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Year Number of Results
1996 2
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130 results

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Page 1
Climbazole causes cell apoptosis and lipidosis in the liver of grass carp.
Lu ZJ, Shi WJ, Gao FZ, Ma DD, Zhang JG, Li SY, Long XB, Zhang QQ, Ying GG. Lu ZJ, et al. Aquat Toxicol. 2023 Oct;263:106698. doi: 10.1016/j.aquatox.2023.106698. Epub 2023 Sep 15. Aquat Toxicol. 2023. PMID: 37722153
Climbazole has showed endocrine-disrupting effects. However, the effects of climbazole in fish are still largely unclear. ...Moreover, climbazole increased transcription and protein levels of apoptosis-related genes. Finally, climbazole damaged mitocho …
Climbazole has showed endocrine-disrupting effects. However, the effects of climbazole in fish are still largely unclear. ...M …
An azole fungicide climbazole damages the gut-brain axis in the grass carp.
Lu ZJ, Shi WJ, Gao FZ, Ma DD, Zhang JG, Li SY, Long XB, Zhang QQ, Ying GG. Lu ZJ, et al. J Hazard Mater. 2024 Mar 5;465:133463. doi: 10.1016/j.jhazmat.2024.133463. Epub 2024 Jan 10. J Hazard Mater. 2024. PMID: 38219582
Azole antifungal climbazole has frequently been detected in aquatic environments and shows various effects in fish. ...Results showed that exposure to 0.2 to 20 mug/L climbazole for 42 days significantly disrupted gut microbiota and caused brain neurotoxicity in gra …
Azole antifungal climbazole has frequently been detected in aquatic environments and shows various effects in fish. ...Results showed …
Rational development of topical climbazole formulations.
Paz-Alvarez M, Fung Tang C, Pudney PD, Lane ME. Paz-Alvarez M, et al. Int J Pharm. 2024 Mar 25;653:123886. doi: 10.1016/j.ijpharm.2024.123886. Epub 2024 Feb 7. Int J Pharm. 2024. PMID: 38331330 Free article.
Previously we reported the characterization of climbazole (CBZ), an antifungal agent used in the management of dandruff. Skin permeation of CBZ from neat solvents was also investigated. ...
Previously we reported the characterization of climbazole (CBZ), an antifungal agent used in the management of dandruff. Skin permeat …
Antifungal climbazole alters androgenic pathways in mammalian cells.
Ndiaye D, Perceau M, Lorcin M, Denis F, Gaté L. Ndiaye D, et al. Toxicol In Vitro. 2024 Aug;99:105854. doi: 10.1016/j.tiv.2024.105854. Epub 2024 May 23. Toxicol In Vitro. 2024. PMID: 38795739
Among antifungal agents used in pharmaceuticals and personal care products, the synthetic azole climbazole (CBZ; 1-(4-Chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutan-2-one) acts on the fungus Malassezia. ...
Among antifungal agents used in pharmaceuticals and personal care products, the synthetic azole climbazole (CBZ; 1-(4-Chlorophenoxy)- …
Climbazole boosts activity of retinoids in skin.
Adamus J, Feng L, Hawkins S, Kalleberg K, Lee JM. Adamus J, et al. Int J Cosmet Sci. 2017 Aug;39(4):411-418. doi: 10.1111/ics.12390. Epub 2017 Mar 2. Int J Cosmet Sci. 2017. PMID: 28103388 Clinical Trial.
OBJECTIVE: To explore whether climbazole enhances retinoid-associated biological activities in vitro and in vivo. METHODS: Primary human dermal fibroblasts (HDFs) were treated from six to 48 h with either retinoids (retinol, retinyl propionate, retinyl palmitate) alone or …
OBJECTIVE: To explore whether climbazole enhances retinoid-associated biological activities in vitro and in vivo. METHODS: Primary hu …
The azole biocide climbazole induces oxidative stress, inflammation, and apoptosis in fish gut.
Lu ZJ, Shi WJ, Ma DD, Zhang JG, Long XB, Li SY, Gao FZ, Zhang QQ, Ying GG. Lu ZJ, et al. Sci Total Environ. 2024 May 1;923:171475. doi: 10.1016/j.scitotenv.2024.171475. Epub 2024 Mar 6. Sci Total Environ. 2024. PMID: 38453063
Climbazole is an azole biocide that has been widely used in formulations of personal care products. Climbazole can cause developmental toxicity and endocrine disruption as well as gut disturbance in aquatic organisms. ...
Climbazole is an azole biocide that has been widely used in formulations of personal care products. Climbazole can cause devel …
Long-term exposure to climbazole may affect the health of stress-tolerant coral Galaxea fascicularis.
Sun C, Huang Y, Bakhtiari AR, Yuan D, Zhou Y, Zhao H. Sun C, et al. Mar Environ Res. 2024 Oct;201:106679. doi: 10.1016/j.marenvres.2024.106679. Epub 2024 Aug 10. Mar Environ Res. 2024. PMID: 39153271
However, the effects of climbazole on coral remain largely unknown. Therefore, in this study, we conducted a 42-day investigation to examine the effects of varying concentrations of climbazole on Galaxea fascicularis (G. fascicularis), a stress-tolerant coral specie …
However, the effects of climbazole on coral remain largely unknown. Therefore, in this study, we conducted a 42-day investigation to …
Climbazole increases expression of cornified envelope proteins in primary keratinocytes.
Pople JE, Moore AE, Talbot DC, Barrett KE, Jones DA, Lim FL. Pople JE, et al. Int J Cosmet Sci. 2014 Oct;36(5):419-26. doi: 10.1111/ics.12137. Epub 2014 Jul 25. Int J Cosmet Sci. 2014. PMID: 24811958
The objective of this study was to evaluate the anti-dandruff ingredient climbazole for potential skin benefits using genomics and in vitro assays. METHODS: Microarray analysis was performed to profile gene expression changes in climbazole-treated primary human kera …
The objective of this study was to evaluate the anti-dandruff ingredient climbazole for potential skin benefits using genomics and in …
Characterization of Climbazole-Bovine serum albumin interaction by experimental and in silico approaches.
Zahirul Kabir M, Tayyab H, Erkmen C, Kurbanoglu S, Mohamad SB, Uslu B. Zahirul Kabir M, et al. Spectrochim Acta A Mol Biomol Spectrosc. 2023 Mar 5;288:122197. doi: 10.1016/j.saa.2022.122197. Epub 2022 Nov 29. Spectrochim Acta A Mol Biomol Spectrosc. 2023. PMID: 36470090
Interactive association of an antifungal drug, climbazole (CBZ) with the carrier protein in bovine circulation, bovine serum albumin (BSA) was explored by fluorescence and absorption spectroscopy along with in silico techniques. ...
Interactive association of an antifungal drug, climbazole (CBZ) with the carrier protein in bovine circulation, bovine serum albumin …
Percutaneous absorption of climbazole: In vitro data from human skin.
Champmartin C, Aubertin M, Seiwert C, Cosnier F. Champmartin C, et al. Regul Toxicol Pharmacol. 2025 Nov;162:105895. doi: 10.1016/j.yrtph.2025.105895. Epub 2025 Jun 24. Regul Toxicol Pharmacol. 2025. PMID: 40571243 Free article.
Climbazole is an antifungal substance used as an active ingredient or antimicrobial preservative in pharmaceuticals and personal care products. ...These new percutaneous absorption data will enhance the assessment of the occupational risks associated with dermal exposure t …
Climbazole is an antifungal substance used as an active ingredient or antimicrobial preservative in pharmaceuticals and personal care …
130 results