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Page 1
The Emerging Importance of Cirsimaritin in Type 2 Diabetes Treatment.
Alqudah A, Athamneh RY, Qnais E, Gammoh O, Oqal M, AbuDalo R, Alshaikh HA, Al-Hashimi N, Alqudah M. Alqudah A, et al. Int J Mol Sci. 2023 Mar 17;24(6):5749. doi: 10.3390/ijms24065749. Int J Mol Sci. 2023. PMID: 36982822 Free PMC article.
Cirsimaritin was able to upregulate GLUT2 and AMPK protein expression in the liver (p < 0.01, <0.05, respectively). ...Cirsimaritin could represent a promising therapeutic agent to treat T2D....
Cirsimaritin was able to upregulate GLUT2 and AMPK protein expression in the liver (p < 0.01, <0.05, respectively). ...Cirsi …
The Current State of Knowledge in Biological Properties of Cirsimaritin.
Benali T, Jaouadi I, Ghchime R, El Omari N, Harboul K, Hammani K, Rebezov M, Shariati MA, Mubarak MS, Simal-Gandara J, Zengin G, Park MN, Kim B, Mahmud S, Lee LH, Bouyahya A. Benali T, et al. Antioxidants (Basel). 2022 Sep 19;11(9):1842. doi: 10.3390/antiox11091842. Antioxidants (Basel). 2022. PMID: 36139916 Free PMC article. Review.
The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation of this flavonoid from various natural sources, including medicinal plants such as Artemisia judaica, Cirsium japonicum, Lithocarpus dealbat …
The objective of this study is to review the source and pharmacological properties of cirsimaritin. The identification and isolation …
Anti-inflammatory effects and corresponding mechanisms of cirsimaritin extracted from Cirsium japonicum var. maackii Maxim.
Shin MS, Park JY, Lee J, Yoo HH, Hahm DH, Lee SC, Lee S, Hwang GS, Jung K, Kang KS. Shin MS, et al. Bioorg Med Chem Lett. 2017 Jul 15;27(14):3076-3080. doi: 10.1016/j.bmcl.2017.05.051. Epub 2017 May 17. Bioorg Med Chem Lett. 2017. PMID: 28554870
The extract and its flavonoid cirsimaritin inhibited nitric oxide (NO) production and inducible nitric oxide synthase expression in RAW264.7 cells. ...From a western blot study, pretreatment with cirsimaritin inhibited phosphorylation/degradation of IkappaBalpha and …
The extract and its flavonoid cirsimaritin inhibited nitric oxide (NO) production and inducible nitric oxide synthase expression in R …
Cirsimaritin, a lung squamous carcinoma cells (NCIH-520) proliferation inhibitor.
Pathak G, Singh S, Kumari P, Raza W, Hussain Y, Meena A. Pathak G, et al. J Biomol Struct Dyn. 2021 Jun;39(9):3312-3323. doi: 10.1080/07391102.2020.1763198. Epub 2020 May 13. J Biomol Struct Dyn. 2021. PMID: 32362196
Cirsimaritin is a dimethoxy flavone, which is present in Ocimum sanctum, Microtea debilis, Artemisia judaica, Cirsium japonicum, and Lithocarpus dealbatus. ...Therefore, in the present study, the anticancer potential of cirsimaritin is explored in organ-specific cel …
Cirsimaritin is a dimethoxy flavone, which is present in Ocimum sanctum, Microtea debilis, Artemisia judaica, Cirsium japonicum, and …
Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives.
Su L, Li W, Liu K, Wang Q. Su L, et al. Nat Prod Res. 2022 Aug;36(16):4070-4075. doi: 10.1080/14786419.2021.1961136. Epub 2021 Aug 5. Nat Prod Res. 2022. PMID: 34353180
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4'-hydroxyflavone (1a), 5,6,7,3',4' -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3',4'-methyl enedioxy flavone (1c), 5,6,7,3'-tetram …
A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4'-h …
Protective effect of cirsimaritin against streptozotocin-induced apoptosis in pancreatic beta cells.
