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Cardio-Immuno-Oncology
Zaha VG, et al. Circulation 2020. PMID 31928434
Identification of Circulating Proteins Associated with Blood Pressure Using Mendelian Randomization
Thériault S, et al. Circ Genom Precis Med 2020. PMID 31928076
MR analyses with cardiovascular risk factors and outcomes as well as other biomarkers were performed to further evaluate the mechanisms involved. ...Further MR analyses with cardiovascular risk factors and outcomes showed relationships between NT-proBNP and large-artery atherosclerotic stroke, IGFBP3 and diabetes as well as cFn and body-mass index. ...
MR analyses with cardiovascular risk factors and outcomes as well as other biomarkers were performed to further evaluate the mechanisms involved. ...Further MR analyses with cardiovascular risk factors and outcomes showed relationships between NT-proBNP and large-artery atherosclerotic …
Deep Mutational Scan of an SCN5A Voltage Sensor
Glazer AM, et al. Circ Genom Precis Med 2020. PMID 31928070
Methods - We have developed and validated a method to perform a DMS of variants in SCN5A, which encodes the major voltage-gated sodium channel in the heart. ...
Methods - We have developed and validated a method to perform a DMS of variants in SCN5A, which encodes the major voltage-gated sodium channel in the heart. ...
Epigenome-wide Association Study Identifies a Novel DNA Methylation in Patients with Severe Aortic Valve Stenosis
Nasu T, et al. Circ Genom Precis Med 2020. PMID 31928219
Aortic valve stenosis (AS) is the most common valvular heart disease in the aging population, and it is associated with significant morbidity and mortality. ...
Aortic valve stenosis (AS) is the most common valvular heart disease in the aging population, and it is associated with significant morbidity and mortality. ...
Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome
Kim AJ, et al. Circulation 2020. PMID 31928435
BACKGROUND: Myxomatous valve degeneration (MVD) involves the progressive thickening and degeneration of the heart valves, leading to valve prolapse, regurgitant blood flow, and impaired cardiac function. ...
BACKGROUND: Myxomatous valve degeneration (MVD) involves the progressive thickening and degeneration of the heart valves, leading to valve prolapse, regurgitant blood flow, and impaired cardiac function. ...
Genetically Determined High Levels of Iron Parameters Are Protective for Coronary Artery Disease
Grote Beverborg N, et al. Circ Genom Precis Med 2020. PMID 31928077
The observation that premenopausal women have a relatively low incidence of heart disease led in the nineteen eighties to the hypothesis that iron deficiency protects against heart diseases. ...
The observation that premenopausal women have a relatively low incidence of heart disease led in the nineteen eighties to the hypothesis that iron deficiency protects against heart diseases. ...
The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials
Neelakantan N, et al. Circulation 2020. PMID 31928080
The main outcomes included low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), total cholesterol, triglycerides, measures of body fatness, markers of inflammation, and glycemia. ...
The main outcomes included low-density lipoprotein cholesterol (LDL-cholesterol), high-density lipoprotein cholesterol (HDL-cholesterol), total cholesterol, triglycerides, measures of body fatness, markers of inflammation, and glycemia. ...
Prospective CYP2C19 Genotyping to Guide Antiplatelet Therapy Following Percutaneous Coronary Intervention: A Pragmatic Randomized Clinical Trial
Tuteja S, et al. Circ Genom Precis Med 2020. PMID 31928229
Secondary outcomes included agreement to the genotype guided recommendations. Methods - At the time of PCI, participants were randomly assigned to prospective rapid point-of-care genotyping of CYP2C19 major alleles (*2, *3, *17) via salivary swab (genotyped group) or no genotyping (usual care) to guide antiplatelet drug selection. ...
Secondary outcomes included agreement to the genotype guided recommendations. Methods - At the time of PCI, participants were randomly assigned to prospective rapid point-of-care genotyping of CYP2C19 major alleles (*2, *3, *17) via salivary swab (genotyped group) or no genotyping (usual care …
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