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Determining γδ versus αß T cell development.
Ciofani M, Zúñiga-Pflücker JC. Ciofani M, et al. Nat Rev Immunol. 2010 Sep;10(9):657-63. doi: 10.1038/nri2820. Epub 2010 Aug 20. Nat Rev Immunol. 2010. PMID: 20725107 Review.
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
Ciofani M, Zúñiga-Pflücker JC. Ciofani M, et al. Nat Immunol. 2005 Sep;6(9):881-8. doi: 10.1038/ni1234. Epub 2005 Jul 31. Nat Immunol. 2005. PMID: 16056227
A survival guide to early T cell development.
Ciofani M, Zúñiga-Pflücker JC. Ciofani M, et al. Immunol Res. 2006;34(2):117-32. doi: 10.1385/IR:34:2:117. Immunol Res. 2006. PMID: 16760572 Review.
The thymus as an inductive site for T lymphopoiesis.
Ciofani M, Zúñiga-Pflücker JC. Ciofani M, et al. Annu Rev Cell Dev Biol. 2007;23:463-93. doi: 10.1146/annurev.cellbio.23.090506.123547. Annu Rev Cell Dev Biol. 2007. PMID: 17506693 Review.
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zúñiga-Pflücker JC, Dominguez M, Ferrando AA. Palomero T, et al. Among authors: ciofani m. Nat Med. 2007 Oct;13(10):1203-10. doi: 10.1038/nm1636. Epub 2007 Sep 16. Nat Med. 2007. PMID: 17873882 Free PMC article.
Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.
Michie AM, Chan AC, Ciofani M, Carleton M, Lefebvre JM, He Y, Allman DM, Wiest DL, Zúñiga-Pflücker JC, Izon DJ. Michie AM, et al. Among authors: ciofani m. Int Immunol. 2007 Dec;19(12):1421-30. doi: 10.1093/intimm/dxm113. Epub 2007 Nov 1. Int Immunol. 2007. PMID: 17981791
Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent.
Lauritsen JP, Wong GW, Lee SY, Lefebvre JM, Ciofani M, Rhodes M, Kappes DJ, Zúñiga-Pflücker JC, Wiest DL. Lauritsen JP, et al. Among authors: ciofani m. Immunity. 2009 Oct 16;31(4):565-75. doi: 10.1016/j.immuni.2009.07.010. Immunity. 2009. PMID: 19833086 Free PMC article.
Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells.
Chong MM, Simpson N, Ciofani M, Chen G, Collins A, Littman DR. Chong MM, et al. Among authors: ciofani m. Genes Dev. 2010 Apr 1;24(7):659-69. doi: 10.1101/gad.1901610. Genes Dev. 2010. PMID: 20360383 Free PMC article.
Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity.
Huh JR, Leung MW, Huang P, Ryan DA, Krout MR, Malapaka RR, Chow J, Manel N, Ciofani M, Kim SV, Cuesta A, Santori FR, Lafaille JJ, Xu HE, Gin DY, Rastinejad F, Littman DR. Huh JR, et al. Among authors: ciofani m. Nature. 2011 Apr 28;472(7344):486-90. doi: 10.1038/nature09978. Epub 2011 Mar 27. Nature. 2011. PMID: 21441909 Free PMC article.
Dynamic microRNA gene transcription and processing during T cell development.
Kirigin FF, Lindstedt K, Sellars M, Ciofani M, Low SL, Jones L, Bell F, Pauli F, Bonneau R, Myers RM, Littman DR, Chong MM. Kirigin FF, et al. Among authors: ciofani m. J Immunol. 2012 Apr 1;188(7):3257-67. doi: 10.4049/jimmunol.1103175. Epub 2012 Feb 29. J Immunol. 2012. PMID: 22379031 Free PMC article.
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