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Frailty: we need valid and reliable tools in critical care.
Flaatten H, Clegg A. Flaatten H, et al. Among authors: clegg a. Intensive Care Med. 2018 Nov;44(11):1973-1975. doi: 10.1007/s00134-018-5404-5. Epub 2018 Oct 11. Intensive Care Med. 2018. PMID: 30310928 No abstract available.
Retrospective study of temperature rhythms of intensive care patients.
Tweedie IE, Bell CF, Clegg A, Campbell IT, Minors DS, Waterhouse JM. Tweedie IE, et al. Among authors: clegg a. Crit Care Med. 1989 Nov;17(11):1159-65. doi: 10.1097/00003246-198911000-00012. Crit Care Med. 1989. PMID: 2791594
Using cosinor analysis, a statistically significant rhythm in a period of 24 h was present on 80% of the patient days studied. ...There was a tendency for the amplitude of the rhythm to be greater when the patients were unconscious than when they were conscio …
Using cosinor analysis, a statistically significant rhythm in a period of 24 h was present on 80% of the patient days studied. …
The frailty syndrome.
Clegg A, Young J. Clegg A, et al. Clin Med (Lond). 2011 Feb;11(1):72-5. doi: 10.7861/clinmedicine.11-1-72. Clin Med (Lond). 2011. PMID: 21404792 Free PMC article. Review. No abstract available.
Frailty in elderly people.
Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Clegg A, et al. Lancet. 2013 Mar 2;381(9868):752-62. doi: 10.1016/S0140-6736(12)62167-9. Epub 2013 Feb 8. Lancet. 2013. PMID: 23395245 Free PMC article. Review.
It is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumulative decline in many physiological systems during a lifetime. ...Such progress would greatly inform the appropriate selection of elde …
It is a state of vulnerability to poor resolution of homoeostasis after a stressor event and is a consequence of cumula …
Diagnostic test accuracy of simple instruments for identifying frailty in community-dwelling older people: a systematic review.
Clegg A, Rogers L, Young J. Clegg A, et al. Age Ageing. 2015 Jan;44(1):148-52. doi: 10.1093/ageing/afu157. Epub 2014 Oct 29. Age Ageing. 2015. PMID: 25355618 Review.
BACKGROUND: frailty is a state of vulnerability to adverse outcomes. Routine identification of frailty is recommended in international guidance. ...For a gait speed of <0.8 m/s, the sensitivity = 0.99 and specificity = 0.64. For the PRISMA 7, the sensitivity = 0. …
BACKGROUND: frailty is a state of vulnerability to adverse outcomes. Routine identification of frailty is recommended in internationa …
Managing frailty as a long-term condition.
Harrison JK, Clegg A, Conroy SP, Young J. Harrison JK, et al. Among authors: clegg a. Age Ageing. 2015 Sep;44(5):732-5. doi: 10.1093/ageing/afv085. Epub 2015 Jul 13. Age Ageing. 2015. PMID: 26175349
The recognition of frailty as a long-term condition is not merely a semantic issue-a wide range of benefits can be anticipated. ...A team approach is a key component of long-term condition management, incorporating support, follow-up and behavio …
The recognition of frailty as a long-term condition is not merely a semantic issue-a wide range of benefits can be anti …
Frailty and Organization of Health and Social Care.
Clegg A, Young J. Clegg A, et al. Interdiscip Top Gerontol Geriatr. 2015;41:161-73. doi: 10.1159/000381233. Epub 2015 Jul 17. Interdiscip Top Gerontol Geriatr. 2015. PMID: 26301988 Review.
Development and validation of an electronic frailty index using routine primary care electronic health record data.
Clegg A, Bates C, Young J, Ryan R, Nichols L, Ann Teale E, Mohammed MA, Parry J, Marshall T. Clegg A, et al. Age Ageing. 2016 May;45(3):353-60. doi: 10.1093/ageing/afw039. Epub 2016 Mar 3. Age Ageing. 2016. PMID: 26944937 Free PMC article.
Development and internal validation cohorts were established using a randomly split sample of the ResearchOne primary care database. ...RESULTS: we include data from a total of 931,541 patients. The eFI incorporates 36 deficits constructed using 2,171 CTV3 codes. .. …
Development and internal validation cohorts were established using a randomly split sample of the ResearchOne primary care database. …
Moving upstream in the frailty trajectory.
Todd OM, Clegg AP. Todd OM, et al. Among authors: clegg ap. Age Ageing. 2016 Jul;45(4):438-9. doi: 10.1093/ageing/afw082. Epub 2016 May 4. Age Ageing. 2016. PMID: 27146302 No abstract available.
Frailty and acute coronary syndrome: A structured literature review.
Bebb O, Smith FG, Clegg A, Hall M, Gale CP. Bebb O, et al. Among authors: clegg a. Eur Heart J Acute Cardiovasc Care. 2018 Mar;7(2):166-175. doi: 10.1177/2048872617700873. Epub 2017 Mar 20. Eur Heart J Acute Cardiovasc Care. 2018. PMID: 29064267 Review.
Between 2000 and 2016, we identified only a small number of primary research studies investigating frailty and ACS care ( n = 10). ...Available data for PCI indicated a gap between treatment recommended by international guidelines and clinical practice. Further rese …
Between 2000 and 2016, we identified only a small number of primary research studies investigating frailty and ACS care ( n = 10). .. …
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