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Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease.
Tajes M, Eraso-Pichot A, Rubio-Moscardó F, Guivernau B, Ramos-Fernández E, Bosch-Morató M, Guix FX, Clarimón J, Miscione GP, Boada M, Gil-Gómez G, Suzuki T, Molina H, Villà-Freixa J, Vicente R, Muñoz FJ. Tajes M, et al. Among authors: clarimon j. J Alzheimers Dis. 2014;41(1):273-88. doi: 10.3233/JAD-131685. J Alzheimers Dis. 2014. PMID: 24614897
A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study.
Gómez-Isla T, Blesa R, Boada M, Clarimón J, Del Ser T, Domenech G, Ferro JM, Gómez-Ansón B, Manubens JM, Martínez-Lage JM, Muñoz D, Peña-Casanova J, Torres F; TRIMCI Study Group. Gómez-Isla T, et al. Among authors: clarimon j. Alzheimer Dis Assoc Disord. 2008 Jan-Mar;22(1):21-9. doi: 10.1097/WAD.0b013e3181611024. Alzheimer Dis Assoc Disord. 2008. PMID: 18317243 Clinical Trial.
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, Rodríguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, Hyman BT, Gómez-Isla T. Coma M, et al. Among authors: clarimon j. Neurobiol Dis. 2010 Jun;38(3):482-91. doi: 10.1016/j.nbd.2010.01.019. Epub 2010 Feb 10. Neurobiol Dis. 2010. PMID: 20149872 Free PMC article.
[Genetics of Alzheimer's disease].
Setó-Salvia N, Clarimón J. Setó-Salvia N, et al. Among authors: clarimon j. Rev Neurol. 2010 Mar 16;50(6):360-4. Rev Neurol. 2010. PMID: 20309834 Free article. Spanish.
Activation of PKR causes amyloid ß-peptide accumulation via de-repression of BACE1 expression.
Ill-Raga G, Palomer E, Wozniak MA, Ramos-Fernández E, Bosch-Morató M, Tajes M, Guix FX, Galán JJ, Clarimón J, Antúnez C, Real LM, Boada M, Itzhaki RF, Fandos C, Muñoz FJ. Ill-Raga G, et al. Among authors: clarimon j. PLoS One. 2011;6(6):e21456. doi: 10.1371/journal.pone.0021456. Epub 2011 Jun 28. PLoS One. 2011. PMID: 21738672 Free PMC article.
241 results