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Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria.
Di Trani JM, Yu J, Courbon GM, Lobez Rodriguez AP, Cheung CY, Liang Y, Coupland CE, Bueler SA, Cook GM, Brzezinski P, Rubinstein JL. Di Trani JM, et al. Among authors: coupland ce. Proc Natl Acad Sci U S A. 2025 Feb 25;122(8):e2423761122. doi: 10.1073/pnas.2423761122. Epub 2025 Feb 19. Proc Natl Acad Sci U S A. 2025. PMID: 39969994 Free PMC article.
Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Coupland CE, Andrei SA, Ansell TB, Carrique L, Kumar P, Sefer L, Schwab RA, Byrne EFX, Pardon E, Steyaert J, Magee AI, Lanyon-Hogg T, Sansom MSP, Tate EW, Siebold C. Coupland CE, et al. Mol Cell. 2021 Dec 16;81(24):5025-5038.e10. doi: 10.1016/j.molcel.2021.11.018. Epub 2021 Dec 9. Mol Cell. 2021. PMID: 34890564 Free PMC article.
Mapping structural and dynamic divergence across the MBOAT family.
Ansell TB, Healy M, Coupland CE, Sansom MSP, Siebold C. Ansell TB, et al. Among authors: coupland ce. Structure. 2024 Jul 11;32(7):1011-1022.e3. doi: 10.1016/j.str.2024.03.014. Epub 2024 Apr 17. Structure. 2024. PMID: 38636523 Free PMC article.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*.
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Among authors: coupland ce. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13542-13547. doi: 10.1002/anie.202014457. Epub 2021 May 14. Angew Chem Int Ed Engl. 2021. PMID: 33768725 Free PMC article.
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT).
Lanyon-Hogg T, Ritzefeld M, Zhang L, Andrei SA, Pogranyi B, Mondal M, Sefer L, Johnston CD, Coupland CE, Greenfield JL, Newington J, Fuchter MJ, Magee AI, Siebold C, Tate EW. Lanyon-Hogg T, et al. Among authors: coupland ce. Angew Chem Weinheim Bergstr Ger. 2021 Jun 7;133(24):13654-13659. doi: 10.1002/ange.202014457. Epub 2021 May 14. Angew Chem Weinheim Bergstr Ger. 2021. PMID: 38504937 Free PMC article.