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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1962 1
1963 49
1964 14
1965 10
1967 2
1968 5
1969 17
1970 65
1971 143
1972 162
1973 166
1974 166
1975 185
1976 178
1977 176
1978 186
1979 194
1980 198
1981 150
1982 145
1983 109
1984 105
1985 106
1986 105
1987 76
1988 91
1989 88
1990 94
1991 98
1992 97
1993 101
1994 97
1995 90
1996 115
1997 66
1998 93
1999 77
2000 73
2001 68
2002 65
2003 85
2004 83
2005 135
2006 126
2007 133
2008 124
2009 118
2010 74
2011 38
2012 54
2013 35
2014 34
2015 35
2016 36
2017 37
2018 30
2019 22
2020 30
2021 16
2022 16
2023 13

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5,163 results

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Page 1
Additive effects of clofibric acid and pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) deficiency on hepatic steatosis in mice fed a high saturated fat diet.
Hwang B, Wu P, Harris RA. Hwang B, et al. FEBS J. 2012 May;279(10):1883-93. doi: 10.1111/j.1742-4658.2012.08569.x. Epub 2012 Apr 4. FEBS J. 2012. PMID: 22429297 Free PMC article.
Surprisingly, rather than decreasing the effectiveness of clofibric acid, PDK4 deficiency enhanced the beneficial effects of clofibric acid on hepatic steatosis, reduced blood glucose levels, and did not prevent the positive effects of clofibric …
Surprisingly, rather than decreasing the effectiveness of clofibric acid, PDK4 deficiency enhanced the beneficial effects of …
Clofibric acid increases the formation of oleic acid in endoplasmic reticulum of the liver of rats.
Hirose A, Yamazaki T, Sakamoto T, Sunaga K, Tsuda T, Mitsumoto A, Kudo N, Kawashima Y. Hirose A, et al. J Pharmacol Sci. 2011;116(4):362-72. doi: 10.1254/jphs.11020fp. Epub 2011 Jul 14. J Pharmacol Sci. 2011. PMID: 21757842 Free article.
The effects of 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) on the formation of oleic acid (18:1) from stearic acid (18:0) and utilization of the 18:1 formed for phosphatidylcholine (PC) formation in endoplasmic reticulum in the l …
The effects of 2-(4-chlorophenoxy)-2-methylpropionic acid (clofibric acid) on the formation of oleic acid (18:1) …
Clofibric acid and gemfibrozil removal in membrane bioreactors.
Gutierrez-Macias T, Nacheva PM. Gutierrez-Macias T, et al. Water Sci Technol. 2015;71(8):1143-50. doi: 10.2166/wst.2015.079. Water Sci Technol. 2015. PMID: 25909723
The removal of two blood lipid regulators, clofibric acid (CLA) and gemfibrozil (GFZ), was evaluated using two identical aerobic membrane bioreactors with 6.5 L effective volume each. ...
The removal of two blood lipid regulators, clofibric acid (CLA) and gemfibrozil (GFZ), was evaluated using two identical aerob …
Biodegradation of clofibric acid and identification of its metabolites.
Salgado R, Oehmen A, Carvalho G, Noronha JP, Reis MA. Salgado R, et al. J Hazard Mater. 2012 Nov 30;241-242:182-9. doi: 10.1016/j.jhazmat.2012.09.029. Epub 2012 Sep 24. J Hazard Mater. 2012. PMID: 23062606
Clofibric acid (CLF) is the pharmaceutically active metabolite of lipid regulators clofibrate, etofibrate and etofyllinclofibrate, and it is considered both environmentally persistent and refractory. ...Three main metabolites were identified, including alpha-hydroxy …
Clofibric acid (CLF) is the pharmaceutically active metabolite of lipid regulators clofibrate, etofibrate and etofyllinclofibr …
A renal mechanism for the clofibric acid-probenecid interaction.
