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Crystal structures of 8-Cl and 9-Cl TIBO complexed with wild-type HIV-1 RT and 8-Cl TIBO complexed with the Tyr181Cys HIV-1 RT drug-resistant mutant.
Das K, Ding J, Hsiou Y, Clark AD Jr, Moereels H, Koymans L, Andries K, Pauwels R, Janssen PA, Boyer PL, Clark P, Smith RH Jr, Kroeger Smith MB, Michejda CJ, Hughes SH, Arnold E. Das K, et al. Among authors: clark p, clark ad jr. J Mol Biol. 1996 Dec 20;264(5):1085-100. doi: 10.1006/jmbi.1996.0698. J Mol Biol. 1996. PMID: 9000632
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.
Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Béthune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E. Das K, et al. Among authors: clark p, clark ad jr. J Med Chem. 2004 May 6;47(10):2550-60. doi: 10.1021/jm030558s. J Med Chem. 2004. PMID: 15115397
Crystals of a ternary complex of human immunodeficiency virus type 1 reverse transcriptase with a monoclonal antibody Fab fragment and double-stranded DNA diffract x-rays to 3.5-A resolution.
Jacobo-Molina A, Clark AD Jr, Williams RL, Nanni RG, Clark P, Ferris AL, Hughes SH, Arnold E. Jacobo-Molina A, et al. Among authors: clark p, clark ad jr. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10895-9. doi: 10.1073/pnas.88.23.10895. Proc Natl Acad Sci U S A. 1991. PMID: 1720554 Free PMC article.
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA.
Jacobo-Molina A, Ding J, Nanni RG, Clark AD Jr, Lu X, Tantillo C, Williams RL, Kamer G, Ferris AL, Clark P, et al. Jacobo-Molina A, et al. Among authors: clark p, clark ad jr. Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6320-4. doi: 10.1073/pnas.90.13.6320. Proc Natl Acad Sci U S A. 1993. PMID: 7687065 Free PMC article.
2,929 results