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238 results
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In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.
Oldham HG, Clarke SE. Oldham HG, et al. Among authors: clarke se. Drug Metab Dispos. 1997 Aug;25(8):970-7. Drug Metab Dispos. 1997. PMID: 9280405
Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).
Baldwin SJ, Bramhall JL, Ashby CA, Yue L, Murdock PR, Hood SR, Ayrton AD, Clarke SE. Baldwin SJ, et al. Among authors: clarke se. Drug Metab Dispos. 2006 Jun;34(6):1063-9. doi: 10.1124/dmd.105.008185. Epub 2006 Mar 10. Drug Metab Dispos. 2006. PMID: 16531474
Quinidine and haloperidol as modifiers of CYP3A4 activity: multisite kinetic model approach.
Galetin A, Clarke SE, Houston JB. Galetin A, et al. Among authors: clarke se. Drug Metab Dispos. 2002 Dec;30(12):1512-22. doi: 10.1124/dmd.30.12.1512. Drug Metab Dispos. 2002. PMID: 12433827
Multisite kinetic analysis of interactions between prototypical CYP3A4 subgroup substrates: midazolam, testosterone, and nifedipine.
Galetin A, Clarke SE, Houston JB. Galetin A, et al. Among authors: clarke se. Drug Metab Dispos. 2003 Sep;31(9):1108-16. doi: 10.1124/dmd.31.9.1108. Drug Metab Dispos. 2003. PMID: 12920166
Multisite kinetic models for CYP3A4: simultaneous activation and inhibition of diazepam and testosterone metabolism.
Kenworthy KE, Clarke SE, Andrews J, Houston JB. Kenworthy KE, et al. Among authors: clarke se. Drug Metab Dispos. 2001 Dec;29(12):1644-51. Drug Metab Dispos. 2001. PMID: 11717184
In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.
Rashidi MR, Smith JA, Clarke SE, Beedham C. Rashidi MR, et al. Among authors: clarke se. Drug Metab Dispos. 1997 Jul;25(7):805-13. Drug Metab Dispos. 1997. PMID: 9224775
In vitro identification of the P450 enzymes responsible for the metabolism of ropinirole.
Bloomer JC, Clarke SE, Chenery RJ. Bloomer JC, et al. Among authors: clarke se. Drug Metab Dispos. 1997 Jul;25(7):840-4. Drug Metab Dispos. 1997. PMID: 9224778
Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone.
Baldwin SJ, Clarke SE, Chenery RJ. Baldwin SJ, et al. Among authors: clarke se. Br J Clin Pharmacol. 1999 Sep;48(3):424-32. doi: 10.1046/j.1365-2125.1999.00030.x. Br J Clin Pharmacol. 1999. PMID: 10510156 Free PMC article.
6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.
Bromidge SM, Duckworth M, Forbes IT, Ham P, King FD, Thewlis KM, Blaney FE, Naylor CB, Blackburn TP, Kennett GA, Wood MD, Clarke SE. Bromidge SM, et al. Among authors: clarke se. J Med Chem. 1997 Oct 24;40(22):3494-6. doi: 10.1021/jm970424c. J Med Chem. 1997. PMID: 9357513 No abstract available.
Rapid screening of taxol metabolites in human microsomes by liquid chromatography/electrospray ionization-mass spectrometry.
Poon GK, Wade J, Bloomer J, Clarke SE, Maltas J. Poon GK, et al. Among authors: clarke se. Rapid Commun Mass Spectrom. 1996;10(10):1165-8. doi: 10.1002/(SICI)1097-0231(19960731)10:10<1165::AID-RCM608>3.0.CO;2-J. Rapid Commun Mass Spectrom. 1996. PMID: 8759326
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