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The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis.
Procopiou PA, Browning C, Buckley JM, Clark KL, Fechner L, Gore PM, Hancock AP, Hodgson ST, Holmes DS, Kranz M, Looker BE, Morriss KM, Parton DL, Russell LJ, Slack RJ, Sollis SL, Vile S, Watts CJ. Procopiou PA, et al. Among authors: clark kl. J Med Chem. 2011 Apr 14;54(7):2183-95. doi: 10.1021/jm1013874. Epub 2011 Mar 7. J Med Chem. 2011. PMID: 21381763
Design of Phthalazinone Amide Histamine H1 Receptor Antagonists for Use in Rhinitis.
Procopiou PA, Ford AJ, Gore PM, Looker BE, Hodgson ST, Holmes DS, Vile S, Clark KL, Saunders KA, Slack RJ, Rowedder JE, Watts CJ. Procopiou PA, et al. Among authors: clark kl. ACS Med Chem Lett. 2017 Apr 21;8(5):577-581. doi: 10.1021/acsmedchemlett.7b00112. eCollection 2017 May 11. ACS Med Chem Lett. 2017. PMID: 28523114 Free PMC article.
Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H1 receptor antagonists for use in allergic rhinitis.
Procopiou PA, Ford AJ, Gore PM, Hancock AP, Hodgson ST, Holmes DS, Looker BE, Vile S, Clark KL, Saunders KA, Slack RJ, Watts CJ. Procopiou PA, et al. Among authors: clark kl. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4914-4919. doi: 10.1016/j.bmcl.2017.09.020. Epub 2017 Sep 9. Bioorg Med Chem Lett. 2017. PMID: 28958623
In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization.
Kamola PJ, Kitson JD, Turner G, Maratou K, Eriksson S, Panjwani A, Warnock LC, Douillard Guilloux GA, Moores K, Koppe EL, Wixted WE, Wilson PA, Gooderham NJ, Gant TW, Clark KL, Hughes SA, Edbrooke MR, Parry JD. Kamola PJ, et al. Among authors: clark kl. Nucleic Acids Res. 2015 Oct 15;43(18):8638-50. doi: 10.1093/nar/gkv857. Epub 2015 Sep 3. Nucleic Acids Res. 2015. PMID: 26338776 Free PMC article.
Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs.
Kamola PJ, Maratou K, Wilson PA, Rush K, Mullaney T, McKevitt T, Evans P, Ridings J, Chowdhury P, Roulois A, Fairchild A, McCawley S, Cartwright K, Gooderham NJ, Gant TW, Moores K, Hughes SA, Edbrooke MR, Clark K, Parry JD. Kamola PJ, et al. Mol Ther Nucleic Acids. 2017 Sep 15;8:383-394. doi: 10.1016/j.omtn.2017.07.003. Epub 2017 Jul 8. Mol Ther Nucleic Acids. 2017. PMID: 28918038 Free PMC article.
Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis.
Clark KL, Hughes SA, Bulsara P, Coates J, Moores K, Parry J, Carr M, Mayer RJ, Wilson P, Gruenloh C, Levin D, Darton J, Weber WM, Sobczak K, Gill DR, Hyde SC, Davies LA, Pringle IA, Sumner-Jones SG, Jadhav V, Jamison S, Strapps WR, Pickering V, Edbrooke MR. Clark KL, et al. Mol Ther Nucleic Acids. 2013 Jan 15;2(1):e65. doi: 10.1038/mtna.2012.57. Mol Ther Nucleic Acids. 2013. PMID: 23322014 Free PMC article.
213 results