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A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. Boström P, et al. Among authors: Cinti S. Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038/nature10777. Nature. 2012. PMID: 22237023 Free PMC article.
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Haemmerle G, Moustafa T, Woelkart G, Büttner S, Schmidt A, van de Weijer T, Hesselink M, Jaeger D, Kienesberger PC, Zierler K, Schreiber R, Eichmann T, Kolb D, Kotzbeck P, Schweiger M, Kumari M, Eder S, Schoiswohl G, Wongsiriroj N, Pollak NM, Radner FP, Preiss-Landl K, Kolbe T, Rülicke T, Pieske B, Trauner M, Lass A, Zimmermann R, Hoefler G, Cinti S, Kershaw EE, Schrauwen P, Madeo F, Mayer B, Zechner R. Haemmerle G, et al. Among authors: Cinti S. Nat Med. 2011 Aug 21;17(9):1076-85. doi: 10.1038/nm.2439. Nat Med. 2011. PMID: 21857651 Free PMC article.
Here we show that lipolysis of cellular triglycerides by adipose triglyceride lipase (patatin-like phospholipase domain containing protein 2, encoded by Pnpla2; hereafter referred to as Atgl) generates essential mediator(s) involved in the generation of lipid ligands for PPAR activation. ...
Here we show that lipolysis of cellular triglycerides by adipose triglyceride lipase (patatin-like phospholipase domain containing protein 2 …
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance.
Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Vianna CR, et al. Among authors: Cinti S. Cell Metab. 2006 Dec;4(6):453-64. doi: 10.1016/j.cmet.2006.11.003. Cell Metab. 2006. PMID: 17141629 Free PMC article.
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Lin J, et al. Among authors: Cinti S. Cell. 2004 Oct 1;119(1):121-35. doi: 10.1016/j.cell.2004.09.013. Cell. 2004. PMID: 15454086
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.
Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, Spiegelman BM. Arany Z, et al. Among authors: Cinti S. Cell Metab. 2005 Apr;1(4):259-71. doi: 10.1016/j.cmet.2005.03.002. Cell Metab. 2005. PMID: 16054070
Neuronal protein tyrosine phosphatase 1B deficiency results in inhibition of hypothalamic AMPK and isoform-specific activation of AMPK in peripheral tissues.
Xue B, Pulinilkunnil T, Murano I, Bence KK, He H, Minokoshi Y, Asakura K, Lee A, Haj F, Furukawa N, Catalano KJ, Delibegovic M, Balschi JA, Cinti S, Neel BG, Kahn BB. Xue B, et al. Among authors: Cinti S. Mol Cell Biol. 2009 Aug;29(16):4563-73. doi: 10.1128/MCB.01914-08. Epub 2009 Jun 15. Mol Cell Biol. 2009. PMID: 19528236 Free PMC article.
AMPK is an important mediator of leptin's metabolic effects. We find that alpha1 and alpha2 AMPK activity are elevated and acetyl-coenzyme A carboxylase activity is decreased in the muscle and brown adipose tissue (BAT) of PTP1B(-/-) mice. ...
AMPK is an important mediator of leptin's metabolic effects. We find that alpha1 and alpha2 AMPK activity are elevated and acetyl-coe …
betaAR signaling required for diet-induced thermogenesis and obesity resistance.
Bachman ES, Dhillon H, Zhang CY, Cinti S, Bianco AC, Kobilka BK, Lowell BB. Bachman ES, et al. Among authors: Cinti S. Science. 2002 Aug 2;297(5582):843-5. doi: 10.1126/science.1073160. Science. 2002. PMID: 12161655
These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in the body's defense against diet-induced obesity....
These findings establish that betaARs are necessary for diet-induced thermogenesis and that this efferent pathway plays a critical role in t …
Brown and white adipose tissues: intrinsic differences in gene expression and response to cold exposure in mice.
Rosell M, Kaforou M, Frontini A, Okolo A, Chan YW, Nikolopoulou E, Millership S, Fenech ME, MacIntyre D, Turner JO, Moore JD, Blackburn E, Gullick WJ, Cinti S, Montana G, Parker MG, Christian M. Rosell M, et al. Among authors: Cinti S. Am J Physiol Endocrinol Metab. 2014 Apr 15;306(8):E945-64. doi: 10.1152/ajpendo.00473.2013. Epub 2014 Feb 18. Am J Physiol Endocrinol Metab. 2014. PMID: 24549398 Free PMC article.
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