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A highly sensitive method for the simultaneous UHPLC-MS/MS analysis of clonidine, morphine, midazolam and their metabolites in blood plasma using HFIP as the eluent additive.
Veigure R, Aro R, Metsvaht T, Standing JF, Lutsar I, Herodes K, Kipper K; CloSed Consortium. Veigure R, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 May 1;1052:150-157. doi: 10.1016/j.jchromb.2017.03.007. Epub 2017 Mar 10. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28388512 Free article.
The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial.
Neubert A, Baarslag MA, Dijk MV, Rosmalen JV, Standing JF, Sheng Y, Rascher W, Roberts D, Winslade J, Rawcliffe L, Hanning SM, Metsvaht T, Giannuzzi V, Larsson P, Pokorná P, Simonetti A, Tibboel D; CLOSED Consortium. Neubert A, et al. BMJ Open. 2017 Jun 21;7(6):e016031. doi: 10.1136/bmjopen-2017-016031. BMJ Open. 2017. PMID: 28637741 Free PMC article. Clinical Trial.