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The p66Shc knocked out mice are short lived under natural condition.
Giorgio M, Berry A, Berniakovich I, Poletaeva I, Trinei M, Stendardo M, Hagopian K, Ramsey JJ, Cortopassi G, Migliaccio E, Nötzli S, Amrein I, Lipp HP, Cirulli F, Pelicci PG. Giorgio M, et al. Among authors: cirulli f. Aging Cell. 2012 Feb;11(1):162-8. doi: 10.1111/j.1474-9726.2011.00770.x. Epub 2011 Dec 28. Aging Cell. 2012. PMID: 22081964 Free article.
Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.
Berry A, Greco A, Giorgio M, Pelicci PG, de Kloet R, Alleva E, Minghetti L, Cirulli F. Berry A, et al. Among authors: cirulli f. Exp Gerontol. 2008 Mar;43(3):200-8. doi: 10.1016/j.exger.2007.10.016. Epub 2007 Nov 7. Exp Gerontol. 2008. PMID: 18065182
155 results