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Year Number of Results
1994 1
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1998 5
1999 4
2000 2
2001 4
2002 4
2003 3
2005 2
2006 5
2007 1
2008 5
2009 5
2010 3
2011 2
2012 4
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2014 3
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2016 6
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2019 2
2020 3
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91 results

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Page 1
Imaging Structural and Functional Dynamics in Xenopus Neurons.
Cline HT. Cline HT. Cold Spring Harb Protoc. 2022 Feb 1;2022(2):pdb.top106773. doi: 10.1101/pdb.top106773. Cold Spring Harb Protoc. 2022. PMID: 34531329 Free PMC article.
Because of its many advantages as an experimental system, use of Xenopus has often been at the forefront of developing these imaging methods for in vivo applications. Protocols for in vivo structural and functional imaging-including cellular labeling strategies, image coll …
Because of its many advantages as an experimental system, use of Xenopus has often been at the forefront of developing these imaging …
Morpholino Studies in Xenopus Brain Development.
Bestman JE, Cline HT. Bestman JE, et al. Among authors: cline ht. Methods Mol Biol. 2020;2047:377-395. doi: 10.1007/978-1-4939-9732-9_21. Methods Mol Biol. 2020. PMID: 31552666
MOs are widely used to alter gene expression in development of Xenopus and Zebrafish, where they are typically injected into the fertilized egg or blastomeres. Here we present methods to use electroporation to target delivery of MOs to the central nervous system of Xeno …
MOs are widely used to alter gene expression in development of Xenopus and Zebrafish, where they are typically injected into the fert …
Application of Recombinant Rabies Virus to Xenopus Tadpole Brain.
Faulkner RL, Wall NR, Callaway EM, Cline HT. Faulkner RL, et al. Among authors: cline ht. eNeuro. 2021 Jun 7;8(4):ENEURO.0477-20.2021. doi: 10.1523/ENEURO.0477-20.2021. Online ahead of print. eNeuro. 2021. PMID: 34099488 Free PMC article.
The Xenopus laevis experimental system has provided significant insight into the development and plasticity of neural circuits. ...Here, we show that recombinant rabies virus transduces neurons in the Xenopus tadpole, enlarging the toolbox that can be applied …
The Xenopus laevis experimental system has provided significant insight into the development and plasticity of neural circuits …
Temporal and spatial transcriptomic dynamics across brain development in Xenopus laevis tadpoles.
Ta AC, Huang LC, McKeown CR, Bestman JE, Van Keuren-Jensen K, Cline HT. Ta AC, et al. Among authors: cline ht. G3 (Bethesda). 2022 Jan 4;12(1):jkab387. doi: 10.1093/g3journal/jkab387. G3 (Bethesda). 2022. PMID: 34751375 Free PMC article.
We conducted differential gene expression analyses of the developing Xenopus laevis tadpole brain during this period in two ways: first, over stages of the development in the midbrain and, second, across regions of the brain at a single developmental stage. ...
We conducted differential gene expression analyses of the developing Xenopus laevis tadpole brain during this period in two wa …
Electrophysiological Recording for Study of Xenopus Retinotectal Circuitry.
Luo Y, Shen W, Cline HT. Luo Y, et al. Among authors: cline ht. Cold Spring Harb Protoc. 2021 Jun 1;2021(6):10.1101/pdb.prot106880. doi: 10.1101/pdb.prot106880. Cold Spring Harb Protoc. 2021. PMID: 33785560 Free PMC article.
The innervation of the optic tectum of Xenopus by retinal ganglion cells controls visual information processing and behavioral output. ...The protocol described here provides instructions for performing in vivo electrophysiological recordings from individual tectal neurons …
The innervation of the optic tectum of Xenopus by retinal ganglion cells controls visual information processing and behavioral output …
Experience-dependent plasticity of excitatory and inhibitory intertectal inputs in Xenopus tadpoles.
Gambrill AC, Faulkner R, Cline HT. Gambrill AC, et al. Among authors: cline ht. J Neurophysiol. 2016 Nov;116(5):2281-2297. doi: 10.1152/jn.00611.2016. Epub 2016 Aug 31. J Neurophysiol. 2016. PMID: 27582296 Free PMC article.
We combined neuronal tracing, in vivo time-lapse imaging, and electrophysiology to characterize the structural and functional development of intertectal axons and synapses in Xenopus tadpole optic tectum. We find that intertectal connections are established early during op …
We combined neuronal tracing, in vivo time-lapse imaging, and electrophysiology to characterize the structural and functional development of …
Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis.
Gore SV, James EJ, Huang LC, Park JJ, Berghella A, Thompson AC, Cline HT, Aizenman CD. Gore SV, et al. Among authors: cline ht. Elife. 2021 Jul 20;10:e62147. doi: 10.7554/eLife.62147. Elife. 2021. PMID: 34282726 Free PMC article.
Here, we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperconnectivity observed in Xenopus tadpoles after early exposure to valproic acid (VPA), a known teratogen associated with ND in humans. …
Here, we test the hypothesis that chronically elevated MMP-9 activity during early neurodevelopment is responsible for neural circuit hyperc …
In Vivo Time-Lapse Imaging and Analysis of Dendritic Structural Plasticity in Xenopus laevis Tadpoles.
He HY, Lin CY, Cline HT. He HY, et al. Among authors: cline ht. Cold Spring Harb Protoc. 2022 Jan 4;2022(1):pdb.prot106781. doi: 10.1101/pdb.prot106781. Cold Spring Harb Protoc. 2022. PMID: 33790043 Free PMC article.
In vivo time-lapse imaging of complete dendritic arbor structures in tectal neurons of Xenopus laevis tadpoles has served as a powerful in vivo model to study activity-dependent structural plasticity in the central nervous system during early development. ...
In vivo time-lapse imaging of complete dendritic arbor structures in tectal neurons of Xenopus laevis tadpoles has served as a …
Enhanced visual experience rehabilitates the injured brain in Xenopus tadpoles in an NMDAR-dependent manner.
Gambrill AC, Faulkner RL, McKeown CR, Cline HT. Gambrill AC, et al. Among authors: cline ht. J Neurophysiol. 2019 Jan 1;121(1):306-320. doi: 10.1152/jn.00664.2018. Epub 2018 Dec 5. J Neurophysiol. 2019. PMID: 30517041 Free PMC article.
Traumatic brain injuries introduce functional and structural circuit deficits that must be repaired for an organism to regain function. We developed an injury model in which Xenopus laevis tadpoles are given a penetrating stab wound that damages the optic tectal cir …
Traumatic brain injuries introduce functional and structural circuit deficits that must be repaired for an organism to regain function. We d …
91 results