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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C19 and Voriconazole Therapy.
Moriyama B, Obeng AO, Barbarino J, Penzak SR, Henning SA, Scott SA, Agúndez J, Wingard JR, McLeod HL, Klein TE, Cross SJ, Caudle KE, Walsh TJ. Moriyama B, et al. Clin Pharmacol Ther. 2017 Jul;102(1):45-51. doi: 10.1002/cpt.583. Epub 2017 Apr 18. Clin Pharmacol Ther. 2017. PMID: 27981572 Free PMC article.
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant CYP2C19 alleles. ...We summarize evidence from the literature supporting this association and provide therapeutic recommendations fo
Voriconazole, a triazole antifungal agent, demonstrates wide interpatient variability in serum concentrations, due in part to variant
Voriconazole Therapy and CYP2C19 Genotype.
Dean L. Dean L. 2019 Dec 27. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. 2019 Dec 27. In: Pratt VM, Scott SA, Pirmohamed M, Esquivel B, Kattman BL, Malheiro AJ, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012–. PMID: 31886997 Free Books & Documents. Review.
Genetic tests are currently available for the voriconazole response and the CYP2C19 gene. The FDA-approved drug label for voriconazole discusses the influence of CYP2C19 on drug levels but does not provide specific dosing recommendations based on the …
Genetic tests are currently available for the voriconazole response and the CYP2C19 gene. The FDA-approved drug label for v