Meffin PJ, Zilm DM, Veenendaal JR. Meffin PJ, et al. J Pharmacol Exp Ther. 1983 Dec;227(3):739-42. J Pharmacol Exp Ther. 1983. PMID: 6655567
Rabbits administered probenecid (10 mg/kg followed by 10 mg/kg/hr) showed a mean reduction from control values of 68% for clofibric acid plasma clearance, 80% for clofibric acid glucuronide renal clearance and an elevation in the area under the plasma …
Rabbits administered probenecid (10 mg/kg followed by 10 mg/kg/hr) showed a mean reduction from control values of 68% for clofibric …
Clofibric acid, phenylpyruvate, and dichloroacetate inhibition of branched-chain alpha-ketoacid dehydrogenase kinase in vitro and in perfused rat heart.
Paxton R, Harris RA. Paxton R, et al. Arch Biochem Biophys. 1984 May 15;231(1):58-66. doi: 10.1016/0003-9861(84)90362-x. Arch Biochem Biophys. 1984. PMID: 6721502
Branched-chain alpha-ketoacid dehydrogenase kinase, purified from rabbit liver, was inhibited by clofibric acid, phenylpyruvate, and dichloroacetate in a mixed manner relative to ATP. ...These findings suggest that, although clofibric acid and phenylpy …
Branched-chain alpha-ketoacid dehydrogenase kinase, purified from rabbit liver, was inhibited by clofibric acid, phenylpyruvat …
Diisopropylfluorophosphate increases clofibric acid clearance: supporting evidence for a futile cycle.
Rowe BJ, Meffin PJ. Rowe BJ, et al. J Pharmacol Exp Ther. 1984 Jul;230(1):237-41. J Pharmacol Exp Ther. 1984. PMID: 6747828
If hydrolysis is mediated by esterases then inhibition of these enzymes should increase clofibric acid clearance. Plasma clofibric acid clearance was measured in a group of six rabbits both while conscious and then while anesthetized and treated with d …
If hydrolysis is mediated by esterases then inhibition of these enzymes should increase clofibric acid clearance. Plasma cl …
Clofibric acid degradation in UV254/H2O2 process: effect of temperature.
Li W, Lu S, Qiu Z, Lin K. Li W, et al. J Hazard Mater. 2010 Apr 15;176(1-3):1051-7. doi: 10.1016/j.jhazmat.2009.11.147. Epub 2009 Dec 3. J Hazard Mater. 2010. PMID: 20042284
The degradation of clofibric acid (CA) in UV(254)/H(2)O(2) process under three temperature ranges, i.e. ...The effects of solution constituents including NO(3)(-) and HCO(3)(-) anions, and humic acid (HA) on CA degradation were evaluated in Milli-Q waters. CA …
The degradation of clofibric acid (CA) in UV(254)/H(2)O(2) process under three temperature ranges, i.e. ...The effects of solu …
Reduced clofibric acid clearance in renal dysfunction is due to a futile cycle.
Meffin PJ, Zilm DM, Veenendaal JR. Meffin PJ, et al. J Pharmacol Exp Ther. 1983 Dec;227(3):732-8. J Pharmacol Exp Ther. 1983. PMID: 6655566
Fifty percent of administered clofibric acid glucuronide is hydrolyzed to clofibric acid in rabbits with normal renal function. These studies support a mechanism for the renal function dependent plasma clearance of clofibric acid involvin …
Fifty percent of administered clofibric acid glucuronide is hydrolyzed to clofibric acid in rabbits with normal …
Clofibrate and clofibric acid: comparison of the metabolic disposition in rats and dogs.
Cayen MN, Ferdinandi ES, Greselin E, Robinson WT, Dvornik D. Cayen MN, et al. J Pharmacol Exp Ther. 1977 Jan;200(1):33-43. J Pharmacol Exp Ther. 1977. PMID: 833760
In rats, equimolar oral doses of [14C]clofibrate and [14c]clofibric acid produced essentially the same profiles of blood levels, tissue distribution and excretion of radioactivity. ...The data are in accordance with the view that the pharmacological activity of clof …
In rats, equimolar oral doses of [14C]clofibrate and [14c]clofibric acid produced essentially the same profiles of blood level …
5,163 results