R, Mohammadi-Ghalehbin B, Arzanlou M, Soozangar N, Feizi H. Gholizadeh P, et al. Mol Biol Rep. 2026 Feb 24;53(1):419. doi: 10.1007/s11033-026-11590-8. Mol Biol Rep. 2026. PMID: 41733704
BACKGROUND: Enterococcus faecalis is a major cause of persistent endodontic infections due to its strong biofilm-forming ability and resistance to conventional disinfectants. Cinnamon (Cinnamomum zeylanicum) essential oil (EO) has been recognized for its antimicrobi …
BACKGROUND: Enterococcus faecalis is a major cause of persistent endodontic infections due to its strong biofilm-forming ability and resista …
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