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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1932 2
1945 1
1946 8
1947 9
1948 13
1949 12
1950 12
1951 13
1952 8
1953 23
1954 20
1955 36
1956 52
1957 36
1958 54
1959 62
1960 69
1961 60
1962 101
1963 131
1964 191
1965 1271
1966 1617
1967 1734
1968 1982
1969 2152
1970 2285
1971 2289
1972 2645
1973 2985
1974 3324
1975 3965
1976 4253
1977 4237
1978 4650
1979 4607
1980 4662
1981 5219
1982 5719
1983 6510
1984 6669
1985 7471
1986 8286
1987 8806
1988 9325
1989 11242
1990 12690
1991 13586
1992 13882
1993 15211
1994 22739
1995 24831
1996 24206
1997 26309
1998 27585
1999 30192
2000 29797
2001 30461
2002 32557
2003 36996
2004 40464
2005 43380
2006 43310
2007 43913
2008 44880
2009 46703
2010 49255
2011 53686
2012 56931
2013 60678
2014 60028
2015 59248
2016 58028
2017 57777
2018 58698
2019 61548
2020 63789
2021 64060
2022 58125
2023 54021
2024 57591
2025 3320

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1,450,003 results

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Page 1
An introduction to clinical trial design.
Schultz A, Saville BR, Marsh JA, Snelling TL. Schultz A, et al. Paediatr Respir Rev. 2019 Nov;32:30-35. doi: 10.1016/j.prrv.2019.06.002. Epub 2019 Jun 26. Paediatr Respir Rev. 2019. PMID: 31427159 Review.
A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generalizability of the results. This manuscript will give a brief overview of clinical trial design including the strengths and limitat …
A good working knowledge of clinical trial design is essential to expertly interpret and determine the validity and generaliza …
Clinical Trial Considerations in Neuro-oncology.
Lee EQ. Lee EQ. Curr Treat Options Oncol. 2021 Jul 2;22(9):78. doi: 10.1007/s11864-021-00875-8. Curr Treat Options Oncol. 2021. PMID: 34213625 Free PMC article. Review.
Efforts to increase the efficiency and interpretability of clinical trials within the neuro-oncology community have focused on standardization of response assessment, development of consensus guidelines for clinical trial conduct, decentralization of clinical trials …
Efforts to increase the efficiency and interpretability of clinical trials within the neuro-oncology community have focused on standardizati …
Key concepts of clinical trials: a narrative review.
Umscheid CA, Margolis DJ, Grossman CE. Umscheid CA, et al. Postgrad Med. 2011 Sep;123(5):194-204. doi: 10.3810/pgm.2011.09.2475. Postgrad Med. 2011. PMID: 21904102 Free PMC article. Review.
However, clinical trials also have the potential to pose unknown risks to their participants, and biased knowledge extracted from flawed clinical trials may lead to the inadvertent harm of patients. Although conducting a well-designed clinical trial may appear strai …
However, clinical trials also have the potential to pose unknown risks to their participants, and biased knowledge extracted from flawed cli …
SPIRIT 2013 statement: defining standard protocol items for clinical trials.
Chan AW, Tetzlaff JM, Altman DG, Laupacis A, Gøtzsche PC, Krleža-Jerić K, Hróbjartsson A, Mann H, Dickersin K, Berlin JA, Doré CJ, Parulekar WR, Summerskill WS, Groves T, Schulz KF, Sox HC, Rockhold FW, Rennie D, Moher D. Chan AW, et al. Ann Intern Med. 2013 Feb 5;158(3):200-7. doi: 10.7326/0003-4819-158-3-201302050-00583. Ann Intern Med. 2013. PMID: 23295957 Free PMC article.
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, and appraisal. ...This article describes the systematic development and scope of SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2013, a gui …
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, and appraisal. ...This artic …
Organizing a clinical trial for the new investigator.
Kukreja JB, Thompson IM Jr, Chapin BF. Kukreja JB, et al. Urol Oncol. 2019 May;37(5):336-339. doi: 10.1016/j.urolonc.2017.12.017. Epub 2018 Feb 1. Urol Oncol. 2019. PMID: 29395953 Free PMC article. Review.
BACKGROUND AND PURPOSE: Clinical trials organization can be daunting especially when orienting to a new system. The steps to a successful clinical trial are not concrete and vary based on the system. METHODS: In this section the discussion centers on how to shape th …
BACKGROUND AND PURPOSE: Clinical trials organization can be daunting especially when orienting to a new system. The steps to a successful …
Preparation of an Academic Clinical Trial.
Ramalhinho AC, Castelo-Branco M. Ramalhinho AC, et al. Methods Mol Biol. 2021;2197:317-330. doi: 10.1007/978-1-0716-0872-2_18. Methods Mol Biol. 2021. PMID: 32827146 Review.
This chapter will describe the most important steps when planning a clinical trial with DNA vaccines, such as regulatory and submission requirements, designing of a successful clinical trial protocol, stakeholders' responsibilities, and feasibility ass …
This chapter will describe the most important steps when planning a clinical trial with DNA vaccines, such as regulatory and s …
Innovation in oncology clinical trial design.
Verweij J, Hendriks HR, Zwierzina H; Cancer Drug Development Forum. Verweij J, et al. Cancer Treat Rev. 2019 Mar;74:15-20. doi: 10.1016/j.ctrv.2019.01.001. Epub 2019 Jan 4. Cancer Treat Rev. 2019. PMID: 30665053 Review.
Progress in and better understanding of cancer biology causes a shift in cancer drug development: away from the evaluation of drugs in large tumour histology defined patient populations towards targeted agents in increasingly heterogeneous molecularly defined subpopulations. This …
Progress in and better understanding of cancer biology causes a shift in cancer drug development: away from the evaluation of drugs in large …
Neurofibromatosis Clinical Trial Consortium.
Packer RJ, Fisher MJ, Cutter G, Cole-Plourde K, Korf BR. Packer RJ, et al. J Child Neurol. 2018 Jan;33(1):82-91. doi: 10.1177/0883073817739196. J Child Neurol. 2018. PMID: 29246097 Review.
The rapid unravelling of the genetic underpinnings of these unique disorders has led to the development of novel therapies, especially molecular-targeted therapies. To facilitate clinical trial development, the Neurofibromatosis Clinical Trial Consorti …
The rapid unravelling of the genetic underpinnings of these unique disorders has led to the development of novel therapies, especially molec …
Clinical trial enrollment among adolescents with cancer: supplement overview.
Tai E, Beaupin L, Bleyer A. Tai E, et al. Pediatrics. 2014 Jun;133 Suppl 3(Suppl 3):S85-90. doi: 10.1542/peds.2014-0122B. Pediatrics. 2014. PMID: 24918212 Free PMC article. Review.
However, adolescents with cancer aged 15 to 19 years have had less progress in survival prolongation compared with younger children, which may be due to lower clinical trial enrollment among adolescents with cancer. To help address this issue, the Centers for Diseas …
However, adolescents with cancer aged 15 to 19 years have had less progress in survival prolongation compared with younger children, which m …
Trial watch: Trends in clinical trial design complexity.
Getz KA, Campo RA. Getz KA, et al. Nat Rev Drug Discov. 2017 May;16(5):307. doi: 10.1038/nrd.2017.65. Epub 2017 Apr 18. Nat Rev Drug Discov. 2017. PMID: 28417986 Review. No abstract available.
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