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TBLR1 fuses to retinoid acid receptor alpha in a variant t(3;17)(q26;q21) translocation of acute promyelocytic leukemia.
Chen Y, Li S, Zhou C, Li C, Ru K, Rao Q, Xing H, Tian Z, Tang K, Mi Y, Wang B, Wang M, Wang J. Chen Y, et al. Blood. 2014 Aug 7;124(6):936-45. doi: 10.1182/blood-2013-10-528596. Epub 2014 Apr 29. Blood. 2014. PMID: 24782508 Free article.
The majority of acute promyelocytic leukemia (APL) cases are characterized by the PML-RARalpha fusion gene. Although the PML-RARalpha fusion gene can be detected in >98% of APL cases, RARalpha is also found to be fused with othe …
The majority of acute promyelocytic leukemia (APL) cases are characterized by the PML-RARalpha fusion gene
Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).
Licht JD, Chomienne C, Goy A, Chen A, Scott AA, Head DR, Michaux JL, Wu Y, DeBlasio A, Miller WH Jr, et al. Licht JD, et al. Blood. 1995 Feb 15;85(4):1083-94. Blood. 1995. PMID: 7849296 Free article.
Analysis of a variant translocation t(11;17) in a case of acute promyelocytic leukemia (APL) led to discovery of a novel zinc finger gene, PLZF, fused to the retinoic acid receptor-alpha (RAR alpha) gene. We reviewed the …
Analysis of a variant translocation t(11;17) in a case of acute promyelocytic leukemia (APL) led to discovery of …
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.
Ablain J, Rice K, Soilihi H, de Reynies A, Minucci S, de Thé H. Ablain J, et al. Nat Med. 2014 Feb;20(2):167-74. doi: 10.1038/nm.3441. Epub 2014 Jan 12. Nat Med. 2014. PMID: 24412926
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid receptor-alpha (PML-RARA) fusion protein, which interferes with nuclear receptor signaling and PML nuclear body (NB
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)-retinoic acid
BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia.
Yamamoto Y, Tsuzuki S, Tsuzuki M, Handa K, Inaguma Y, Emi N. Yamamoto Y, et al. Blood. 2010 Nov 18;116(20):4274-83. doi: 10.1182/blood-2010-01-264432. Epub 2010 Aug 31. Blood. 2010. PMID: 20807888 Free article.
The majority of acute promyelocytic leukemia (APL) cases are characterized by the presence of a promyelocytic leukemia-retinoic acid receptor alpha(RARA) fusion gene. ...Although the patient was clinically resp …
The majority of acute promyelocytic leukemia (APL) cases are characterized by the presence of a promyelocytic
A new variant translocation in acute promyelocytic leukaemia: molecular characterization and clinical correlation.
Wells RA, Hummel JL, De Koven A, Zipursky A, Kirby M, Dubé I, Kamel-Reid S. Wells RA, et al. Leukemia. 1996 Apr;10(4):735-40. Leukemia. 1996. PMID: 8618456
We describe a patient with APL in whom the leukaemic clone was characterized by a true variant of the classical t(15;17). The patient whose disease had numerous atypical clinical features, had t(11;17)(q13;121). The chromosome 17 breakpoint was localized to i …
We describe a patient with APL in whom the leukaemic clone was characterized by a true variant of the classical t(15;17). The patient …
HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3.
Scott AA, Head DR, Kopecky KJ, Appelbaum FR, Theil KS, Grever MR, Chen IM, Whittaker MH, Griffith BB, Licht JD, et al. Scott AA, et al. Blood. 1994 Jul 1;84(1):244-55. Blood. 1994. PMID: 7517211 Free article.
We have identified and characterized a previously unrecognized form of acute leukemia that shares features of both myeloid and natural killer (NK) cells. ...However, all 20 cases lacked the t(15;17) and 17 cases tested lacked the promyelocytic/retinoic …
We have identified and characterized a previously unrecognized form of acute leukemia that shares features of both myel …