Lee D, Kim KH, Lee J, Hwang GS, Lee HL, Hahm DH, Huh CK, Lee SC, Lee S, Kang KS. Lee D, et al. J Pharm Pharmacol. 2017 Jul;69(7):875-883. doi: 10.1111/jphp.12719. Epub 2017 Apr 11. J Pharm Pharmacol. 2017. PMID: 28397263
In addition, cirsimaritin reduced the intracellular oxidative stress induced by STZ. ...CONCLUSIONS: This study demonstrates the therapeutic potential and action mechanism of cirsimaritin for the prevention and treatment of type 1 diabetes mellitus....
In addition, cirsimaritin reduced the intracellular oxidative stress induced by STZ. ...CONCLUSIONS: This study demonstrates the ther …
Cirsimarin and cirsimaritin, flavonoids of Microtea debilis (Phytolaccaceae) with adenosine antagonistic properties in rats: leads for new therapeutics in acute renal failure.
Hasrat JA, De Bruyne T, De Backer JP, Vauquelin G, Vlietinck AJ. Hasrat JA, et al. J Pharm Pharmacol. 1997 Nov;49(11):1150-6. doi: 10.1111/j.2042-7158.1997.tb06059.x. J Pharm Pharmacol. 1997. PMID: 9401955
After oral administration of 8 and 80 mg kg-1 cirsimarin, the compound could not be detected in either plasma or urine, but the presence of cirsimaritin was established. By use of beta-glucuronidase, glucuronides of cirsimaritin were also detected in the urine. ...T …
After oral administration of 8 and 80 mg kg-1 cirsimarin, the compound could not be detected in either plasma or urine, but the presence of …
Ameliorative effects of Cirsium japonicum extract and main component cirsimaritin in mice model of high-fat diet-induced metabolic dysfunction-associated fatty liver disease.
Che DN, Shin JY, Kang HJ, Cho BO, Park JH, Wang F, Hao S, Sim JS, Sim DJ, Jang SI. Che DN, et al. Food Sci Nutr. 2021 Sep 1;9(11):6060-6068. doi: 10.1002/fsn3.2548. eCollection 2021 Nov. Food Sci Nutr. 2021. PMID: 34760237 Free PMC article.
These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic steatosis to fibrosis and cirrhosis. Our study suggests that CJE and cirsimaritin might be promising agents for preventing and/or tre …
These results demonstrate that CJE and cirsimaritin as its main compound have a preventive action against the progression of hepatic …
Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.
Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY. Kim HJ, et al. Int J Mol Sci. 2015 Apr 20;16(4):8772-88. doi: 10.3390/ijms16048772. Int J Mol Sci. 2015. PMID: 25903150 Free PMC article.
The melanin-inducing properties of cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone with methoxy groups, which is isolated from the branches of Lithocarpus dealbatus. ...Finally, the melanogenic effect of cirsimaritin w …
The melanin-inducing properties of cirsimaritin were investigated in murine B16F10 cells. Cirsimaritin is an active flavone wi …
Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells.
Yeon Park J, Young Kim H, Shibamoto T, Su Jang T, Cheon Lee S, Suk Shim J, Hahm DH, Lee HJ, Lee S, Sung Kang K. Yeon Park J, et al. Bioorg Med Chem Lett. 2017 Sep 1;27(17):3968-3973. doi: 10.1016/j.bmcl.2017.07.070. Epub 2017 Jul 29. Bioorg Med Chem Lett. 2017. PMID: 28784292
The inhibition achieved was 36.89% at a level of 200mug/ml by the ICF-1 extract and 62.04% at a level of 100muM by cirsimaritin. The ICF-1 extract and cirsimaritin reduced tube formation by 12.69% at level of 25mug/ml and 32.18% at the levels of 6.25muM, respectivel …
The inhibition achieved was 36.89% at a level of 200mug/ml by the ICF-1 extract and 62.04% at a level of 100muM by cirsimaritin. The …
120 results