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Effects of syngeneic cellular vaccinations alone or in combination with GM-CSF on the weakly immunogenic F98 glioma model.
Clavreul A, Delhaye M, Jadaud E, Menei P. Clavreul A, et al. J Neurooncol. 2006 Aug;79(1):9-17. doi: 10.1007/s11060-005-9115-8. Epub 2006 Mar 31. J Neurooncol. 2006. PMID: 16575532
This scheme of vaccination induced a systemic cellular and humoral immune response capable of in vitro cytolytic activity against F98 cells. ...Animals vaccinated with GM-CSF or without GM-CSF had respectively a survival time of 26 +/- 2.1 and 25 +/- 4.4 days follow …
This scheme of vaccination induced a systemic cellular and humoral immune response capable of in vitro cytolytic activity against F98 …
[Anti-glioma vaccination].
Delhaye M, Clavreul A, Garcion E, Menei P. Delhaye M, et al. Among authors: clavreul a. Neurochirurgie. 2003 Sep;49(4):459-63. Neurochirurgie. 2003. PMID: 14526258 French. No abstract available.
Development of new polymer-based particulate systems for anti-glioma vaccination.
Sapin A, Garcion E, Clavreul A, Lagarce F, Benoit JP, Menei P. Sapin A, et al. Among authors: clavreul a. Int J Pharm. 2006 Feb 17;309(1-2):1-5. doi: 10.1016/j.ijpharm.2005.10.046. Epub 2005 Dec 28. Int J Pharm. 2006. PMID: 16386390
Biodegradable and biocompatible microspheres represent a promising alternative to conventional adjuvants for anti-tumour vaccination. ...Glioma cell fractions were prepared for adsorption onto poly-D-lysine (PDL)-coated PLGA microspheres formulated using a double-em …
Biodegradable and biocompatible microspheres represent a promising alternative to conventional adjuvants for anti-tumour vaccination. …
Effect of GDNF-releasing biodegradable microspheres on the function and the survival of intrastriatal fetal ventral mesencephalic cell grafts.
Clavreul A, Sindji L, Aubert-Pouëssel A, Benoît JP, Menei P, Montero-Menei CN. Clavreul A, et al. Eur J Pharm Biopharm. 2006 Jun;63(2):221-8. doi: 10.1016/j.ejpb.2005.11.006. Epub 2006 Feb 23. Eur J Pharm Biopharm. 2006. PMID: 16497494
Moreover, the release profile of the GDNF-loaded microspheres showed a sustained release over 56 days of biologically active GDNF at clinically relevant doses. ...Furthermore, the unloaded and the GDNF-loaded microspheres, when they are mixed with FVM cells, may provide …
Moreover, the release profile of the GDNF-loaded microspheres showed a sustained release over 56 days of biologically active GDNF at …
Evaluation of particulate systems supporting tumor cell fractions in a preventive vaccination against intracranial rat glioma.
Sapin A, Clavreul A, Garcion E, Benoit JP, Menei P. Sapin A, et al. Among authors: clavreul a. J Neurosurg. 2006 Nov;105(5):745-52. doi: 10.3171/jns.2006.105.5.745. J Neurosurg. 2006. PMID: 17121138
OBJECT: Irradiated autologous tumor cells are commonly used as a source of antigens in antiglioma vaccinations to activate the immune system. As cell number is often a limiting factor in these cells' preparation, the aim of the present study was to find a mea …
OBJECT: Irradiated autologous tumor cells are commonly used as a source of antigens in antiglioma vaccinations to activate the immune …
Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments.
Béduneau A, Saulnier P, Hindré F, Clavreul A, Leroux JC, Benoit JP. Béduneau A, et al. Among authors: clavreul a. Biomaterials. 2007 Nov;28(33):4978-90. doi: 10.1016/j.biomaterials.2007.05.014. Epub 2007 May 26. Biomaterials. 2007. PMID: 17716725
This coupling was facilitated by the incorporation of lipid PEG(2000) functionalized with reactive-sulfhydryl maleimide groups (DSPE-PEG(2000)-maleimide) into LNC shells by a post-insertion procedure, developed initially for liposome pegylation. ...
This coupling was facilitated by the incorporation of lipid PEG(2000) functionalized with reactive-sulfhydryl maleimide groups (DSPE-PEG(200 …
Human glioma cell culture: two FCS-free media could be recommended for clinical use in immunotherapy.
Clavreul A, Jean I, Preisser L, Chassevent A, Sapin A, Michalak S, Menei P. Clavreul A, et al. In Vitro Cell Dev Biol Anim. 2009 Oct;45(9):500-11. doi: 10.1007/s11626-009-9215-4. Epub 2009 Jun 16. In Vitro Cell Dev Biol Anim. 2009. PMID: 19533255
Immunotherapy, particularly active vaccination, may be developed as an effective and safe treatment modality for malignant gliomas, which continue to have a poor prognosis, despite advances in surgical techniques and adjuvant chemotherapy and radiotherapy. ...In this study …
Immunotherapy, particularly active vaccination, may be developed as an effective and safe treatment modality for malignant gliomas, which co …
Autologous tumor cell vaccination plus infusion of GM-CSF by a programmable pump in the treatment of recurrent malignant gliomas.
Clavreul A, Piard N, Tanguy JY, Gamelin E, Rousselet MC, Leynia P, Menei P. Clavreul A, et al. J Clin Neurosci. 2010 Jul;17(7):842-8. doi: 10.1016/j.jocn.2009.11.017. Epub 2010 May 13. J Clin Neurosci. 2010. PMID: 20466548 Clinical Trial.
We report on the safety and feasibility of autologous tumor cell vaccination combined with infusion of granulocyte-macrophage colony-stimulating factor by a programmable pump in the treatment of recurrent malignant gliomas. The programmable pump is a promising tool …
We report on the safety and feasibility of autologous tumor cell vaccination combined with infusion of granulocyte-macrophage colony-stimula …
Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors.
Roger M, Clavreul A, Venier-Julienne MC, Passirani C, Sindji L, Schiller P, Montero-Menei C, Menei P. Roger M, et al. Among authors: clavreul a. Biomaterials. 2010 Nov;31(32):8393-401. doi: 10.1016/j.biomaterials.2010.07.048. Epub 2010 Aug 5. Biomaterials. 2010. PMID: 20688391
The potential of combinations of drug-loaded nanoparticle systems and adult stem cells for glioma therapy.
Roger M, Clavreul A, Venier-Julienne MC, Passirani C, Montero-Menei C, Menei P. Roger M, et al. Among authors: clavreul a. Biomaterials. 2011 Mar;32(8):2106-16. doi: 10.1016/j.biomaterials.2010.11.056. Epub 2010 Dec 22. Biomaterials. 2011. PMID: 21183214 Review.
Stem cells with a specific tropism for brain tumors could be used as delivery vehicles for nanoparticles. Indeed, these cells have a natural tendency to migrate and distribute within the tumor mass and they can also incorporate nanoparticles. Stem cell therapy combi …
Stem cells with a specific tropism for brain tumors could be used as delivery vehicles for nanoparticles. Indeed, these cells have …
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