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Chemical modification study of antisense gapmers.
Stanton R, Sciabola S, Salatto C, Weng Y, Moshinsky D, Little J, Walters E, Kreeger J, DiMattia D, Chen T, Clark T, Liu M, Qian J, Roy M, Dullea R. Stanton R, et al. Among authors: clark t. Nucleic Acid Ther. 2012 Oct;22(5):344-59. doi: 10.1089/nat.2012.0366. Epub 2012 Aug 1. Nucleic Acid Ther. 2012. PMID: 22852836
Study of CRTC2 pharmacology using antisense oligonuceotides.
Dullea R, Salatto C, Sciabola S, Chen T, Dimattia D, Gandhok H, Kreeger J, Weng Y, Clark T, Vage C, Stanton R. Dullea R, et al. Among authors: clark t. Nucleic Acid Ther. 2014 Apr;24(2):127-38. doi: 10.1089/nat.2013.0456. Epub 2013 Dec 31. Nucleic Acid Ther. 2014. PMID: 24380393
Tissue bioanalysis of biotherapeutics and drug targets to support PK/PD.
Neubert H, Fountain S, King L, Clark T, Weng Y, O'Hara DM, Li W, Leung S, Ray C, Palandra J, Ocaña MF, Chen J, Ji C, Wang M, Long K, Gorovits B, Fluhler E. Neubert H, et al. Among authors: clark t. Bioanalysis. 2012 Nov;4(21):2589-604. doi: 10.4155/bio.12.234. Bioanalysis. 2012. PMID: 23173794 Review.
Glyco-engineered Long Acting FGF21 Variant with Optimal Pharmaceutical and Pharmacokinetic Properties to Enable Weekly to Twice Monthly Subcutaneous Dosing.
Weng Y, Ishino T, Sievers A, Talukdar S, Chabot JR, Tam A, Duan W, Kerns K, Sousa E, He T, Logan A, Lee D, Li D, Zhou Y, Bernardo B, Joyce A, Kavosi M, O'Hara DM, Clark T, Guo J, Giragossian C, Stahl M, Calle RA, Kriz R, Somers W, Lin L. Weng Y, et al. Among authors: clark t. Sci Rep. 2018 Mar 9;8(1):4241. doi: 10.1038/s41598-018-22456-w. Sci Rep. 2018. PMID: 29523796 Free PMC article.
PF-06804103, A Site-specific Anti-HER2 Antibody-Drug Conjugate for the Treatment of HER2-expressing Breast, Gastric, and Lung Cancers.
Graziani EI, Sung M, Ma D, Narayanan B, Marquette K, Puthenveetil S, Tumey LN, Bikker J, Casavant J, Bennett EM, Charati MB, Golas J, Hosselet C, Rohde CM, Hu G, Guffroy M, Falahatpisheh H, Finkelstein M, Clark T, Barletta F, Tchistiakova L, Lucas J, Rosfjord E, Loganzo F, O'Donnell CJ, Gerber HP, Sapra P. Graziani EI, et al. Among authors: clark t. Mol Cancer Ther. 2020 Oct;19(10):2068-2078. doi: 10.1158/1535-7163.MCT-20-0237. Epub 2020 Aug 3. Mol Cancer Ther. 2020. PMID: 32747418
A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice.
Fisher TS, Hooper AT, Lucas J, Clark TH, Rohner AK, Peano B, Elliott MW, Tsaparikos K, Wang H, Golas J, Gavriil M, Haddish-Berhane N, Tchistiakova L, Gerber HP, Root AR, May C. Fisher TS, et al. Among authors: clark th. Cancer Immunol Immunother. 2018 Feb;67(2):247-259. doi: 10.1007/s00262-017-2081-0. Epub 2017 Oct 24. Cancer Immunol Immunother. 2018. PMID: 29067496
3,118 results